ID   A0A139A022_GONPJ        Unreviewed;       994 AA.
AC   A0A139A022;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=M427DRAFT_74614 {ECO:0000313|EMBL:KXS10074.1};
OS   Gonapodya prolifera (strain JEL478) (Monoblepharis prolifera).
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Monoblepharidomycetes; Monoblepharidales;
OC   Gonapodyaceae; Gonapodya.
OX   NCBI_TaxID=1344416 {ECO:0000313|EMBL:KXS10074.1, ECO:0000313|Proteomes:UP000070544};
RN   [1] {ECO:0000313|EMBL:KXS10074.1, ECO:0000313|Proteomes:UP000070544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEL478 {ECO:0000313|EMBL:KXS10074.1,
RC   ECO:0000313|Proteomes:UP000070544};
RX   PubMed=25977457; DOI=10.1093/gbe/evv090;
RA   Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA   Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA   Spatafora J.W., Berbee M.L.;
RT   "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT   Walls of Algal Ancestors of Land Plants.";
RL   Genome Biol. Evol. 7:1590-1601(2015).
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; KQ965838; KXS10074.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A139A022; -.
DR   STRING; 1344416.A0A139A022; -.
DR   OMA; FSFMPEF; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000070544; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070544};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          2..238
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          582..947
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   994 AA;  109005 MW;  C7F2F1CF4FDAC169 CRC64;
     MSCVLSEINP SRITSSSASV LLNFYLERLH DQPSVGELAK GLLALLKSDR LTKTEASAIA
     SRIFEEINLQ TYQQSVRNNI YRIIELLMQK CGEQLQEDAA NFLPAYIQAM DGEKDPRNLV
     IAFGLVRDIL RVFDIGDNAE DVCNVLFAYF PITFKPPPDD PYGITTEDLR DGLRNCLVAS
     PLIADFAIPA LLEKLASSNP TAKRDAMDVL ALGTLTYPPI AFKPHIQTIW ELAKEDIMKA
     QDNSEEQRQV LSFLRSIAKG FSTNTWSSTS KGEEALSLFL TEALEECLQH LKEPESKLAR
     ISGKILTTLI EASDPCCHQV VGVAAPSLFQ LLQGELSSTG RNAVVEDLVD FVSGGRILYG
     SRAEVSNRED VDADSSPFLQ HKDLLLDIFS VTAQTPNETG IRITGLRGMV ALALSRDLLA
     EAELRNVIIQ LQRFLVDDSE ELVSDAALQA VADVCRHVPT LIMQNTIPLL FSEARDLSLT
     PDRFARTMES IEVIAIETET SANVVLAELL SLFFERVKAL SGNESLDDVA MTSLLAILGT
     IQGILQTRME HVLNPSYAQT RASAAENDKD PGLAVAEALL EATITAAIAR DPSTANQALS
     DVEIVNNVAE IISTAIRISD VQHSTEFVRR IFATFFGNKL SEFVKNSVQD SQMLRFEPLK
     RNATESAARV VPILLSAVTA ITPATQLPLS SPSDFLYSLS AEAIASPSPR HGACLSKIAA
     VILNKWDRGG QLSHRVENDI CPELETYLDG DGPLVVPALV AYAWLARALV LKSSKLGMKM
     ASKLISVLGN NATSKLGIEA LETLLSDSED VISKQNAAVI KPLYKQKLFT TLLPIINEGI
     RTASSERIRH NYLVVLSKLI KSAPNHIIIP ELAQLLPTLF TSLTYPDEVL QGSVIDIFHL
     LLAEAASMLT PHISSLIPVL LDLANHRRNP RSMNVRSQSL DCLQAMPASI RYDILHPHVK
     RVLAQLDSCL DDPKKSVRRV AVACKGRWLF LTKD
//