ID A0A139HFL6_9PEZI Unreviewed; 1433 AA.
AC A0A139HFL6;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=AC579_1266 {ECO:0000313|EMBL:KXT01149.1};
OS Pseudocercospora musae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=113226 {ECO:0000313|EMBL:KXT01149.1, ECO:0000313|Proteomes:UP000073492};
RN [1] {ECO:0000313|EMBL:KXT01149.1, ECO:0000313|Proteomes:UP000073492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 116634 {ECO:0000313|EMBL:KXT01149.1,
RC ECO:0000313|Proteomes:UP000073492};
RA Chang T.-C., Salvucci A., Crous P.W., Stergiopoulos I.;
RT "Comparative genomics of the Sigatoka disease complex on banana suggests a
RT link between parallel evolutionary changes in Pseudocercospora fijiensis
RT and Pseudocercospora eumusae and increased virulence on the banana host.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXT01149.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFZO01000663; KXT01149.1; -; Genomic_DNA.
DR STRING; 113226.A0A139HFL6; -.
DR Proteomes; UP000073492; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000073492}.
FT DOMAIN 27..412
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 493..663
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 711..805
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 816..1120
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1131..1323
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1433
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1433 AA; 162950 MW; 7BF543035AEDC0D2 CRC64;
MSRPRPRPRP SPHPRPSIND LTGDHEIARI ARSTWLASPN PPKVLPHTVA ELWKLVEDEQ
FSSFSLLLLE QLQALERYLW PGYASSHEPS NHYLLLLVLL VNTKRQEHLP VWSFFANTPD
EFADFFRRVV HLSIDQSLAT HLREYLLAFL LAAYQSLDHG IVRKECAPLV SIGIWHNLHD
DATRETLLAK NTQLQKAWRA VGKKFDHADA ATQARLRLER NWLHTLVLHC FDKLYEDDKE
KEKDNVSYCE RLLELLCHLQ SQLPTRRYVN TLLRDLNLLP AILLSPMYHD EERIRDMYKL
LHHYTNFPLD DYTGRQLSRK QHDEAQNASI SRLQKVAMKL QPEKLKILIL TNFAALGQRG
HLEGHLADLT DAELLQLSQE LGMRTSEYPE KTLLVRDRAF VVESLVSVIA KRLHYAEEMR
SLRILPTEDV LYDKSMMRTE EHTPGQPLPI PKLNLQYLSV GDFLWRSFIL YRQEAFYSIR
KHIEDTVNKV QPRRGGGQTR FDGFSRMAIP IAKPAIVETV PPRVGETVLA EVKVEIILDV
SRLQPGLRRE WESLRPDDTV FLLALHPEDS AMKLTNGAAS EQSHMEKLGL KTIRCAEVIG
VLDENGKPLR FNQDQQDHID DVSRPRQRRL LLRLDALAYK ADKDREEAGK GDTYESINLI
TRRRSRENNF RPVLESIKQL ALSETPLPGW FEEVFLGTGD PSSAMYKRLP NKLNNIDYRD
TFLDWQHLIE SLPGKTVEPD PKLNAIPPPP YVLETTGAAP TIAPPKKGKK RRHDQPDGPE
PAPSAETFRV STYAPTNNGP YPTDAPKTNA VRFTPTQIDA ITSGTQPGLT VVVGPPGTGK
TDVATQIISN IYHNFPHQRT LLVAHSNQAL NQLFQKITAL DIDERHLLRL GHGEDGLTTE
LSFSKVGRVE SFLERGTQFL AEVQRLAATI RAPGAHGNSC ETAEYFNQVW VQPLWKRFWD
LVSSEGTTAE AVVSAFPFHS FFADAPQPLF PPDRQKEHVM DIAKGCERHI NRMFSELADI
RPFEILRAQR QKSNYLLVKE ARIIAMTSTH AAIRFQEIAQ LGFKYDNVIM EEAAQITEIE
NFIPFVLQIP VAKDEKSPER ENPLKRVVLV GDHLQNSPVI QHPALKSYCN LEQSLFQRLV
RLGVPHTQLD AQGRSRPSIA NLYKWRYPSL TNLAFTCTAP KFVQANAGFR YEYQFVDVDD
YKGQGESEPT PHFIQNLGEA EYAVALYQYM RLLGYPAEQV SILTAYAGQR ALIRDVLTHR
CKNNRLFGMP AWVGTVDKYQ GEQNDYVILS LVRTKSPGYL RDLRRLTVAL SRARLGLYVL
GRKQVFESNL ELREAFEPLF GKSTKLELVG NEMFGATQRL VDDVNVQNVA EMAGVEHLGQ
YVFEMTKAKI AALKEGGGQL PPPAQSGKPE DDDDDEGEVG GGFEAAEEMD EDL
//
