ID A0A139WAH4_TRICA Unreviewed; 2128 AA.
AC A0A139WAH4;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN Name=AUGUSTUS-3.0.2_34914 {ECO:0000313|EMBL:KYB24913.1};
GN ORFNames=TcasGA2_TC034914 {ECO:0000313|EMBL:KYB24913.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB24913.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB24913.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB24913.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB24913.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB24913.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971388; KYB24913.1; -; Genomic_DNA.
DR EnsemblMetazoa; TC034914_001; TC034914_001; TC034914.
DR eggNOG; KOG0017; Eukaryota.
DR eggNOG; KOG1075; Eukaryota.
DR InParanoid; A0A139WAH4; -.
DR Proteomes; UP000007266; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR CDD; cd09077; R1-I-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 2.
DR SMART; SM00343; ZnF_C2HC; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 831..846
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 854..869
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 1310..1581
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 75..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1148..1200
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..161
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KYB24913.1"
FT NON_TER 2128
FT /evidence="ECO:0000313|EMBL:KYB24913.1"
SQ SEQUENCE 2128 AA; 240034 MW; 97E88AD4F068E8B0 CRC64;
MHSQHMRRLH IVQQESLRFS YCLAGIWICP YDEIFKPIQV RYDTDINYVS EFVQRMKIAH
RNAIANIEKS TQRVHDQFNR KEAPHSLQDG RPRSVVEMRS SDNDRFNIKA GVARKKGGGN
FILKDVPFFP GRGRARGPQN NQEPGHHKRR HRSSQRGARK NKGRLKPQDP PKRLGGTGTG
KPGVDPSYRR WSVACLLKTV IAARIQQPLL SAAGMNINSN PKEGEPTTIT EGRESRARNI
STTTTEEVSG RRANTGREAY MGIGNSSQSF DAGDRFLLLD VSGSWSSPKS TQGELPKTPK
RSLKTESPKK EEGRNLGYDT VSVFSSPEEI TDERQPKRKR EDTPKSTAQQ AGTNDEWKKL
CKAVEATHRE MERLTSEVSK NPNTKREINK SITVLKGLLH RVTVDNLGKL LKDNQTDTYV
GDDIKSEKSL QSNETGTQTE PSMVTIGTQT EDEPSCACQR DIALIRRWED QNTEEIRQAI
DQQVTGPELE NLFSRSWPEK AYTTTSTKSG SLFSSSTDSD LVIIGDTKDL TNKSVFRKVA
SRVPHLLALA KENKIKPGKV VHISCQSEIQ VEGDDLEKEH LGQNKRSTFL ATVEESTPSY
LEAATNLNKA SMKASSKLLA VAILVDDPKS RENIRKALEY SLKDLKATIY IPEDPTKNRS
SRRTANHERV AQEGIILTAN EGKTYADLLK EVKSGLSKSQ QEDNVIGCRQ TREGNLLLRI
RPNSKAATKI KEELANIQSA QRIRVVGQPT QNTLLIRGLD ALATNDDVEK AIERSGISLE
DTHIQLRPAW GNTKTAIIQS TKVTADALVQ SKELRIGLTL CQIRPRQPEN KCFRCWETGH
RADTCKGPDR SKLCLKCGKN DHKAAECKNE MFCPICNLNA NRSRRAHDIL HKTASETNSD
IVLLSEPNLK VVDNPRYLHD IRKDTAINIL SKHVQLKCSG SGSGFTWIST SVVTVYSCYI
SPNSTIGEFI NVLESLTTSM QTQSDPVIVT GDFNAKSTEW GMPYSDRRGS LLADWIAQHD
LTAVNKHDEY TFQRGRAQSI IDLTLVPTYL VHKLSNWRTL DAESLSDHKY IAFTWDDNAG
TTCQTSGYTG WNLKRLDKDK LLSKLREATC ESTPASLNKI LQRACNAAMP KKRCFRNRRP
VYWWNEKIAN LRKNALKFRR TITRLRSKRQ VSVMLIDGTT SKLKQAQKML RDEIQKAKSE
KWKELCLSLE DDLWGNGYQT VMKRTGQACP FKLPREQLNN IVAILFPLHA DVDWIKENCK
PIPDFTHDEL RDAARRLKSG KAPGPDGVPG EIIKIMVEER PDTLLEIFNR CAKDSTFPDC
WKIARLILLP KPGKLNRTAN AFRPICILDA SGKLYEYLLY KRLDDEIEQR GGLSPFQFGF
RKGVSTVHAI DEVIRTAEQE KLPSYRHRKT CLMITFDVQN AFNSASWQII LEELKQKGIS
PSLINTIRDY LNNRKIITDY GDTVKVNSGV PQGSVLAALL WNVMYDSVLR IATSENVKLI
GYADDLAVII TCKQIDGLEE TANHVVAQIA DWMETKRLKL APEKTECILL RCKRKPPAVK
INVLGTEISP KSSIKYLGVW IDQNCGFKQH IQQTAIKVEK TITALSSVMP NIGGPSSSKR
RMLSSVAHSA MLYGAPIWHN AMTIESYKKI LFSLQRRLAI RIASAYRTAP TDAIMVISGI
PPVHLQATER KDIFYGMSRS DARDKLINKW QREWTGRKCW TSKLIPDLRV WLQRDHGTLN
YYLTQFLTGH GNFRSYLSGI QRCPDDECIY CGKRDSAEHI LYCPRWKDFR DDVGVHLSRE
NIIGVMLESP ENWAKISGLL TEILKQKDKE ELGERCAIMA FADDLILIAD RDQDVPAMFD
DVSTFLERRG MSVNPAKCRA LIAGAVSGRS VVRTGSSYNI HNTPIPNVDA LDAFKYLGLE
FGHNGVERPT IHNLSVWLNN LRRAPLKPDQ KCLFIRQYVI PRLLYGMQNP QVTSRVLREA
DRLIRRHLKT YCHLNVHTPD SLIHASVSDG GLGIMELRKA IPRIFLGRLV KLLNKNKNSY
LSSVLQSNRV RTLMGKLSTM AGEVPESTFW RNQIASGPLS KSLEQRAKDS ASRLWISEKP
SGWSGRDHVR AVQLRTGNLP TKAIPSVP
//