GenomeNet

Database: UniProt
Entry: A0A137QY55_9AGAR
LinkDB: A0A137QY55_9AGAR
Original site: A0A137QY55_9AGAR 
ID   A0A137QY55_9AGAR        Unreviewed;       372 AA.
AC   A0A137QY55;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   16-JAN-2019, entry version 8.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR036497};
DE            Short=HDH {ECO:0000256|PIRNR:PIRNR036497};
DE            EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR036497};
GN   ORFNames=AN958_09228 {ECO:0000313|EMBL:KXN92136.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Agaricaceae;
OC   Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN92136.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN92136.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN92136.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036497};
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036497}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KQ961922; KXN92136.1; -; Genomic_DNA.
DR   OrthoDB; 998704at2759; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|PIRNR:PIRNR036497};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070249};
KW   Isoleucine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Methionine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   NADP {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|PIRSR:PIRSR036497-2};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036497};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW   Threonine biosynthesis {ECO:0000256|PIRNR:PIRNR036497}.
FT   DOMAIN       14    146       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      156    369       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      14     19       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    228    228       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      97     97       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     121    121       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     213    213       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   372 AA;  39354 MW;  A9C3A80A7853E478 CRC64;
     MSAAQSKIHV AIVGVGLVGS ELINQILAIP QQSSPFSLIS LSSSTRTLFD KSNPIQPGAD
     WKSALAASSS KADLGALAQQ LKELVVENKR VAIVDNTSSD QVAALYPEWL RYGFNVITPN
     KKAFSGELSL FGDILKASKE SGARFLNEAT VGAGLPIVNT LKELVTSGDK VIQIEGVFSG
     TMSYIFNEFS TGKPDGPNFS SVVAVAREKG YTEPHPADDL NGFDVARKLT ILSRTISSFS
     STPTSLPQLQ SFKSVETASL IPPALEGIPT GDEFISRLPE FDAEFAKLRT KANAEGKVLR
     FVGVVDAANG QVKAGLEKYP ITHPFATSLG GSDNIILFHT ERYSPRPLIV QGAGAGAAVT
     AMGVLGDLLK LA
//
DBGET integrated database retrieval system