ID   A0A137Q2D0_9AGAR        Unreviewed;       944 AA.
AC   A0A137Q2D0;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Metacaspase-1 {ECO:0000313|EMBL:KXN81402.1};
GN   ORFNames=AN958_04759 {ECO:0000313|EMBL:KXN81402.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN81402.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN81402.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN81402.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family.
CC       {ECO:0000256|ARBA:ARBA00009005}.
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DR   EMBL; KQ963360; KXN81402.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A137Q2D0; -.
DR   OrthoDB; 1077459at2759; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.12660; -; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR   PANTHER; PTHR48104; METACASPASE-4; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW   Protease {ECO:0000256|ARBA:ARBA00022807};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          214..498
FT                   /note="Peptidase C14 caspase"
FT                   /evidence="ECO:0000259|Pfam:PF00656"
FT   REGION          1..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..56
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..87
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..115
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        853..871
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  101731 MW;  ED36DCA719EA6773 CRC64;
     MSFFKEVKDT YKHAQQQGYR STDAPAFPQA PGALGGYPPP SGPPPSGPPP SGPPASSGYN
     PSYAPSYGPP AGGYPPPSGP PSQQGFGFPT PSPGFNTPSY PPPSGPPPSS RYPQSSPQPP
     SSGGYPGQQY NLQRSSHQGG YLGQQHHQQQ HHQQHYPPPS NPPPGGYQPG GNQWHPQGPP
     PRPPNTVQNY GPQFQGPNHQ PAQPFFQYSQ CTGKKKALCI GINYVGQNGE LRGCINDARN
     IQRFLCSRFG YKTEDIVMLT DDAQNPRMKP TKDNIIQAMQ WLVKGAAPND SLFFHYSGHG
     GQTKDVDGDE ADGYDEVIYP LDFQQKGHIV DDLMHEIMVK PLPTGCRLTA IFDSCHSGSA
     LDLPYIYSTE GKVKEPNLAA EAGQGLLSAV SSYAKGDMGG VFKSALGLVK TAAGNSSKAD
     KYAKATRTSS ADVISWSGCK DSQTSADTQE AGQATGAMSY AFTSALSSNT QQSYQELLNN
     IRDILRSKYD QKPQLSSSHP MIAMSTFSLL SGVPVLVGEK NWVEWSESME NILLMTTLPG
     LIYTAWDIAD SIIAIPQLVV DQPAVQAQAA TAMTPAVPAQ AATFTVASIE AQNNWRSLDR
     MAHSMINNRL SGHLLHHNQT STPLLWTHLM TLFGTRSAAT IFADYQVTVS FHINSNVEPS
     SQLALLENAY SHLERSVPPI RIPEFVRAMN LLNAIPREWS YVMTTYLQTH PLANINYASV
     RSAILTQWQH QHQVRAHEAN MSRAGMRSDG SDKKKKPRKR GKGSKGQQAN SADAELVSPA
     VAAAAPDNTY VASSAFAVAS PAIISNPKIS GLSTRQKVND ARASRAAESA VPPRPLAERL
     STPVGDAPSS PRPAAVSLPP PQSPLNVLPP PTSAPDADMI SLGDDASDYG DDNYVPNYGL
     DDGTVQGQAA EVERLRSLGL SQEPPYQCCP FGRHVEFDTL MDRM
//