ID A0A139W8K1_TRICA Unreviewed; 797 AA.
AC A0A139W8K1;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Regulatory protein zeste {ECO:0000256|ARBA:ARBA00016807};
GN Name=AUGUSTUS-3.0.2_15970 {ECO:0000313|EMBL:KXZ75599.1};
GN ORFNames=TcasGA2_TC015970 {ECO:0000313|EMBL:KXZ75599.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KXZ75599.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KXZ75599.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75599.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KXZ75599.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75599.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene
CC expression), where the synaptic pairing of chromosomes carrying genes
CC with which zeste interacts influences the expression of these genes.
CC Zeste binds to DNA and stimulates transcription from a nearby promoter.
CC {ECO:0000256|ARBA:ARBA00025466}.
CC -!- SUBUNIT: Self-associates forming complexes of several hundred monomers.
CC {ECO:0000256|ARBA:ARBA00011764}.
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DR EMBL; KQ973247; KXZ75599.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139W8K1; -.
DR EnsemblMetazoa; TC015970_002; TC015970_002; TC015970.
DR eggNOG; ENOG502S02I; Eukaryota.
DR InParanoid; A0A139W8K1; -.
DR Proteomes; UP000007266; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:UniProt.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:UniProt.
DR GO; GO:0008406; P:gonad development; IEA:UniProt.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IEA:UniProt.
DR GO; GO:0007526; P:larval somatic muscle development; IEA:UniProt.
DR GO; GO:0045476; P:nurse cell apoptotic process; IEA:UniProt.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IEA:UniProt.
DR GO; GO:0045467; P:R7 cell development; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18315; BTB_POZ_BAB-like; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR23110; BTB DOMAIN TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR23110:SF111; PROTEIN TRAMTRACK, ALPHA ISOFORM-RELATED; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 295..361
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 104..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 90589 MW; 89BCFA97A03E2341 CRC64;
MGDNPVRKVR KSNFSTDEVD VLVDSVRANY GILYGLNAKR ATNRWIRQKA WLDILGRVNG
VSVEKRTLQE VKNKWKKCQY ALKEKGQGAL GDDAGDSPWE DYVGRPARSP APRSPLLHSP
PAAMRRNSRH RRQLYNAYDL DLKKSVVIFA EANGNKEAQA RYGISEANIR RWRRLKDDLF
GRPRDYDRGN LRVRRRVNYT KTKTEKEEDC SSVDSMPLQE RLSKMAAQER IAGQVLKSQP
LSPTKLKVTR QAPRALKPPE PPQSPVNEEM CLRWNSHHSN MQTAFPSILS KEQYVDVTLA
AEGKTLKCHR LILSSCSPYF EEILSGISPL QHPVLFMKDI PFWILKSLCD FMYAGEVHIF
QNKLEELLTV AEALKIKGLA GKSTPPDPQS ENKETKKKNS QGKHHSTPIR KHPIYNQNSF
ESTSQDYDDD LLDPLDLLEP LYEEAAEEKK PAVTKPKENK YQYQPVKKPF GRRLRKRKFS
EPQTREPSPP PVFSFRKGTR SRPNVKIPKY YHPDYTNPPK PVISSQTDPL LDVDEIKTEP
IDVEDNMIDY SDEDHYMENS LETANCDSPI IITSAKPDKF KKIKLSKPII TEVHSVKETN
PPPGGLEVIK LTMPQPEEGD KEEVVPEPEP EQEEPLQNVV IERTEGGVEE TEKIVEHEGQ
VTENGADEEK QDGESEVPVQ NIQIESVVSA ENGAAFAEEE EEEVKQDGGG EIPVQNLQLE
NVTSSENGAE EKQDGDNEVP VQVIQIENVR SEQDQEFQEE EERRTASLNH LEKEAMSVAD
AITMENQTDP PDIEEKV
//
