ID A0A138ADX0_9ACTN Unreviewed; 384 AA.
AC A0A138ADX0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein {ECO:0000313|EMBL:KXP08691.1};
GN ORFNames=AXK60_08435 {ECO:0000313|EMBL:KXP08691.1};
OS Tsukamurella pseudospumae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=239498 {ECO:0000313|EMBL:KXP08691.1, ECO:0000313|Proteomes:UP000070258};
RN [1] {ECO:0000313|Proteomes:UP000070258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15929 {ECO:0000313|Proteomes:UP000070258};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXP08691.1}.
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DR EMBL; LSRF01000044; KXP08691.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A138ADX0; -.
DR STRING; 239498.AXK60_08435; -.
DR Proteomes; UP000070258; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091}.
FT DOMAIN 290..381
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 290..381
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 384 AA; 40173 MW; C26B0A4995080570 CRC64;
MTTAWKDGSP MTEAPQRPLL GFTVAVTAAR RADELTTLLE RRGAAVIAAP AIAMVPLSDD
ERLRAATEEL LENTPDLLVA TTGIGFRGWL EAAEGWGVAE RLLAALGTGR VISRGPKATG
ALRAAGLREE WSPPSESSAE VLSHLSGTDL TGRRVAVQLH GATDEWDPNP GLLEGLRALG
AEIVPVPVYR WEQPDDLTGL DRVVEAIATG AVDAVTFTSA PAAASVLERA AELGLGAALR
GALTGAVVPY CVGPVTATPL DRAGIASVTP ERMRLGALAR LVEQDLPERR PDLAVAGHAL
GIRARGAVVD GVDRELTPTS IVLLRLLSRE PGAVVSRDDL LAALGGDDPH AVEAAVARLR
AGLGHKEIVA TVVKRGYRLA VEER
//
