ID A0A139NRQ2_9STRE Unreviewed; 801 AA.
AC A0A139NRQ2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=CRISPR-associated helicase Cas3 {ECO:0000313|EMBL:KXT78404.1};
GN ORFNames=STRDD11_02417 {ECO:0000313|EMBL:KXT78404.1};
OS Streptococcus sp. DD11.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1777879 {ECO:0000313|EMBL:KXT78404.1, ECO:0000313|Proteomes:UP000070514};
RN [1] {ECO:0000313|EMBL:KXT78404.1, ECO:0000313|Proteomes:UP000070514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD11 {ECO:0000313|EMBL:KXT78404.1,
RC ECO:0000313|Proteomes:UP000070514};
RA Denapaite D., Rieger M., Koendgen S., Brueckner R., Ochigava I.,
RA Kappeler P., Maetz-Rensing K., Leendertz F., Hakenbeck R.;
RT "Highly variable Streptococcus oralis are common among viridans
RT streptococci isolated from primates.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXT78404.1}.
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DR EMBL; LQRF01000350; KXT78404.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139NRQ2; -.
DR STRING; 1777879.STRDD11_02417; -.
DR PATRIC; fig|1777879.3.peg.2752; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000070514; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47957; ATP-DEPENDENT HELICASE HRQ1; 1.
DR PANTHER; PTHR47957:SF3; ATP-DEPENDENT HELICASE HRQ1; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 8..215
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 492..652
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 801 AA; 91327 MW; 09B4C222024CC656 CRC64;
MILAHKDDYG NKQSLKEHSF NVAVKAREDA KLIGQGDVLF LLGLYHDLGK ANQAFQYKLT
KDPNKHVDHS SAGARYLFET IQKCLKRLFV PTAERRLFQE IAAYVVSAHH GMYDIPLADV
SVKPELFAFN KLRYRIVDGI ANEAYQGDIL PFAQGLEDEL DMYGYDGLND LIEKAFTNYQ
QAWAKLDCSD KSEEAYYSGC FVRLYLSLLK NSDILDTINA YGLLITPLKQ EERNHLNKSY
LEAIEKKYGE FGNPTTRLNE IRSQIAERVK SRGENDSTGI YRLDLPTGAG KTNLSMRYAF
HQLVDQNKSN FFYITPFLSV LEQNAAEIRK ITGDEGVLEH HSNVVTQNDD KDDDGNERLL
SDYLIDTWDS PIVLTSMVQF FQTLFKTKSA NIRRFSNLAN SVLVLDEVQS LPIEVTTLFN
LTVNFLNKVM NTTIILCTAT QPAYDSNTIA HKIYYGGKFG ETADIVELTI EEREVFSRTE
LRKFDEDNQY SKLSDLVDFV LENNESILAI FNTKKTVDKF YTILEGLTDR PIYQLSTNMC
AQHRLDVISE MKQQLKDGLP IICISTQLIE AGVDVDFNRV IRSYAGIDSI VQASGRCNRE
GKRDKGQVTL VNLTNEEENI SRLKEIRSKK CAAEYILHKI SSPLEISLLN RDFFEYYYAN
NQNSMDYPLS HGEAVYDYLS VNSYQDRKNF KGKLKQAFKS AGLKMNLINN DTIGILVPYG
AAVEKLQFLE ELCESDYPAE EDYQTIKNLL KGLQLYTVNV REHDPILEAT KTYLNGQIQI
LSNGYYDEKK GITLETGSFL L
//
