ID A0A137QTL3_9AGAR Unreviewed; 202 AA.
AC A0A137QTL3;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=EKC/KEOPS complex subunit CGI121 {ECO:0000256|ARBA:ARBA00016009};
DE AltName: Full=EKC/KEOPS complex subunit cgi121 {ECO:0000256|ARBA:ARBA00015316};
GN ORFNames=AN958_04227 {ECO:0000313|EMBL:KXN90555.1};
OS Leucoagaricus sp. SymC.cos.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN90555.1, ECO:0000313|Proteomes:UP000070249};
RN [1] {ECO:0000313|EMBL:KXN90555.1, ECO:0000313|Proteomes:UP000070249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SymC.cos {ECO:0000313|EMBL:KXN90555.1,
RC ECO:0000313|Proteomes:UP000070249};
RA Hu H.;
RT "Leucoagaricus sp. SymC.cos WGS genome.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as
CC an allosteric effector that regulates the t(6)A activity of the
CC complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC and telomere elongation. The complex is required for efficient
CC recruitment of transcriptional coactivators. CGI121 is not required for
CC tRNA modification. {ECO:0000256|ARBA:ARBA00025043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CGI121/TPRKB family.
CC {ECO:0000256|ARBA:ARBA00005546, ECO:0000256|RuleBase:RU004398}.
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DR EMBL; KQ962046; KXN90555.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A137QTL3; -.
DR STRING; 1714833.A0A137QTL3; -.
DR OrthoDB; 1437975at2759; -.
DR Proteomes; UP000070249; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2380.10; CGI121/TPRKB; 1.
DR InterPro; IPR013926; CGI121/TPRKB.
DR InterPro; IPR036504; CGI121/TPRKB_sf.
DR PANTHER; PTHR15840; CGI-121 FAMILY MEMBER; 1.
DR PANTHER; PTHR15840:SF10; EKC_KEOPS COMPLEX SUBUNIT TPRKB; 1.
DR Pfam; PF08617; CGI-121; 1.
DR SUPFAM; SSF143870; PF0523-like; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004398};
KW Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
SQ SEQUENCE 202 AA; 22348 MW; 46226F28B78DFD30 CRC64;
MDLFYFPHLT PDRAATHVAL FRNVKNAASL RKRIISAATM EGEAGELERE EVNFAFIDAR
LITSRLHLQT AVYQSILAEA QEGLRTKTVH SEVLWNLNPT NNITEAIRRY GVSDTTASLF
VVRIDAGTLS GGEMELRMKK VVDGDLVPLS QLREVTDWST IKKYHKLANE PSLKAAGGDL
AVEFSVIDNI VTSTVAMKSV MA
//