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Database: UniProt
Entry: A0A139WAH4_TRICA
LinkDB: A0A139WAH4_TRICA
Original site: A0A139WAH4_TRICA 
ID   A0A139WAH4_TRICA        Unreviewed;      2128 AA.
AC   A0A139WAH4;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   13-SEP-2023, entry version 25.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   Name=AUGUSTUS-3.0.2_34914 {ECO:0000313|EMBL:KYB24913.1};
GN   ORFNames=TcasGA2_TC034914 {ECO:0000313|EMBL:KYB24913.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB24913.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:KYB24913.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB24913.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA   Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA   Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA   Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA   Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA   Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA   Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA   Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA   Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA   Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA   Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA   Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA   Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA   Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA   Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA   Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA   Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA   Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA   Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA   Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA   Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA   Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA   Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA   Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA   Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA   Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA   Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA   Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA   Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA   Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA   Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA   Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA   Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA   Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:KYB24913.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB24913.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT   for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
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DR   EMBL; KQ971388; KYB24913.1; -; Genomic_DNA.
DR   EnsemblMetazoa; TC034914_001; TC034914_001; TC034914.
DR   eggNOG; KOG0017; Eukaryota.
DR   eggNOG; KOG1075; Eukaryota.
DR   InParanoid; A0A139WAH4; -.
DR   Proteomes; UP000007266; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR   CDD; cd09077; R1-I-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 2.
DR   SMART; SM00343; ZnF_C2HC; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS50158; ZF_CCHC; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          831..846
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          854..869
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          1310..1581
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          75..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1148..1200
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        145..161
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..316
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..345
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KYB24913.1"
FT   NON_TER         2128
FT                   /evidence="ECO:0000313|EMBL:KYB24913.1"
SQ   SEQUENCE   2128 AA;  240034 MW;  97E88AD4F068E8B0 CRC64;
     MHSQHMRRLH IVQQESLRFS YCLAGIWICP YDEIFKPIQV RYDTDINYVS EFVQRMKIAH
     RNAIANIEKS TQRVHDQFNR KEAPHSLQDG RPRSVVEMRS SDNDRFNIKA GVARKKGGGN
     FILKDVPFFP GRGRARGPQN NQEPGHHKRR HRSSQRGARK NKGRLKPQDP PKRLGGTGTG
     KPGVDPSYRR WSVACLLKTV IAARIQQPLL SAAGMNINSN PKEGEPTTIT EGRESRARNI
     STTTTEEVSG RRANTGREAY MGIGNSSQSF DAGDRFLLLD VSGSWSSPKS TQGELPKTPK
     RSLKTESPKK EEGRNLGYDT VSVFSSPEEI TDERQPKRKR EDTPKSTAQQ AGTNDEWKKL
     CKAVEATHRE MERLTSEVSK NPNTKREINK SITVLKGLLH RVTVDNLGKL LKDNQTDTYV
     GDDIKSEKSL QSNETGTQTE PSMVTIGTQT EDEPSCACQR DIALIRRWED QNTEEIRQAI
     DQQVTGPELE NLFSRSWPEK AYTTTSTKSG SLFSSSTDSD LVIIGDTKDL TNKSVFRKVA
     SRVPHLLALA KENKIKPGKV VHISCQSEIQ VEGDDLEKEH LGQNKRSTFL ATVEESTPSY
     LEAATNLNKA SMKASSKLLA VAILVDDPKS RENIRKALEY SLKDLKATIY IPEDPTKNRS
     SRRTANHERV AQEGIILTAN EGKTYADLLK EVKSGLSKSQ QEDNVIGCRQ TREGNLLLRI
     RPNSKAATKI KEELANIQSA QRIRVVGQPT QNTLLIRGLD ALATNDDVEK AIERSGISLE
     DTHIQLRPAW GNTKTAIIQS TKVTADALVQ SKELRIGLTL CQIRPRQPEN KCFRCWETGH
     RADTCKGPDR SKLCLKCGKN DHKAAECKNE MFCPICNLNA NRSRRAHDIL HKTASETNSD
     IVLLSEPNLK VVDNPRYLHD IRKDTAINIL SKHVQLKCSG SGSGFTWIST SVVTVYSCYI
     SPNSTIGEFI NVLESLTTSM QTQSDPVIVT GDFNAKSTEW GMPYSDRRGS LLADWIAQHD
     LTAVNKHDEY TFQRGRAQSI IDLTLVPTYL VHKLSNWRTL DAESLSDHKY IAFTWDDNAG
     TTCQTSGYTG WNLKRLDKDK LLSKLREATC ESTPASLNKI LQRACNAAMP KKRCFRNRRP
     VYWWNEKIAN LRKNALKFRR TITRLRSKRQ VSVMLIDGTT SKLKQAQKML RDEIQKAKSE
     KWKELCLSLE DDLWGNGYQT VMKRTGQACP FKLPREQLNN IVAILFPLHA DVDWIKENCK
     PIPDFTHDEL RDAARRLKSG KAPGPDGVPG EIIKIMVEER PDTLLEIFNR CAKDSTFPDC
     WKIARLILLP KPGKLNRTAN AFRPICILDA SGKLYEYLLY KRLDDEIEQR GGLSPFQFGF
     RKGVSTVHAI DEVIRTAEQE KLPSYRHRKT CLMITFDVQN AFNSASWQII LEELKQKGIS
     PSLINTIRDY LNNRKIITDY GDTVKVNSGV PQGSVLAALL WNVMYDSVLR IATSENVKLI
     GYADDLAVII TCKQIDGLEE TANHVVAQIA DWMETKRLKL APEKTECILL RCKRKPPAVK
     INVLGTEISP KSSIKYLGVW IDQNCGFKQH IQQTAIKVEK TITALSSVMP NIGGPSSSKR
     RMLSSVAHSA MLYGAPIWHN AMTIESYKKI LFSLQRRLAI RIASAYRTAP TDAIMVISGI
     PPVHLQATER KDIFYGMSRS DARDKLINKW QREWTGRKCW TSKLIPDLRV WLQRDHGTLN
     YYLTQFLTGH GNFRSYLSGI QRCPDDECIY CGKRDSAEHI LYCPRWKDFR DDVGVHLSRE
     NIIGVMLESP ENWAKISGLL TEILKQKDKE ELGERCAIMA FADDLILIAD RDQDVPAMFD
     DVSTFLERRG MSVNPAKCRA LIAGAVSGRS VVRTGSSYNI HNTPIPNVDA LDAFKYLGLE
     FGHNGVERPT IHNLSVWLNN LRRAPLKPDQ KCLFIRQYVI PRLLYGMQNP QVTSRVLREA
     DRLIRRHLKT YCHLNVHTPD SLIHASVSDG GLGIMELRKA IPRIFLGRLV KLLNKNKNSY
     LSSVLQSNRV RTLMGKLSTM AGEVPESTFW RNQIASGPLS KSLEQRAKDS ASRLWISEKP
     SGWSGRDHVR AVQLRTGNLP TKAIPSVP
//
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