ID A0A139IM80_9PEZI Unreviewed; 3885 AA.
AC A0A139IM80;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AC579_1541 {ECO:0000313|EMBL:KXT15760.1};
OS Pseudocercospora musae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=113226 {ECO:0000313|EMBL:KXT15760.1, ECO:0000313|Proteomes:UP000073492};
RN [1] {ECO:0000313|EMBL:KXT15760.1, ECO:0000313|Proteomes:UP000073492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 116634 {ECO:0000313|EMBL:KXT15760.1,
RC ECO:0000313|Proteomes:UP000073492};
RA Chang T.-C., Salvucci A., Crous P.W., Stergiopoulos I.;
RT "Comparative genomics of the Sigatoka disease complex on banana suggests a
RT link between parallel evolutionary changes in Pseudocercospora fijiensis
RT and Pseudocercospora eumusae and increased virulence on the banana host.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXT15760.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFZO01000051; KXT15760.1; -; Genomic_DNA.
DR STRING; 113226.A0A139IM80; -.
DR Proteomes; UP000073492; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 2.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000073492}.
FT DOMAIN 2690..3247
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3507..3855
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3853..3885
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 164..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2130..2151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3260..3337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3772..3795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2135..2151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3274..3308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3309..3337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3885 AA; 439764 MW; 44D507BEA75C8606 CRC64;
MAERTMDAYE IKLQDASLDF KAKLPILTEL RDQLDALCQP PTYASFLSKF IPIFLTILSG
SPVFTSTSYE QRVRQCVLEI LHRLPMSSDG AAMEPHAEKI VDKCLELVRV ENEDNAVLCL
KIVMDICRYH TKTAGVAEKA QPFLDLILDI FDGMEHTVRH TFDSQSPVPA TAAGLSATPD
NTGTPGSPVA STSHALGADP GAEQNTTRQL VKGVHSFKVV AECPIIVVSI FQAHRALSGK
NVAKFTPRIK QTLLLEAGPQ KRAHDDAKAN GTIFTGIARD IKAKGQSAAF ADLVTAQVKT
MSFLAYLLRA YSSSLTDFLS HLPELTVRLL RDVPRSSTAT RKELLVAIRH IINFNFRAVF
LPVILPLLDP NTLVGDSLTA DVTLRPLAYT MLADLIHHVR EQLNAKQIAR VVQVYVGHLT
GDDGVEVPGT SYQTMSAKLL LNMAECMSKV EDKKNARFLM MSVLNGIADK FAAMNRAYPN
AVKLYRQQHG HAQSEPVPEN YLATKDAKPD WDETDIFNAM PIKAVNPKDR ATDPVTENKF
LFKNLLQGLK QFFYQLRNSN PPKIKEEIDT ASAPPHWNEL SSGFEAEEVE VLIKLFREGA
KCFQYYAPLD TAADNSLPSE PSSSMATTAN SKEEKDLLET FATIFHHLDP ATFHEIFTSG
NPSGIAFLYT QSFKHSALLH IPQFLLASEA TSPAFCGMLL KFLMSKLDEV GEADPSTTSV
LLRLFKLSFM AVTLFSQHNE GVLLPHVREL ITRSIELSIT AAEPTNYFLL LRSLFRSIGG
GRFEHLYKEI LPLLEMLLEV LNTQLAAAPD GSTRDLFVEL SLTVPARLSH LLPHLSYLMR
PLTVALRSGE PLSASSQRPS SNDRSSHDNR GGGSSELTAQ GLRTLELCVD NLTADYLDPI
MQPWMEEIMG SLWRMLKPAS LTGGSITGPN GPVTIGTGHQ GAHTAVRILG KLGGRNRKFL
VNPPELDWKQ YSDDEASYDL RFIGAISSGG ARAMPARLGI DSAIDKLWET PKTAAQKASD
EHHKRQSFKL ITSHIKLLIG PDNLPDDLAR LVRLQANDLA SKDFDFGSDL FSASERSKST
IKRDEQQKTL LRLLKAVIYA TSIEQLKEDA DQFLLGICRH FMLVELGVAV AREKHNRRPF
