ID A0A138AUJ6_9ACTN Unreviewed; 403 AA.
AC A0A138AUJ6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KXP14118.1};
GN ORFNames=AXK60_21775 {ECO:0000313|EMBL:KXP14118.1};
OS Tsukamurella pseudospumae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=239498 {ECO:0000313|EMBL:KXP14118.1, ECO:0000313|Proteomes:UP000070258};
RN [1] {ECO:0000313|Proteomes:UP000070258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15929 {ECO:0000313|Proteomes:UP000070258};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXP14118.1}.
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DR EMBL; LSRF01000007; KXP14118.1; -; Genomic_DNA.
DR RefSeq; WP_068570199.1; NZ_LSRF01000007.1.
DR AlphaFoldDB; A0A138AUJ6; -.
DR STRING; 239498.AXK60_21775; -.
DR Proteomes; UP000070258; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 5..230
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 281..402
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 359
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 389
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 403 AA; 41943 MW; B8C91B2796FD6BFC CRC64;
MPEAFIYEAI RTPRGKQRGG ALHATKPLDL VVGLIDELKD RYPTMDPSAI DDIVLGVVSP
VGEQGGDIAR TAATVAGLPE TVAGVQINRF CASGLEATNM AAQKVAAGLG DDLVLAGGVE
SMSRVPLGSD GGAMHQDVTT NYDTYFVPQG IGADLIASID GYTREDVDTY AAQSQANAAA
AWDNGWFAKS VVPVKDINGL TVLDNDEHRR PGTTAESLAK LKPAFDGIGA MGGFDAVALQ
KYYTVEKINH VHTGGNSSGI VDGAALLLIG NEAGGKKAGL TPRGRIVATA VTGSEPTIML
TGPTPATEKV LAKAGLSKEQ IDHWELNEAF ASVVLRWMKD MKLEREQVNP LGGAIALGHP
LGATGAMLVS TVLDNLERSG GRYGLITLCV GGGMGIATII ERL
//
