ID A0A139WK62_TRICA Unreviewed; 2024 AA.
AC A0A139WK62;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE SubName: Full=Otoferlin-like Protein {ECO:0000313|EMBL:KYB28306.1};
GN Name=AUGUSTUS-3.0.2_32643 {ECO:0000313|EMBL:KYB28306.1};
GN ORFNames=TcasGA2_TC032643 {ECO:0000313|EMBL:KYB28306.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB28306.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB28306.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB28306.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB28306.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB28306.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971331; KYB28306.1; -; Genomic_DNA.
DR RefSeq; XP_015834065.1; XM_015978579.1.
DR EnsemblMetazoa; TC032643_002; TC032643_002; TC032643.
DR GeneID; 657013; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000007266; Linkage group 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 5.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1991..2011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 269..389
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 427..562
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 962..1095
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1145..1268
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1505..1623
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1744..1892
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 159..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2024 AA; 229789 MW; 3AD6DA5C78055E5A CRC64;
MSLSVKLKQF KIAKCKGEKL AKVEFRGVSH LTKILDDSGG DIIIVDQIFD WPVARPIEEN
ELLLVELYSR NRLFSDKLLG SYTLVLQRAV RDGRVSVADS LVDPNSKPIL ATVQFEVLYT
LPDESTASFT GSNAYDMLDD EQQMLIDIEQ NIANIERNLT RDKTPKLKHA NSLATPEKSP
TPVDRKRSST LKSVRSLIRF GKQRPPKDSD NEEEVSLIHA AESGRTSRQA SESESAPVSR
AGSQSSVCSN PDNPADVSLM ERNRKTTKLK TDMKTTVQSV LKAQDFQVCL TIIEARQLAG
LNMDPVVCIQ VGDQKKYTSV KESTNCPYYN EYFVFDFHMP PIMLFDKIIT LSVLHSRKLL
RPGTVVGTFK IDVKTVYDAP DHQFYHKWAL LTDPDDIAGG PKGYLKCDIS VIGKGDTVKV
PPKSEKDEDD IEANLLLPDG VPIDRQRARF IVKIYRADGL PKMNSSLMAN VKKAFTGELS
DLVDPYVQVS FAGLTGKTSV KKHSYAPVWN EQLVFTEMFP PLCQRIKIQL RDNDPVKPTV
IGTHFIDLKT ISNDGEKGFL PTFGPSFIHL YGSTRDYSLI DEHSSLNTGL GEGVSYRARL
LVAIRTEITD SIDLAPSAVE IEPTIPVNEA SYAKNEEFFL FATILDASMI DKKLGDKPVY
FEISIGNAGN AIDGHNESTR EHYDSDSDEL EAVSTDSGSW QSTTTPTKPM THDKIYYFLP
YWDNKPCMHI RSVWPDYRRR MYNSNIISKI SEKLEDGLSE VNSLMDSDDP EIETRLKQVL
EDLSIGCAKY VTISQASMTG PGTGKTKLDK EHLKLCQREI EHIGSAARNL RALVTKSSFR
ERYKTAQTYL TKLKFLTEDP QHALPDVFLW IISGGKRQAY QRISARDIIY SIVDEESGRD
CGKVQTMFLK LPGKRSTGPS GWSIPAKLQI YLWLGMLKHK KNFINGIPKG YETTHEIRNV
ERPRALPPSI IHYVEKHIFQ LRAHIYQARS LIGSDASGLS DPFARVIAGE FSKTTQVIDE
TLSPTWDELL IFGEILIYGT AEEIKQDPPS IIIEIFDQDK VGKSEFIGRA LAKAHVKLRE
EAYTKPKFPP SLEWFDITRG SDHAGELLAA FELLELPNDV DGGTLPPLPA PKDIPIYKDT
DLKDLVPMLP VPRGIRPTLA RYRIEVLFWG LRDLKRIHLL TVDKPRVDIE CSGHILYSSI
IQNAKKNPNF SNPVKFLDLD LPEQELYRPP LTIRAVDCRS FGRYTLVGTH MINSIHKYMY
SPLTKKDREE DRKRSLNQPK PDILPQQSSP TNLTFPENDK EKSPLLPKDI SISIGYGTQQ
SVAKAKAETG KKRKPSLDED VDDEEGSRDW WTKYFASIER MIDESKEAKK LLSQQNGNLQ
ILVDEDGQQS GNTSDKSPGD GKRRFGFKTA ATASRFAARI SPKSVRKRSK YKPALCKIYP
TELEAVPEFG EFKEWLHTFE LYRGKKTGDE SEDDSRVVGY FKGAIKVYKW PLPKDLEDHT
IMGLDPQFGF FQGLPSNDPI RVLVRVYVVK ANDLHPMDLN GKADPYVVIQ LGSKRISDKD
NYISKQLNPV FGKCFEIEAT FPQDSLLTIQ IYDWDLVGSD DMVGETKIDL ENRFYSRHRA
TCGLPEKYEE QGYNAWRDAM KPTQILAKLC KDAKVEPPVY ADGQIKIGRQ IFTLQSEDFD
FFKTKESEEH MALAVLHRWH EFPKVGCHLI PEHVETRPLY NPDKPGIEQG KLEMWVDMFP
MDMPLPGPPL DISPRKPKSY ELRVIIWNTD DVVLEDDAFF TGEKMSDIYV KGWLKGPEDC
QCTDIHYRSL TGEGNFNWRF IFPFDYMVAE QKIVISRKES LFSWDETECK IPARLELQVW
DADHFSADDF LGAITLDLNR FPRGAKSSKL CTLDMLKSDG SVPVVNIFKQ KRVKGWWPFF
IKKDNEEMEL TGKVEAEIHL LSREEADKNP VGLGRGEPDP LEKPNRPDSS FMWFMNPLKS
IRYIIWHNYK WTILKLFIII GLAIIILLFF YSIPGYTVKK MLGA
//
