ID   A0A139SXD9_9GAMM        Unreviewed;      1163 AA.
AC   A0A139SXD9;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=AXE65_00640 {ECO:0000313|EMBL:KXU39071.1};
OS   Ventosimonas gracilis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Ventosimonadaceae; Ventosimonas.
OX   NCBI_TaxID=1680762 {ECO:0000313|EMBL:KXU39071.1, ECO:0000313|Proteomes:UP000072660};
RN   [1] {ECO:0000313|EMBL:KXU39071.1, ECO:0000313|Proteomes:UP000072660}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CV58 {ECO:0000313|EMBL:KXU39071.1,
RC   ECO:0000313|Proteomes:UP000072660};
RA   Wen L., He K., Yang H.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXU39071.1}.
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DR   EMBL; LSZO01000046; KXU39071.1; -; Genomic_DNA.
DR   RefSeq; WP_068387564.1; NZ_LSZO01000046.1.
DR   AlphaFoldDB; A0A139SXD9; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000072660; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR048472; DNA_pol_IIIA_C.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000072660};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          6..73
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1163 AA;  128955 MW;  58FDDC7F89CEA5F6 CRC64;
     MSATFVHLRL HSEFSLNDGL VRVAALAEAV AKAGMPAVAV TDQSNLHGLI KFYKATHKLG
     IKPIVGADIW LSAATDDGAL SKLTLLVMNQ TGYRNLTELL SQSWLKGQQE GIAVTQRDWL
     QGATDGLIAL SCSREGDIAA ALRTADETAA ETLLKYWQAL FPGRFYLEVQ RSGRDGDEDH
     LHAAASLAER TAVPLVATCD VRFLRQDEFE AHEARVCIGE GRILDDPQRP RPYCDQQYLK
     TPEEMAELFA DLPEALANTV EIAKRCNLEL RLGKAVLPDF PTPNGMSMDE FLRHSAKEGL
     LQRLAAHGTG GRPQQAYDER LEFELATIIQ MGFAGYFLIV ADFIQWAKNH EVPVGPGRGS
     GAGSLVAWVL GITDLDPLAY DLLFERFLNP ERVSMPDFDV DFCMDGRDRV IEYVANKYGR
     EAVSQIVTFG SMAAKAVVRD VARVQGKSYG LADRLSKMIP FEIGITLEKA RAQEEPLREF
     LEKDEEAAEI WEMSLQLEGI TRGTGKHAGG VVIAPTKLTD FTPLTCDEDG SGLITQFDKD
     DVEAAGLVKF DFLGLRTLTI IKWALSTIHR EQKKQGVPEA DWVNIEKIPL DDAKTFAMLQ
     RGETTAVFQL ESRGMRELVK KLKPDCLDDL IALVALFRPG PLQSGMVDDF INRKHGKAPL
     AYPHPDYQYQ GLKPVLESTY GIILYQEQVM QIAQVMAGYS LGGADMLRRA MGKKKPEEMA
     KQRGGFIEGC AKNGIDGNLA ANIFDLVEKF AGYGFNKSHS AAYGLVAYQT AWLKAHYPAP
     FMAAVLSAEM HNTDKVVIMI EECRSMKLVI EPPNVNRSDY QFTVNEQGQI VYGLGAIKGV
     GEGPVLSIQN SRAKDGEFKD LFDFCQRIDR RSLNKRTLEA LIRSGALDAL APDKTDLDQG
     RAILLASMDE AVQAAEQSAR SRESGHQDLF GSLLSESAAD VYQNARKAPP LSISQRLEGE
     KDCLGLYLTG HPIDEYEAEI RRFAPERIAR LKPSRDTQKV AGLLLSLRVT KNKKGEKMAF
     ITLDDRSARI EASLFGEQFS EHQDLLHSGA LLVVEGEVSQ DDFNGGLRLR SSKLMSLAQM
     RSSQVQSLCV QACNETLMPK YLPQLAELCR KYPGSCPVTV DFRGKNARAR LRFGENWRIE
     PCENLLRSLR TQFGKTQVSL HYR
//