ID A0A139WGD1_TRICA Unreviewed; 1576 AA.
AC A0A139WGD1;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H4-like Protein {ECO:0008006|Google:ProtNLM};
GN Name=AUGUSTUS-3.0.2_33375 {ECO:0000313|EMBL:KYB27050.1};
GN ORFNames=TcasGA2_TC033375 {ECO:0000313|EMBL:KYB27050.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB27050.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB27050.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB27050.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB27050.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB27050.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971345; KYB27050.1; -; Genomic_DNA.
DR EnsemblMetazoa; TC033375_001; TC033375_001; TC033375.
DR Proteomes; UP000007266; Linkage group 6.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF108; VWA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 2.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 2.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 1..124
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 261..478
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 796..905
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1105..1322
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1576 AA; 179990 MW; E8FD7FE05C9ECBB5 CRC64;
MESSGVVSPQ IYSMHIETTI NNRFAKTLIT SKVKNTDNKA KEAIFSVILP ENAFISEFEM
EIDGKVYKAY VKEKAEAKAI YNQAVSRGFS AGYVELDVRD SKKFTVSVNI EPSSETIFRL
TYEELLQRQN GQYELIINVH PGQIVDDLCV EVKIDETRPL AFVKTPSLRT GNEISDDKPE
LDPCAKTEMI NANSAKVRFN PDKEQQKKYA ELLGSKDQGL AGQFVVQYDV ERDPKGGEVL
LRDGYFVHFF APSGLQTFPK HVVFVLDHSG SMEGRKYEQL MQAMDKILSD LNPDDLFHIV
RFSENVSVWN FEKNKFDQVS FLQKPEYRNL DSFLAEFNLG DAAQVTEGNI KKAKKIKDHD
VDMGCTNIIG GLVVGLYLVR RTLQKFYEKN VETKHQPMII FLTDGLPNEG ISNPDKITKI
VTKINQGTNR AAIFSLSFGE DADKNFLKKL SAQNLGFSRH IYEAADAALQ LQNFYRTVSS
PLLRDVRFKY VDKVSEVTRI DFPIFFLGSE FVIAGRCGDT RPLRHVEAFC TNGCIEFETD
ETESDVSLER LWAYLTVKQL LDEAETSENR TELTKKALNL ALRYSFVTSV TSLVVVKPQQ
NDVLDYENEA LELPDCCGEM LEACALLERH ECRMQRLKTS PFHRLYRHCR ASVFVAPKLP
NLTSEIRKVF TDLKYKDKIT HLKNWVNTTQ PHLPQINDTQ ARLFLQCCDF NEEVAKNLVD
SYFTIRTLCP EFFTGRDVSD PSFRSKLGVV FFTFVAEKTQ GYICVKLRDI DSNVFDFTEL
IKCFDVVCSL QLSKGEIVYD YCVVLDMIGL SSKHLDKVEP AVLKKFLFYL QEAFPLNIKE
IHCYVRPLDD DDDDIVANLL ALIKPFVKEE IMSKIRFYNN VGDLLNSVPK KCVSAANGGT
LDVEKLHLKL RREIFKKIAF FKEEEKQAVS KGFSAAFVEL DVRDSKKFTV SVNIEPSSET
IFRLTYEELL QRQNGQYELI INVHPGQIVH DLCVEVKIDE TRPLTFVKTP SLRTGNEISD
DKPELDPCAK TEMINANSAK VKFNPDKEQQ KKYAELLGSK DEGLAGQFVV QYDVERDPKG
GEVLLRDGYF VHFFAPSGLQ TLPKHVVFVL DYSASMEGRK HEQLMQAMDK ILSDLNPDDL
FHIVRFSVIV SVWNFEKNRF DQIKFAQKPE YENLDSFLAE FNLGDAAQVS EDNIKKAKEI
KDHDVDMDCT NIIGGLVVGL YLVRQTLEKF YEKNIETKHQ PMIIFLTDGL PNVGLIIRDE
ITDVVTKINQ GTNRAAIFSL SFGEDADKNF LKKLSAQNLG FSRHIYEAAD AALQLQNFYR
TVSSPLLRDV RFKYVDKVSE MTRIDFPIFF LGSEFVIAGR CGDTRPLRHV EAFCTNGCIE
FETDETESDV SLERLWAYLT VKQLLDEAET SENRTKLTKK ALVLSLKYSF VTSVTSLVVV
KPQGDDFVVG AHDSRPRLKK QGLKRSPLRR FYRHCRAHVF VAPELPNLTS EIRKVCTCLK
YKEKITQFKT WVNTTQPHLP QINDTQAHFF LQCCDYDEEI AKNLVDSYFT IRTLCPEFFT
GRDVSDPSFR SKLGVV
//
