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Database: UniProt
Entry: A0A139W940_TRICA
LinkDB: A0A139W940_TRICA
Original site: A0A139W940_TRICA 
ID   A0A139W940_TRICA        Unreviewed;      1953 AA.
AC   A0A139W940;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   13-SEP-2023, entry version 23.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=AUGUSTUS-3.0.2_34203 {ECO:0000313|EMBL:KXZ75806.1};
GN   ORFNames=TcasGA2_TC034203 {ECO:0000313|EMBL:KXZ75806.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:KXZ75806.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:KXZ75806.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75806.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA   Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA   Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA   Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA   Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA   Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA   Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA   Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA   Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA   Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA   Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA   Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA   Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA   Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA   Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA   Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA   Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA   Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA   Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA   Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA   Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA   Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA   Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA   Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA   Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA   Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA   Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA   Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA   Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA   Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA   Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA   Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA   Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA   Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:KXZ75806.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75806.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT   for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
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DR   EMBL; KQ972691; KXZ75806.1; -; Genomic_DNA.
DR   EnsemblMetazoa; TC034203_001; TC034203_001; TC034203.
DR   InParanoid; A0A139W940; -.
DR   OMA; IIKVLQC; -.
DR   Proteomes; UP000007266; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR   CDD; cd09077; R1-I-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 2.
DR   SMART; SM00343; ZnF_C2HC; 3.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   PROSITE; PS50878; RT_POL; 2.
DR   PROSITE; PS50158; ZF_CCHC; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          1..89
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          840..854
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          863..877
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          1412..1684
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          342..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          936..965
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1273..1300
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        342..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1953 AA;  221220 MW;  0EE3E653109799BD CRC64;
     MPVGVRTLAF ADDLAVLVSS RNEEEMMALV NQTLQKVAEW MEDTGLSVAA HKTEATLLTG
     RRRPREIKFS LMGEDISPQT SIKYLGVRLD KELRFAPHVE EVAAKAERTM AALSRLMPNT
     GGAKPYRRRM LVAVARSQIL YGAEIWGSRH LKSKSLEKLE RAQRTALLRV TSAYRTTSNE
     ALQVIAGTKP MALAIEERVE IRRMGPGARK AVEDRTRRKW QAAWQNAQNG AWTRKLIPDI
     GPWLDRKQGH TDFYLTQALT GHGCFGTYLH RIGKTADERC WFCGEDRDDP EHTLFLCERF
     DGERLEYMKK TLTWPNAEEF VEVMLSSEEN WASTSQLVRS GQVRSGQVRS GQVRSGQVRS
     GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS
     GQVRSGQVRS GQVRSGQVRS GQVRSGQVRS GQVRSREQKQ GVDATAQSTD DDKESIRREI
     LTQMDRPGTY AEVERVLNLE WPQDVYQATK VIKGSPLAAS RDWDLGIFLN EEDGGLDTTA
     MGRLFKERYP ELVEEEEEQD DISYIVQTTK FKSKVNTKYV WKIRIEKSMT NWEDKALNAE
     ILKKLRDIAD AMQVEGRVKV AIPIPPRASL DQLRKLAEIA FRNKGRELAI HVPQNFTVNG
     ISTANPNPKQ TKRRGVEKQT GALIVRKPGC EYIDLLKKVK KTLGNSENLK IYKALKTNKG
     DLLIVTENNE EALANARKTI VEEDNAISVT ISRPRGEGME LHIGNIEADI TAEQISEAVG
     KKMEVQPQEI VVKALRKGPA EMQVATIQVK KDLGESLLTQ RQIRIGLCLC TTTEKVELVR
     CYKCWGQGHI STKCSGPERK NLCRKCGKPG HKISDCRGNE YCLQCNEEGH RTGSNKCPVR
     RKEVRKLIRS ISTAKNGHPP QTEEKHMSQM ETEEVVPPDT PCVSTGLPSD SLRLRGGGGR
     GRPTGRPDII KVLQCNLNRS REAFQLLHGT VHDRQIDIAV VAEPNKKLSE MGPWTLDRRK
     DVAIRQFNKA EALRKHIGNG FVGVEYRGYA LYGCYISPNS TLDEFKQLLR ELEGHLNSSG
     EECIIVGDFN AKSPAWGSKK EDERGRILMD WIAQRDYTIQ NTGDEPTFVR GESVSNIDLT
     ITSNGLADKI KNWKVLPEEN LSDHRDIYFE ICKTKEENEA RTKRVRKSWK IDGEGLNIYR
     ELVRKEISGR GRHWSTGTLM QKIEEMCNSS FATCRGGHPA HKRPVYWWNR DIAEQRAKCL
     KARRTLGRGR KCRKTTSEQI QQLEDRYRMT KKELRGHIKK AKQTAWKELI EMIEEDPWGK
     GYKVAMGKFR KETPPSKEET KEAVKKLFPR RERTVWQKEP CQEKIEFSEQ ELRDAASRLR
     VKRAPGPDGI QAEIVKLVVE EATSDVLAVI NASAGKGEFP TRWKEAKLVL IPKTKQDSEG
     IRKFRPICLL DIMGKLFEHL IRSRLEKELD EKGGLADSQF GFRKGRSTLD AMEEVLKFAE
     TANRGTWGRK DLCAIVAIDV ENAFNSAPWK KIIEALEGKR INKALLALIQ DYLQDRGILV
     GEGEEYVEMT CGVPQGSVLG PTLWNVLYDA VLRLEMPVGV RTLAFADDLA VLVSSRNEEE
     MMALVNQTLQ KVAEWMEDTG LSVAAHKTEA TLLTGRRRPR EIKFSLKGED ISPQTSIKYL
     GVRLDKELRF APHVEEVAAK AERTMAALSR LMPNTGGAKP YRRRMLVAVA RSQILYGAEI
     WGSRHLKSKS LEKLERAQRT ALLRVTSAYR TTSNEALQVI AGTKPMALAI EERVEIRRMG
     PGARKAVEDR TRRKWQAAWQ NAQNGAWTRK LIPDIGPWLD RKQGHTDFYL TQALTGHGCF
     GTYLHRIGKT ADERCWFCGE DRDDPEHTLF LCERFDGERL EYMKKTLTWP NAEEFVEVML
     SSEENWASTS QLVRNIIRTK EREELRREGR LPT
//
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