ID A0A139AAU4_GONPJ Unreviewed; 4528 AA.
AC A0A139AAU4;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=M427DRAFT_500117 {ECO:0000313|EMBL:KXS13794.1};
OS Gonapodya prolifera (strain JEL478) (Monoblepharis prolifera).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Monoblepharidomycetes; Monoblepharidales;
OC Gonapodyaceae; Gonapodya.
OX NCBI_TaxID=1344416 {ECO:0000313|EMBL:KXS13794.1, ECO:0000313|Proteomes:UP000070544};
RN [1] {ECO:0000313|EMBL:KXS13794.1, ECO:0000313|Proteomes:UP000070544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL478 {ECO:0000313|EMBL:KXS13794.1,
RC ECO:0000313|Proteomes:UP000070544};
RX PubMed=25977457; DOI=10.1093/gbe/evv090;
RA Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA Spatafora J.W., Berbee M.L.;
RT "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT Walls of Algal Ancestors of Land Plants.";
RL Genome Biol. Evol. 7:1590-1601(2015).
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DR EMBL; KQ965775; KXS13794.1; -; Genomic_DNA.
DR STRING; 1344416.A0A139AAU4; -.
DR OMA; FQKRDRY; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000070544; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070544}.
FT DOMAIN 1877..2014
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2157..2284
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2486..2634
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3630..3668
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4528 AA; 515192 MW; 2334875725D94A30 CRC64;
MDTRGALGSQ NLRRSSMSLN PLPDASGESR KKPSVNNATL DKKRASLDAR HRYMLEKFAA
IVDEKAATLE NHLLYSNKLE TLNEFLSENG PRKILFFWQP PSKDEAILVK GLQYNKNVLL
VTHGSKEGLT GVGAFFLRFS NKAITVANVH MEMACGPLAA GILPSLTTCV KNVIIPALRS
QENWGILQRS KDESVKSFLE ALERFVNDLD VAMVNLQDSV QLHACMVDLD AYKKPSEYAN
AAYTPEVVTG LETLVSEWCK QIEQVLAESE QMRKEADDIG PNAELAHWKA RMVKFNSITD
QLKSLTCRKV IGVLNAVKSK AHLKTWRDLD NRVTDAANES KDNVKYLYTL ERFCEPLYQA
DPLSMIPTIP GLINAIKMIY SISRYYNTSE RMTSLFVKIT NQMITSCKEY IYKDGGTNLW
DQERVQLVKK LNDCVRLNEA YQRCFHETKH KLQETPNEKQ FDFSEMYIFG KFDAFCKRIQ
KVIDMFNIIE KFSLLEKLGV EGMDSINKRF MTILMGMQRK PYDILDHRKI EYDTDYNNFK
RQISDLEGTL QQFIDASFER ISSTEQALLL LSKFGQIRDM ALDLEAKYHT VFVHYTRRDL
