ID A0A139SWH3_9GAMM Unreviewed; 273 AA.
AC A0A139SWH3;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=glucose-1-phosphate thymidylyltransferase {ECO:0000256|ARBA:ARBA00012461};
DE EC=2.7.7.24 {ECO:0000256|ARBA:ARBA00012461};
GN ORFNames=AXE65_00810 {ECO:0000313|EMBL:KXU38751.1};
OS Ventosimonas gracilis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Ventosimonadaceae; Ventosimonas.
OX NCBI_TaxID=1680762 {ECO:0000313|EMBL:KXU38751.1, ECO:0000313|Proteomes:UP000072660};
RN [1] {ECO:0000313|EMBL:KXU38751.1, ECO:0000313|Proteomes:UP000072660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV58 {ECO:0000313|EMBL:KXU38751.1,
RC ECO:0000313|Proteomes:UP000072660};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the formation of dTDP-glucose, from dTTP and
CC glucose 1-phosphate, as well as its pyrophosphorolysis.
CC {ECO:0000256|ARBA:ARBA00037065}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate +
CC dTDP-alpha-D-glucose; Xref=Rhea:RHEA:15225, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:57477,
CC ChEBI:CHEBI:58601; EC=2.7.7.24;
CC Evidence={ECO:0000256|ARBA:ARBA00001095};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the glucose-1-phosphate thymidylyltransferase
CC family. {ECO:0000256|ARBA:ARBA00010480}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXU38751.1}.
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DR EMBL; LSZO01000079; KXU38751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139SWH3; -.
DR Proteomes; UP000072660; Unassembled WGS sequence.
DR GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR005907; G1P_thy_trans_s.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43532; GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43532:SF4; GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 2; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000072660};
KW Transferase {ECO:0000313|EMBL:KXU38751.1}.
FT DOMAIN 30..263
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 273 AA; 30375 MW; 4797AA8556F0177E CRC64;
MQNRPCIISR LLPASPQSFL STPNLLLFMK GILLAGGLGT RLYPLTRNTN KHLLPVNGKP
MIYYPLSTLI LAGIHDILLI STPRDLPTFK QLLGDGSSFG VTLSYAEQPS PDGIAQSFII
GEDFIGKDPA CLILGDNYFA GDGLESLLKK AAAHTEGASV FAYPVDNPEQ FGVIELDNEN
RPISIEEKPK YPKSNLAVTG LYFYDNRVVE MAKQVKLSKR GELEINGINE NYLQQKKLFV
QVLKQDFTWR DMGIKTSYQK SNKISKETLQ NPH
//
