ID A0A137Q5S7_9AGAR Unreviewed; 1418 AA.
AC A0A137Q5S7;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Dicer-like protein 1 {ECO:0000313|EMBL:KXN82617.1};
GN ORFNames=AN958_02468 {ECO:0000313|EMBL:KXN82617.1};
OS Leucoagaricus sp. SymC.cos.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN82617.1, ECO:0000313|Proteomes:UP000070249};
RN [1] {ECO:0000313|EMBL:KXN82617.1, ECO:0000313|Proteomes:UP000070249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SymC.cos {ECO:0000313|EMBL:KXN82617.1,
RC ECO:0000313|Proteomes:UP000070249};
RA Hu H.;
RT "Leucoagaricus sp. SymC.cos WGS genome.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; KQ962949; KXN82617.1; -; Genomic_DNA.
DR STRING; 1714833.A0A137Q5S7; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000070249; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 23..198
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 362..539
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 564..654
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 934..1077
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1116..1263
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 514..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..541
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 159054 MW; 4B33FA1517087046 CRC64;
MTISDSETNT THDLRPRKYQ EEIFERAQKE NVIAALNTGS GKTLIGLLLI KWISALESAR
DKLIIFLVPR VTLVDQQANY ISENTPLRVS KLSGALDIEL SDRMRWRRRL EHCDVLVMTP
QILVNMITHS LWGLQRVALL VFDECHHTRK NHPYNIIMRE YFQIKAQKER PKVFGMTASP
IWNMKDPVGS LLTLEKNMDS IIIGVREHTQ ELAVHTPRPS ELINIYSMPP KEYDFHEPTL
FHCLSTISPS TWDYIKIPWS NLVVRYDTTL YNLGPYCASL YLFLEVWHAV KRVQPELSVT
NGLEMEDAGV TSTKNSRKVF PKEVAIIRDI LAGYEGFFWV ASSPNIVPTG VPTGWCSPKV
IALRDILLEF YTANFQAIVF VEQRQTAACL SKVLPAIPEL KGKIRSAHLV GQGANIDGVS
KTTDAYHGDA VNAFRAGKVN VLLATSVAEE GLNFPACDLV VRFDPLRHMV AYVQSRGRAR
NAASRFVVMI RENDLEALTL YQTLQAHEPE MNRAYQSRHG EADTTPDLQE ADEDEDDELD
PSDLAGRERY IVPKTNAPLT YDNAIELLNR LCSLIPCDAY TPSHKPKFIE GFQSTVKLPL
SIPLPPEQLI YTGPLKHSKK EAKRAVAFMA AKHLHELNVF DDYLLPTPGK GLTKEESAHA
LLDLQPQVTP VMIDVEVKYP WTLGDRLWLH PVYVKGEPSM GLIAGVLLPL VELHSDALLR
LGRPQILQLD VEDEMEKRRA MHEYTRLGIF YRVTGSPLAN ALGAFLVPLT DDLEVDFDQI
LRVVENPKGI FNWEGVEGGR DTFLVLNKPE HGRTRVLRQT RDDLSPMSTP PDGSVEAVYP
TYHEYWSVKW ARGNKRFEVP TDGPLLEAPR LVKHAISNYS LDPSHRIPPV QPDLQVSPIV
PLHSCGWVNM SPEIIRVFEL FPMLCHKLTD AYRAQAIRSY IGLPLIPDDL LIEALTLPSV
DADFSNQRLE TLGDAVLDIC TTVHMMIKYP RRHEGQLSNL RQRVISNKFL VSCARVVGLE
IFISSERTSV SKWPFVEQDG YEDKAFRERK SVKRQIPRRG LQDCVEALLG ASFIAGGIPV
ALQTGVALGL SFGGLQPWGE RVKRNERKSL GVPALVVKLQ KELGYTFENA ELLVEAVTHP
SFESSTTPSY QRLEFLGDSV IKMVVTIYLF NKFPNATSHQ LALPRTKSIC SPALASLGIR
KLQVHKYILH NSVDLNHAIN LYIPILESTS AEEIVRRGWR YDPPKAISDV FESIVGAIFV
DTGYNLDRTS GIVTWLMEDV LEALSPSTPK DPVSELLEWL GSVGCSGHMK FDKTTGQKDG
VAVEGVSAVF HGTVVSGPIV SASKNVAKFA AAEKALVALR NVNKGELLKK LCDCKHRMVV
DEAKKDIESD QRSEDGEDAE EEKEEAEVAQ MLTGEEFS
//