EGVRKLYQKC RDSPPIPRNT PPVSGAISWA RQLYRRIEIP MKFFKDKTTV LESVEAKKHI
KNYNKLARAL IEFEMLWYNS WFSVVEQTKT GLQATLLVSD PEGNLFVNFD PAITQLIKEI
RCMYRLGLEV PDSVREVALK EATYKELLTG LEMILQTKER LIKKILPVLR KAIAPHIEQV
DRTLQPGLTA LTWTSLNLNS YLSANNIQLQ KLEELVDKLL DIAQYRIENG LHKIFELSLC
DTPLEAEQWT VEQFLERTEK RCTSIIQTIN NRSNLIEAAT RDLIAELSKG VPHPLTTDMR
IGHENVYYHF NLQNFEALIQ CIKGSFDLLK SRLGNYSSNQ YSKTTTQKPF FRAELVLLIP
NVVLQPKLED IQAALNKATS MLMDVPKRLQ LNWATYLTLA DDPPTGRGPE DMSQIATNKD
ILKLTLMLSS TVNSMKKDVE IHREQFSKFD FLWRDDKADT ITKFLGNNPT INDFESEINR
YEGIEREISE IASTVQIGLL SISSEPLKLA LIGETKNWKQ QFGLNLNRKV KKDMEELIEY
MDSKTVRLSR KIADIEDLRL AVATLSEIRE TEVDIDMKVQ PIEEAYLLLM KHNVTVSKEE
TEKVDSLRYS WKKLKSLVVD VQENLNKIQP VFKQELVTSV EKFTQDVKDF TVEYTDNGPM
VANLPPKTAI ERLNVFQRAF DELNRKWEMY SAGEELFSLP VTPFPALVRI KKELKLLQNL
YSLYNDVLEK KNGYNETLWS DIKIDQMNND MADFQNKIKK LPKGVKEWDA FLELKKTVDN
MTEMVPLLEL MTNKAMQQRH WTRIMDLTKT VFNLDPDNFY LRHVMEAPLV QNREDVEDIC
VSAVKEADIE IKLRGVVSSW EDKVFILGAF KNRGNLILKP ATTSEIIALC EDSLMTLGSL
LTNRYNVPFK PEIQTWVHNL STASEVIEQW LGVQNLWIYL EAVFVGGDIA KQMPKEAKRF
SNIDKSWCKI MGSANEHPNV IQCCVADETI PNLLPHLTEQ LELCQKSLSG YLESKRAIFP
RFYFVSDPSL LEILGQASDS HTIQAHLRNV FDNVNGVQFH EKEYDKIVGL ESAEGERVML
SKPMQAVGNV EVWLGTLLTS MQASVNDIIR ESVSRMHEMA LIKFLDEYPA QIGLLGLQIL
WTQMTEEALN ASKSDKKKMT STLQRVTDIL NSLIEVTTKD LSKMDRTKYE TFITIQVHHR
DVSDKLVKTH IKAADDFEWL KQARFYWHET KDCCIASITN FDFRYQCEYL GCTDRLVITP
LTDRCYITLA QAMGMSLGGS PAGPAGTGKT ETTKDMGKAL GKWVVVFNCS DQMDYRGLGR
IYKGLAQSGC WGCFDEFNRI ELPVLSVAAQ QIGCILAARK ERKKTFVFTD GETVELNPEV
GMFITMNPGY AGRVELPENL KVHFRYVAMM VPDRQIIIRV KLAGAGFINN IVLAKKFFVL
YRLCEEQLSK QVHYDFGLRN ILSVLRTSGS VKRGNPEDSE MVIMMRVLRD MNVSKLVDED
EALFMSLVND LFPGLTAKKG SYPQVEAAID QQLQEAGLIS YPQWTLKIIQ LYETCKVRHG
IMVLGPPGVG KTRCIHSLLK ALTACGDVHK EIRMNPKAIT DYQMFGRLDV ATNDWTDGIF
SAIWRKTLKK KGEFIWMTLD GPVDTIWIES LNSVLDDNKC LTLANGDRIN MSPTCKLMFE
VHSLKNASPA TVSRCGMIYV GVTALPWEVI LQGWFKTRPA NEVAILEPLF SSIFGTASQF
VNIDLHAKMT VPESTYVQTA TMFLAGMIPK SDAPAKSSIA ADHLERLFIF AVFWTLGSLL
ELDERKKLQT FLVEKAPHLK FPPIDNSSQD TIFEYFVDDS GDWAHWRDRV PTWEYPNDHD
PEYSSIIIPM VDNVRMEFLM DLVTKQGKAV LLIGEPGTAK TVTALKFLSR LNPETQLFKK
LNFSSATTPM IFQRTVESYL DKRMGSTYGP PAGKKMTLFI DDINMPEIND WGDQVTAELT
