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Database: UniProt
Entry: A0A137QRX9_9AGAR
LinkDB: A0A137QRX9_9AGAR
Original site: A0A137QRX9_9AGAR 
ID   A0A137QRX9_9AGAR        Unreviewed;      1564 AA.
AC   A0A137QRX9;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   05-JUN-2019, entry version 17.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=AN958_05022 {ECO:0000313|EMBL:KXN90017.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Agaricaceae;
OC   Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN90017.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN90017.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN90017.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KQ962072; KXN90017.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 2.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070249};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       41    178       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      704    876       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      943   1389       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1449   1521       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      260    283       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A137QRX9}.
FT   REGION      395    448       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A137QRX9}.
FT   REGION     1544   1564       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A137QRX9}.
FT   COMPBIAS    396    428       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A137QRX9}.
SQ   SEQUENCE   1564 AA;  176942 MW;  5F238EE5EB4AB99A CRC64;
     MLAVQIHQID YILNSSGPLD LSQHPRIPVL RIYGQSSVGL RTCIHVHQVY PYCYIDYPGK
     LHPRHVKRYI ANLKQSLNHA IALSLKRDPT SKSHYVRAIF LVKGVKFYGF HSRYSPFLKV
     VLLDPRLTSR VAAILQSGSV LSNRFQVYES HLSFILQFLC DFGLYGCGSI EFSKAYRRMG
     SEEEEEPADL DTKVTFEPSP YSRQTRMPLE LDITGPLILN RVQLVERKLH HSLALPGPER
     PTEPLVISVR ELWEDERNRR RARGLDPTPE IPNDPSEFSR KPNNGWVSEA HWWDELRGRL
     EREQTLKESD MTNDVSKWEN QVMSVFESTE ALWEAQYRTW KPSGEKGDGD AEANIAQDIN
     GLALSMFEDS GEAGEVDVNE AILAAEATDY HFDAAGEPES DEDESDESDD EVGEEKEGAE
     EVDENHSEEI VETSENGETH VDKPRLPVIL GPSDQECSKV RFLPEIFITH SQLLITSIIV
     KMKEVKRMGK LGSESYFNFG LPVRKLIHFC ENSRSEFTLV LGPDSRAPAS SPTMHSTLAT
     VQTSFQPIKI LQRRMSSGRN CFAYSRAPPG KLELSGILHN IETQIYRTPF YSDEADISEN
     PREFAGLVYH LKGGKGIAPL DTFATTSKVP SAQGSQSEIR FEQYSGWEYA ASPPSKRSVR
     RWIQQDKKTG ARSLRQKVLR SQIEGPTQFN VYGFKSSPLE HAVKSSRDKQ NMTIMCLEVF
     APAPEKSVPD PETDSICVAV YGLQLAGTEE IHTGIIAIQN VQLNPKRIRD FYLDIVDTEL
     DLINRISDIV GEFDPDILIG WEVQRASWGY LNFRARQYEF DLQDFLSRAP AQRTGGDDRW
     GSQTASSLKV AGRHVLNAWR IMRSEQALTS YSLSSVAFHV LQQRIPFYST ATLSTWYDSP
     VPSHMVSLLR YLITYVVVTL RILEEAEIVT KTAEFARIFG VDFYSVISRG SQFKVESFMF
     RIAKPENFVL LSPSKNDVGR QNAAECMPLI MEPMSAFYSS PLVVLDFQSL YPSVMIAYNY
     CYSTCLGRVT PFQGQYKFGV TKLDLPPLIL KTLKEHITIA PNGIMYAKRY IRKGLLGRML
     IELLDTRVMV KQSMKAVKSD KTLTRILNAR QLALKYIANV TYGYTSATYS GRMPAVEIAD
     SIVQTGRETL EKAIDMINEN EKWGAKVVYG DTDSLFIYLP GKTREQAFRI GTEIADTVTS
     QNPAPVKLKF EKVYHPCVLM AKKRYVGFKY ENPDEQEPVF DAKGIETVRR DGVLAQRKLV
     ENCLKILFRT QDLSQVKDYC CRSWYKMLEN KVPIHDFIFA KEVRLGTYSS RGPPPPGVVV
     AARKMIIDPN NEPQYGERVP YVVIRGEPGT LLTERAMDPL DMINESHLQL DANYYITRVL
     IPPLERIFNL VGADVRQWFA EMPKGKNATR QTLLASPSKR KKLAIEDEEL PGSPGKQWDI
     EEHLENNQCL VCGEPAFAAS IDICYECFLS GQSSMSVLGA KSCGFDRRML TVHNVCASCA
     ATAPGEPVKC ISLDCPWLYA RKRAEDRMEL VETIDIIVEE LGQDRSRRPS TSSEEMSESK
     TADI
//
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