ID A0A139W940_TRICA Unreviewed; 1953 AA.
AC A0A139W940;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=AUGUSTUS-3.0.2_34203 {ECO:0000313|EMBL:KXZ75806.1};
GN ORFNames=TcasGA2_TC034203 {ECO:0000313|EMBL:KXZ75806.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KXZ75806.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KXZ75806.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75806.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KXZ75806.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75806.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ972691; KXZ75806.1; -; Genomic_DNA.
DR EnsemblMetazoa; TC034203_001; TC034203_001; TC034203.
DR InParanoid; A0A139W940; -.
DR OMA; IIKVLQC; -.
DR Proteomes; UP000007266; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR CDD; cd09077; R1-I-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 2.
DR SMART; SM00343; ZnF_C2HC; 3.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50878; RT_POL; 2.
DR PROSITE; PS50158; ZF_CCHC; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 1..89
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 840..854
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 863..877
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 1412..1684
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 342..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1273..1300
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 342..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1953 AA; 221220 MW; 0EE3E653109799BD CRC64;
MPVGVRTLAF ADDLAVLVSS RNEEEMMALV NQTLQKVAEW MEDTGLSVAA HKTEATLLTG
RRRPREIKFS LMGEDISPQT SIKYLGVRLD KELRFAPHVE EVAAKAERTM AALSRLMPNT
GGAKPYRRRM LVAVARSQIL YGAEIWGSRH LKSKSLEKLE RAQRTALLRV TSAYRTTSNE
ALQVIAGTKP MALAIEERVE IRRMGPGARK AVEDRTRRKW QAAWQNAQNG AWTRKLIPDI
GPWLDRKQGH TDFYLTQALT GHGCFGTYLH RIGKTADERC WFCGEDRDDP EHTLFLCERF
DGERLEYMKK TLTWPNAEEF VEVMLSSEEN WASTSQLVRS GQVRSGQVRS GQVRSGQVRS
GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS
GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSREQKQ GVDATAQSTD DDKESIRREI
LTQMDRPGTY AEVERVLNLE WPQDVYQATK VIKGSPLAAS RDWDLGIFLN EEDGGLDTTA
MGRLFKERYP ELVEEEEEQD DISYIVQTTK FKSKVNTKYV WKIRIEKSMT NWEDKALNAE
ILKKLRDIAD AMQVEGRVKV AIPIPPRASL DQLRKLAEIA FRNKGRELAI HVPQNFTVNG
ISTANPNPKQ TKRRGVEKQT GALIVRKPGC EYIDLLKKVK KTLGNSENLK IYKALKTNKG
DLLIVTENNE EALANARKTI VEEDNAISVT ISRPRGEGME LHIGNIEADI TAEQISEAVG
KKMEVQPQEI VVKALRKGPA EMQVATIQVK KDLGESLLTQ RQIRIGLCLC TTTEKVELVR
CYKCWGQGHI STKCSGPERK NLCRKCGKPG HKISDCRGNE YCLQCNEEGH RTGSNKCPVR
RKEVRKLIRS ISTAKNGHPP QTEEKHMSQM ETEEVVPPDT PCVSTGLPSD SLRLRGGGGR
GRPTGRPDII KVLQCNLNRS REAFQLLHGT VHDRQIDIAV VAEPNKKLSE MGPWTLDRRK
DVAIRQFNKA EALRKHIGNG FVGVEYRGYA LYGCYISPNS TLDEFKQLLR ELEGHLNSSG
EECIIVGDFN AKSPAWGSKK EDERGRILMD WIAQRDYTIQ NTGDEPTFVR GESVSNIDLT
ITSNGLADKI KNWKVLPEEN LSDHRDIYFE ICKTKEENEA RTKRVRKSWK IDGEGLNIYR
ELVRKEISGR GRHWSTGTLM QKIEEMCNSS FATCRGGHPA HKRPVYWWNR DIAEQRAKCL
KARRTLGRGR KCRKTTSEQI QQLEDRYRMT KKELRGHIKK AKQTAWKELI EMIEEDPWGK
GYKVAMGKFR KETPPSKEET KEAVKKLFPR RERTVWQKEP CQEKIEFSEQ ELRDAASRLR
VKRAPGPDGI QAEIVKLVVE EATSDVLAVI NASAGKGEFP TRWKEAKLVL IPKTKQDSEG
IRKFRPICLL DIMGKLFEHL IRSRLEKELD EKGGLADSQF GFRKGRSTLD AMEEVLKFAE
TANRGTWGRK DLCAIVAIDV ENAFNSAPWK KIIEALEGKR INKALLALIQ DYLQDRGILV
GEGEEYVEMT CGVPQGSVLG PTLWNVLYDA VLRLEMPVGV RTLAFADDLA VLVSSRNEEE
MMALVNQTLQ KVAEWMEDTG LSVAAHKTEA TLLTGRRRPR EIKFSLKGED ISPQTSIKYL
GVRLDKELRF APHVEEVAAK AERTMAALSR LMPNTGGAKP YRRRMLVAVA RSQILYGAEI
WGSRHLKSKS LEKLERAQRT ALLRVTSAYR TTSNEALQVI AGTKPMALAI EERVEIRRMG
PGARKAVEDR TRRKWQAAWQ NAQNGAWTRK LIPDIGPWLD RKQGHTDFYL TQALTGHGCF
GTYLHRIGKT ADERCWFCGE DRDDPEHTLF LCERFDGERL EYMKKTLTWP NAEEFVEVML
SSEENWASTS QLVRNIIRTK EREELRREGR LPT
//