ID A0A139SHL2_9BACT Unreviewed; 890 AA.
AC A0A139SHL2;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AXK12_08045 {ECO:0000313|EMBL:KXU34039.1};
OS Cephaloticoccus capnophilus.
OC Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae;
OC Cephaloticoccus.
OX NCBI_TaxID=1548208 {ECO:0000313|EMBL:KXU34039.1, ECO:0000313|Proteomes:UP000071392};
RN [1] {ECO:0000313|EMBL:KXU34039.1, ECO:0000313|Proteomes:UP000071392}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV41 {ECO:0000313|EMBL:KXU34039.1,
RC ECO:0000313|Proteomes:UP000071392};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXU34039.1}.
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DR EMBL; LSZP01000062; KXU34039.1; -; Genomic_DNA.
DR RefSeq; WP_068713227.1; NZ_LSZP01000062.1.
DR AlphaFoldDB; A0A139SHL2; -.
DR STRING; 1548208.AXK12_08045; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000071392; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000071392}.
FT DOMAIN 730..746
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 851..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 656..663
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 890 AA; 97756 MW; A9A0CB9E43BDDF6D CRC64;
MSDSKPAAKL TPMMEQYFEV KRGLPDGTLL LFRLGDFFEL FYEDAVIASR LLGLTLTKRQ
DYPMAGLPYH AADSYITKLL AAGRKVALCD QSGPVQPGKL VKRALTRILT PGTTLAASQL
DANRNHYLCA LSHDKRGLHA AWLDLSTGEF RIASDTQIES LLPVLTALSP AELVLAEGIF
SKWEAESQAH HDAGHADLRS LYHFCADHTR SEIPNYHFEP RAGAKTVMDT LGVLNLEGFG
ISPEHSALGP AGALLYYATE TLRARPENLR TLKEYRSSGT LLLDPATLRN LEIFSSSRGT
REGSLLDAIN RTRSATGARL LERWLSAPTL ELHEIHRRQV LVGEFAAQPS RLSALQDSLV
QVRDIPRILG RLQNRLRNPR ELAGIRDTLA QFPKIRAVLA DWNSPSANSS SPEPKRLAAE
YADRIAALPD LLALLSRALA DELPGDVADG GMIRPGHDAE LDRLRSLTTN NKTWLSALET
TEQQRTGIKS LKVKFSNNFG YFIEVTKANL HLVPTDYIRR QTTVGGERYV TEKLREKEKE
IFTAEERALA REQDLFHALV SSVLAEADAL SRTADALAEL DVLAGWAALA REWDYTRPTV
DDSDQLLIEE GRHPVVEQML KSPQAAASAS ASSSAAFVPN DTELCASGAQ LALITGPNMA
GKSTYIRQVA LIALLGHIGC WVPAKSCRIG LIDRIFSRVG ASDDLARGNS TFMVEMNETA
NILNNATRRS LIILDEIGRG TSTYDGLSIA WAVVEHLHSD PQAGPRTLFA THYQELTQLE
KHLPRLRNLS VTVKEWNDEI VFVRRVQPGA ADRSYGIQVA RLAGLPLSVI DRAKEILSRL
ESDEAVVALP ATTSAAAPHP APSSPEPKLP PKPKKKLTVE PIDDPQLSLF
//
