ID A0A137PAK8_CONC2 Unreviewed; 600 AA.
AC A0A137PAK8;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=DNA mismatch repair protein MutL {ECO:0000313|EMBL:KXN72050.1};
DE Flags: Fragment;
GN ORFNames=CONCODRAFT_5179 {ECO:0000313|EMBL:KXN72050.1};
OS Conidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638)
OS (Delacroixia coronata).
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC Entomophthoromycotina; Entomophthoromycetes; Entomophthorales;
OC Ancylistaceae; Conidiobolus.
OX NCBI_TaxID=796925 {ECO:0000313|EMBL:KXN72050.1, ECO:0000313|Proteomes:UP000070444};
RN [1] {ECO:0000313|EMBL:KXN72050.1, ECO:0000313|Proteomes:UP000070444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 28638 {ECO:0000313|EMBL:KXN72050.1,
RC ECO:0000313|Proteomes:UP000070444};
RX PubMed=25977457; DOI=10.1093/gbe/evv090;
RA Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA Spatafora J.W., Berbee M.L.;
RT "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT Walls of Algal Ancestors of Land Plants.";
RL Genome Biol. Evol. 7:1590-1601(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KQ964461; KXN72050.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A137PAK8; -.
DR STRING; 796925.A0A137PAK8; -.
DR EnsemblFungi; KXN72050; KXN72050; CONCODRAFT_5179.
DR OMA; ANYHVKK; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000070444; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000070444}.
FT DOMAIN 223..348
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 349..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 600
FT /evidence="ECO:0000313|EMBL:KXN72050.1"
SQ SEQUENCE 600 AA; 67944 MW; 47EDF1935DF6EFCC CRC64;
MSQLASIKKL DDVVVNRIAA GEVIQTPAHA IKELVENCLD AKANRVEVIC NSGGLKSIIV
SDNGTGIQYD DLPLLCQRFT TSKIANYEDL NQLNTRGFRG EALASISYVS HVKVKTRTEV
NDTAFEAAYE MGELVPLKAG LSKDPVPCAG NKGTTITVED IFYNSPMRRP SIGSAKDCYQ
KIVSILKPFA LHHYKNLSLT VKRSNNTVPD LHTTSSQNQI DKIAQIYGAV IVKHLLPLEG
TNGEELEMGQ GYKLKGYATK LSYASKSMQM VCFINDRYVE WERLKRAIKF LYATLLPKNT
TYPFIYLSFT MDPNLVEVNV HPTKKEVIVM DEEDVIKWTV EAIQSQLQSS TTTSLNSNPL
PSPVISLKNS TSHEGGDRDT FESHSTPRKS VKPYNLIHTD PQTRHIQTTP SKHLPPQPKE
PSLDSTDLQP NQLTSIKELS QEFINHIDPD LIYMISNHTW VGNLQYPHSS ALIQCDTQLC
MVNYTYLSER IVYWLCLQYF GQFQIIEIKP PVPIKEFFNR YVQKLPDADK QKIHPLLSQG
LVDQLNQIKD MLKEYFSIII DDEGQLIGIP EILPNYIPKI THFPKLFFDF ASRVNWDDEK
//
