ID   A0A139TTQ1_9BACT        Unreviewed;       669 AA.
AC   A0A139TTQ1;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HMPREF3039_00767 {ECO:0000313|EMBL:KXU55042.1};
OS   Akkermansia sp. KLE1798.
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=1574265 {ECO:0000313|EMBL:KXU55042.1, ECO:0000313|Proteomes:UP000070454};
RN   [1] {ECO:0000313|EMBL:KXU55042.1, ECO:0000313|Proteomes:UP000070454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLE1798 {ECO:0000313|EMBL:KXU55042.1,
RC   ECO:0000313|Proteomes:UP000070454};
RA   Wen L., He K., Yang H.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXU55042.1}.
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DR   EMBL; LTZM01000022; KXU55042.1; -; Genomic_DNA.
DR   RefSeq; WP_067572075.1; NZ_KQ971075.1.
DR   AlphaFoldDB; A0A139TTQ1; -.
DR   PATRIC; fig|1574265.3.peg.742; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000070454; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF3; ATP-DEPENDENT HELICASE_DEOXYRIBONUCLEASE SUBUNIT B; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          24..308
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          309..583
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         45..52
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   669 AA;  75880 MW;  1BCAE209667DEDAF CRC64;
     MARRYVIKQD SAPSAPISGI DYHATLNEEQ YAAVSSEPGA ALVIAGAGSG KTRTLTYRVA
     WLLDNGTDPW NILLLTFTNK AAREMTERVR ALIPIDLSRL WSGTFHSIAN RILRQHADYL
     GYTPAFTIMD SDDRKSMIKS IVKALKLDEK SSRFPKPEVL SSLFSLADNE GAGIQETLEN
     AYPYLSNHLD AILDVHEQYV LRKQETNSMD FDDLLLNVVR LFQEQEHLRA LYGARFHHIL
     VDEYQDTNYL QSRFIDMLAR EHGQLMVVGD DAQSIYSWRG ADMENILSFT TRYPSAKTFK
     IETNYRSVPE ILELSNAAIA ANEMQIEKRL RSVRPTGEMP PALVPLNDDR MQAKFISQRI
     RDLIEEGTDP NEIAVLYRAH FHSMELQMEL TRSEIPFRIT SGIRFFEQAH IKDVVAFMRF
     VVNPRDELSF RRMVMLLPGI GPGMAQKLWA RWAACPESRA ETPPESFSAL MMEFPVPAKS
     KPGWMQLCYT LDELAPGGKT ANPASMLVSI NEAVYDEYMQ SAFENYDQRR QDLLHLAGFS
     ERFDSAEDFL SQLSLLGNTD DESAAADLSG GAVTLSTIHQ AKGLEWSVVF LIGLCDGMFP
     HQRVIDDGDL AGLEEERRLF YVGITRAKDQ LYLTYPRWNC RAQGGTFMQM PSRFLDEVPA
     ALVEEWEVE
//