RQLMEFQGFY SLDRPGDWMG VVDLQFLGAM MHPGGGRNDI PDRLKRQFTV LNLTIPSDVS
VDRIFGTIIE GHFCANRGFA EDVISLAAKL PPLTRKLWQA TKVKMLPTPA KFHYIFNLRD
LSRIVEGMLN TKPETVPNGQ VLVNLWEHEC SRVIPDRFTN QEDTDWFSKQ TYTMATKELG
DELGSATATK SFWADFLRDP PEVEDPDQEV DLESIKVYEK IPSWDVLRDK LTEYMKQYNE
TVRGSKMDLV LFEDAMKHIC RISRILRTPR GSALLVGVGG SGKQSLTKLA AFIAKSQVFQ
IAISKNYNLT NLMEDLKFMY KIAGAQGKSM TFVFTDNEVK EEGFLGYMNN VLTSGEVTNL
FPKDEIISIA TDLRLPMKKA RPQVLDTLEN LWQFFIDRVK SNLHVVLCFS PVGDKFRNRA
LKFPGLISGC TMDWFNKWPN EALRAVAEKF LADVELANTD QVRKDLVNHL AFTHDVVSDS
CGQYFLQYRR KTHVTPKSYL SFLSSYKVLY RQKRKEVGEL ADRMNMGLEK LLEAAKAVAV
LQEELVVKEK DLAVASKQAD AVLIEVTAST ASAEKVKDEV LKVKNKAEGI ANAIKADKTV
AETQLEAARP AIEEATAALN SIQPAHIATV RKLAKPPHLI MRIMDCVSLL QKRKIDVVTQ
DPERPCVKPS WSEALKLMSQ SDFLSSLLNF PKDEMNEETV ELLEPYLEMP DFNLEGAKKV
SADVAGLASW VKAMYVFYFI NKKVIPLKAN LIVAEHKLGL AMADLTKAQS TLDEKQAELD
VFKAKYDGAI SQKQALQADA DSCKRKMAAA TALIGGLSGE KVRWTAQSKE FAEKISRLVG
DVMLAVGFLS YCGPFNQIFR SQLINDWKKE LVRQRIPTTD ELDIIGLLVD NTTVGEWNIQ
GLPTDELSTQ NGIIVTKGTR FPLLIDPQNQ AKSWIKTREE KNKLQVTSLN HKYFRSHVED
CISQGRPMLI EDVEEALDPT LDNILEKNLI KAGRSFKVVF GDKEIDYHQD FQLFITTKLP
NPSYTPEIYA KCSIIDFTVT IKGLEEQLLG RVISREKQEL ETERAKLLEE VNSNKKKMKQ
LEDNLLERLT STKGSLVDDE SLIEVLATTK STAEEVNEKL ITAAETQKKI SVAREEYRPV
ATRGSIIYFL ISEMSMVNVM YQISLKQFLG LFDESMEKSQ ASPIPSKRIQ NIIEYCTFRC
FSYVVRGLYE IHKLMFVLLL SMKIDIQTGK ISHEEFRTFI RGGGALDINA VAKKPFNWIP
DVTWLNLVAL SKMPGFNDLL NQISKNEKLW KAWYEKDAPE NEQLPGGYSN SLDAFRRLLL
LRSWCIDRSA MMAKQYIASS MGVRFAESQV LDLDALLMES DNRTPMICLL STGADPSADI
ENLSKKYKIE IKAISMGQGQ EIHARKLLAT YMANGGWALL QNCHLGIPFM DELLGLITDS
EAINDKFRLW ITTDVTQKFP INLLQSSIKF TNEPPQGLKA GLKRTYNWLT QDMLDMSARP
QYKPILYGLA FFHSVVQERR KFGPIGWNIP YEFNQADLAA SVQFVQNHVD ELAPKAPINW
ATTRYMFSEV HYGGRVTDDF DRRLINTYAK VWFGEEMFKD TFCFYKGYII PNLKTVEEYR
TSIETLPLVD TPDAFGLHPN ADISGQTKSS QNMLDTIMSI QPKDSGGGSG ETREDAVKRL
ANDLLSKLPA DFEPHFTKQA IAKQGGIKPL NIFLGQEIDR MQAVISLVRG TLKDLKLAID
GTIIFSPRLQ QALDSLYDAR VPDNWTKISW VSPTLGLWFG ELVLRGAQFK SWLEEGRPLV
FWLSGFFNPQ GFLTAVRQEI TRNHQGWALD NVKLAPEVMK QMKEDITSPP AEGVYIHGLF
IEGAGWDRKN IRLTESQPKV IFTAMPVVYI NATNSTDDGD PRLYRCPVYK RPKRTDLNYI
FDIELKPQPN QSPDYWVLRG VGLLASTS
//
