ID A0A139SI68_9BACT Unreviewed; 1210 AA.
AC A0A139SI68;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=AXK12_07880 {ECO:0000313|EMBL:KXU34184.1};
OS Cephaloticoccus capnophilus.
OC Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae;
OC Cephaloticoccus.
OX NCBI_TaxID=1548208 {ECO:0000313|EMBL:KXU34184.1, ECO:0000313|Proteomes:UP000071392};
RN [1] {ECO:0000313|EMBL:KXU34184.1, ECO:0000313|Proteomes:UP000071392}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV41 {ECO:0000313|EMBL:KXU34184.1,
RC ECO:0000313|Proteomes:UP000071392};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXU34184.1}.
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DR EMBL; LSZP01000060; KXU34184.1; -; Genomic_DNA.
DR RefSeq; WP_068713162.1; NZ_LSZP01000060.1.
DR AlphaFoldDB; A0A139SI68; -.
DR STRING; 1548208.AXK12_07880; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000071392; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000071392}.
FT DOMAIN 626..787
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 809..962
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1148..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 133785 MW; 452174A27BE81826 CRC64;
MSKARAQVVS GVCPPARGLA LAELIAAHPE QTLWLVVAPD AKTAEHLAED IPFFQNLGEA
RSTKTRASAC DREHAPKKKR AAPPRPIIEA ATFPEAMPDT RDMRDAFAAS SQRLAVLSKL
RELRATVAGD STRRRSAPLD ARAGAPLVVL CTLPALLQPV PALEALSSRE ITLRTGQAQP
FAGLLEQLQA LDYDCEALCE APGHYAVRGG IIDLYPITAT QPYRVDFFGD EIESIRLLDP
VTQRSGSPVE SITLSATPRV KLDPARSGLA DYLPADHTAL VFIEAAELDE VFRRETTSEG
EGQADPLETL STIRAKAALS ISLCEIEQES ELFPTPPHDA EGPARPSLDK RVCDPLALHR
RYPTEALLAH ERVAAEADAR RDFLEQLVQW QRDGYALHFV ASRDGEAQRM TEILEEEGLA
KTLRVQTHIG SLNEGFLYRS GADSSPRRLA FVTEVEIFGR QRARRPRATT QQVAQRAQID
QLLDFSELVE GDYVVHLQHG IAHFRGLATL DTAQGPREVI SLEFDEQVTL HVPLQESHLI
SRYVGLTKVR PQLGKIGSGR WEKTRKAAER ATIDLAAELL RIHAAREAQP GFACPADTDW
QKEFEASFPY TETRDQLRAI EDTKADMERT RPMDRLICGD VGFGKTEVAI RAAFKAVQGG
RQVALLVPTT VLAQQHLNTF RERMAGYPIV VEMLSRFRSR KDQQAILAAT AAGQVDILIG
THRLLQSDVA FKSLGLLIVD EEQRFGVKHK ERFKALRATL DVLSMSATPI PRTLYMALTG
ARDLSVIETP PADRHPIHTI VKTYDEKLVA EAIHQELRRG GQVFYLHNRV QTIDLIAARL
RELVPGARVG VGHGQMEPTE LERVMTDFVA GTYQVLVCTT IIESGLDIPN CNTIIIESAD
RFGLSQLYQL RGRVGRFKHQ AYAYLLLHRH SRLLDIARQR LGAMRQHNQL GAGFRIAMRD
LELRGAGNLL GSQQSGHIVG VGFELYCQLL RQSVARLKGE AQAAAIRATV KLDFVVVGDD
RETAETKAGD DLRPTRRTQN KGQFVSGYTA LRDAEHAAAP PLAPIRACLP ANYIPETRLR
IDFYRRLALA GSSAQLKEIA AELRDRFGKF GEPVNALLTL TEIRIRAEQK GILSVETEGA
KLKCLRAKPL NTPSAPPGRA SNGSPPNNPA KQPWVQHGTR FPRLTAPKPL LRLREILIFL
NNLPDSPPNS
//