NVHSGEGPVF VETSTLAEAF CESLASDQKT VRDTTERAMQ SCLKFASTIF GSSIKAECLP
FFSRLSEAFC HACYEEEWFT KNSGALGITI LADGRRMQFS DSFTNDRLSE MLKALLFVIK
DMPQDLPANI RVQAKDTIVA LVKRFGGSGA EKKDELEKKE SKLHGHAKYL ISEVNHMNRH
VREAAQSALR ALAASFDLPH HELLAPVKEA LTFGIFIKPL RALPFAAQIG YIDAINFLLD
VPLDKEILPF DDNLNRLLFE TLALVDADDE SLAPKPYEFR TAENIVRLRV AGLKLLATAI
KLPGFSANAT PGPPNQQGQP QSGQHRARVI SIFFKSLYSK NKDVAGAANA GLKIVLQSTS
KLPKDLLQNG LRPILMNVQD PRKLSVEGLE GLRTLLQLLH NYFKVEIGTR LLDHMEKIAD
GPTLQKVSFQ LIEAQPKMKV VTAIFSVFHL LPSQAAQFLD DLVKRVLKLE EALRRTRSSP
FREPLIKYLN HYPNESWTYF RDEMKNDAKG RFFAQILEDP ESATLREKVI KEAEGLVGTF
KANHLDPDKA HAAVNAIHIA YAICHFPEHA KQLLSNETTR KALLEATKQL QKKLHDHTLP
ENLRLAVMQA AEQIMHIMTA YLGDHKDDLE CLFGIFESCV QDELPATPTL IAYLYKHVIT
VDDVEYQRSI VNRCIDIYTS RDTPQKLKWF VFHNVSNPIL ANDVSRNWNS LMEPDDNGTA
LFDKAMANAV HNKLWRPQSV ADISDDNTQG VDHSRMELLQ TSAFLIKYHH SMLQETRKDL
IKFGWNYIRL EDHINKFASY CLITYFINNY DTPPKIAMQV YNSLLRAHQA EGRNLVSQSL
EILTPVLKKR LGGPEGRQSI WARLPRKILS EEISNIPQLT SIYHFLVRHP DLFYEARDGF
AQIIIPSISK VVQLPNPSVD SRRLALNLFT LIWQWEERTV REHGSLAGGE STADGKQNPK
KAAVANSALR LVLIKYMVQF IATLPERFPV SPPKSKDSPA SSGQQQQPHE TVTKSLDLLS
KLLSPPYWDD LDIDTMFPKV TEQILCTDHK QEEKVEIWTT RVVNTIQVLK VLLNSRPDEW
VIARLSQLQK LLVKPLKSET PDIQDALHNA DFQEHVVPKL PPILKRALDP IPVQAPDDEL
PDADSPTEEF TGFLTTEAGN LLNNGSHVAG INILWIMAQR KPEDVDTHTA ALLKTLQTKL
AKDHLAALMH PQQMMAQGMQ NAQPTPQEAQ ITVDMIIKVI EMLSARISTL GESRRPYLSV
LASLVERSTN NALCEKILSQ VENWVFNSPE PVPTLKEKTA VLQKMLLFES RPDQALYTKF
MNLVIRIYED PKITRSELAV RMEHAFLIGL RSPDIDMRTR FMGIYDKALS RSTSNRFYKL
ISEQQWDVLG DSFWLSQVIQ LMFGSFDHHA PIHLHQEDFK CLPESKAIGT YISDTRVNDI
MVDDSLEELM VDEKRFMMEI STVRAREVLV PLAEIQHTDW TLAHDIWVAY FKMCWSILPK
DDRDDIEQGL VALLTKDFHQ RQIDRRPNCV ATLLEGIAAA RPPVKFAPHV MKYLAKSYDA
WYVAATYMED LAMKPTVDTT NVRESNLDAL VETYAGLEES DLFYGTWRRR AAYVETNAAL
SYEQNGVWDK AQNMYEQAQV KARTGSLPYS QGEYMLWEDQ WVLCAQKLQQ WDILGEFAKH
ENINDLYLEA MWRNYETWQN AENRDHLETV IKAVSDAPTP RRMFFQAFMS LLKLHNKTEQ
PQEFNRTCDE NIQLSIKNWH KLPRRITNAH IGLLQNFQQL VELHDASVIC QSLAQTNATN
LDVKSQELKV LLSTWRDRLP NLWDDINAWQ DLVTWRQHIF QLINGTYLNL IPSGQGAATG
NSYAYRGYHE TAWIINRFAH VARKHQMPEV CITQLSKIYT LPNIEIQEAF LKLREQAKCH
YQNRAELTNG LDVINNTNLN YFGQQQKAEF YTLKGMFLSK LNQKDEASDA FGTALFFDIK
LPKAWAEWGR YNDKLFKEDP TNLETGSNAL SCYLEAAGQY KSAKSRKLLS RILWLLSLDD
ADGQLSQKFY DYHGDHPWWY WVTFIPQLIA NLSRTESEAS IAHQILTSLA KTYPQALHFS
LRTSHEDHQA IRKSLMLREQ KEKAMKAKQA GGAASSDNVK SESPARPDSS AGQSRPTTSA
GETSQAPTDG ETKTDEKKEG GSEEKKEGEA PKPRKSWEHT EALVITLRTA FPLLYASMEA
MVEQIQRHFK CPPDEDAYRL IVALLNDALS YVGRSPQSFS QDNKLPPQTE ANITRFAESI
LPPHIRKSFE QDFVTKKPTM LEYIGKLRRW RDKLAERLDR RSTTFHLAEN THLAGFRFVW
FDEVEIPGQY LQHKDKNQDF VRIERFLPNV DLVRGVASCH RRLKIRGHDG SVHPFAIQHP
APRHSRREER ILQLFRIFNS TLSKKKESRR RNLQFHLPVM VPLSPQIRII QDDPSYTSLQ
AVWEDYCRRN ETDKDQPTMF TMEKMRSITP NQRQEQWLNM RIESLNYVQE HYVPKDLARD
YFAATFPSYD SFWLFRRQFS YQLAALTYIT FTMFMTVRYP NKMHISRSNG NIWGSELLPF
MLANRPLFHQ PESVPFRLTP NLQVLMGPIH TEGIFTCALM AIARCLTSDA SSSTTSSATP
ATNGATQTNG ASESSNSELE HHLSIFIRDE IAFWYMSSHR QNVKEGEMRE HVQRNSEAIV
GKAVGLAREP TGHNLPASQS VLDLVAKATN PEKLSQTDLL WMPWL
//
