ID   A0A137QD14_9AGAR        Unreviewed;       528 AA.
AC   A0A137QD14;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|PIRNR:PIRNR039099};
GN   ORFNames=AN958_11693 {ECO:0000313|EMBL:KXN85116.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN85116.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN85116.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN85116.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
CC       {ECO:0000256|PIRNR:PIRNR039099}.
CC   -!- PATHWAY: Protein modification; protein neddylation.
CC       {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC       ECO:0000256|PIRNR:PIRNR039099}.
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DR   EMBL; KQ962514; KXN85116.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A137QD14; -.
DR   STRING; 1714833.A0A137QD14; -.
DR   OrthoDB; 5488891at2759; -.
DR   UniPathway; UPA00885; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR030667; APP-BP1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PIRSF; PIRSF039099; APP-BP1; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW   Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
SQ   SEQUENCE   528 AA;  57791 MW;  B3679E47423F1A71 CRC64;
     MSQDTKDIEQ VTTAIATEAP PDSKTRRYDR QLRLWAATGQ AALESAHLLV LSSTATSTSI
     LKNLVLPGVG AFTILDDTVV TSADAGNNFF LEGPLSIGRP RAQEAVRLLG ELNEGVRGNA
     DIRNVEQLLA AGKSELFKYT LVIAHNLPRS QLERLSQLLW EDEDAPPLVV VRSAGFLAEF
     FIQQHEHTVI ESHSETTPSL RIDKPFPALL RYAQSLDLNA LDPTDHGHVP YVILLVKAMG
     KWKQEHNGSP PQSSAERNAF KELIRSMKRK IDEENFEEAE AQAYRSWTET IVPREVKELF
     NDSKLQTLSA SSPPFFHLLA ALKRFAAQPP YTLPLTSTLP DMKASTDAYI GLQRLYKDQV
     EREKGVFKSF ISPEVHISDD LIDSFVKNAH ALKVIRGTSW DSIDKDANAL GNAAAVSPKQ
     LAIHLALSAA SSLASSAPAT PEGELPVFTV EALRQEAQSL LSPGTELPEE FEHTGGELAR
     SPTADLPNTA ALLGGLVAQE VIKMITKQYI PIAGICTVDL IETWTGIL
//