ID A0A139WKL7_TRICA Unreviewed; 2156 AA.
AC A0A139WKL7;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ankyrin-2-like Protein {ECO:0000313|EMBL:KYB28367.1};
GN Name=AUGUSTUS-3.0.2_32574 {ECO:0000313|EMBL:KYB28367.1};
GN ORFNames=TcasGA2_TC032574 {ECO:0000313|EMBL:KYB28367.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB28367.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB28367.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB28367.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB28367.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB28367.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; KQ971328; KYB28367.1; -; Genomic_DNA.
DR STRING; 7070.A0A139WKL7; -.
DR EnsemblMetazoa; TC032574_003; TC032574_003; TC032574.
DR InParanoid; A0A139WKL7; -.
DR OMA; WISRRCA; -.
DR Proteomes; UP000007266; Linkage group 3.
DR GO; GO:0043194; C:axon initial segment; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF165; IPT_TIG DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00023; Ank; 4.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2136..2154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 72..104
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 105..137
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 138..170
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 171..194
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 233..265
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 266..298
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 299..331
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 332..364
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 365..397
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 398..430
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 431..463
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 464..496
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 497..529
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 530..562
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 563..595
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 596..628
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 629..661
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 662..694
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 695..727
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 728..760
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 761..793
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1000..1157
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1159..1306
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1492..1569
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2063..2124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1817..1844
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2076..2090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2156 AA; 236529 MW; B30966952F39E627 CRC64;
MALGNGSTPN GGVTQEKAPV VNGTNMETLP RAGKQTDPNT AFLRAARANQ LDKIQEYLDS
GTVRDINTSN ANGLNALHLA AKDGHVEIAR ELLKRGAIVD AATKKGNTAL HIASLAGQEE
IVRLLVQHGA SLNVQSQNGF TPLYMAAQEN HDGVVKYLLS KGANQTLATE DGFTPLAVAM
QQGHDKVVAV LLENDTRGKV RLPALHIAAK KDDVKAAALL LQNEHNPDVT SKSGFTPLHI
AAHYGNDKVA SLLYDKGADV NYAAKHNITP LHVASKWGKN NMVTLLVAKG ADIQAKTRDG
LTPLHCAARS GHDQVVDMLL ENGAPMHAKT KNGLAPLHMA AQGEHVDAAR ILLYHGAPVD
EVTVDYLTAL HVAAHCGHVR VAKLLLDRGA DPNARALNGF TPLHIACKKN RIKMVELLLK
HGASIGATTE SGLTPLHVAS FMGCMNIVIY LLQHDASPDI PTVRGETPLH LAARANQTDI
IRILLRNGAA VDAKAREEQT PLHVASRLGN VDIVMLLLQH GAQPHATTKD LYTPLHIAAK
EGQEEVASVL LDHGADLTAT TKKGFTPLHL AAKYGHLNVA RLLLQRDAPA DAQGKNGVTP
LHVAAHYDHQ PVALLLLDKG ASPHAVAKNG HTPLHIAARK NQMDIATTLL EYGAQADAES
KAGFTPLHLS AQEGHSDMSS LLLEHQADPN HTAKNGLTPL HLCAQEDRVA VAQLLLRAGA
QKDVQTKAGY TPLHVACHHG HVNMVRLLIE QGAEVNPVTS AGYTPLHQAA QQGHVLVISL
LLKNKANPNA ITQNGQTALG IANKLGYISV VEELKVVTET NITTTTTVNI EEKYKVMAPE
AMQETFMSDS EDEGGGVDEP PVAYGRPTHA QHVYLPFYQG HMTYTRDDPI LGDQQQYKYM
TVDDMKSLGD DSMRMDVTRD EKSDYRNSMA PSHISNELII NPAHVKEYYT SNTFSAPDNV
DINRQPITVG LCRQEWSNLE YSLHLLGPKS QGSGLCRESF LVSFLVDARG GAMRGCRHSG
VRVIVPPRCA SSPTRITCRY IRPQKTPNPP PLMEGEALAS RLLELGPVGA KFLGPVIIEV
PHFASLRGKQ REIVVLRSDN GETWKEHTLE ANEEAIQDVL NHSFDGEELS QIEDLHTNRI
TRILTNDFPH YFAVVSRIRQ EIHAIGPDGG TVSSSAVPLV QAVFPPNALT KKIRVGLQAQ
AIEPELVSKL LGHGVAVSPI VTVEPRRRKF HKAITLSMPA PRAHSQGMIN QYSGSAPTLR
LLCSITGGQN KAVWEDVTGS TPLTFVKDCV SFTTTVSARF WLMDCRNVSD AARMATDLYN
QAAHVPFMAK FVVFAKRVSL FESRIRVFCM TDDKEDKTLE HQEHFVEIAK SRDIEVLENK
DVFMEFAGNL VPVLQSGEQP RLGFKAFREN RSAFTMRLRD PDEEPVGRIV FMSDSKVAKG
EPNQTPLCTL NLVLPKEILP DRDSQSDLLS LDVDNSFLHH GGISKPDTIH RADFRISDIC
NLLDEDWVKL AAELDITPTD ISLIKEEYPN NNPQQAMIMF RLWLRQKANK ATGNKLELAL
KKIGRPDIVA KCICNVELVT DDMEKALAKV RLDQSGFDTL KDELGSSRDT SLKRNASLSK
YSKGSQDELD KSDRSNDFHN QNSTDKDLTD TTSDHLSMKK DHKPENQLDN RTTSPNANHE
VLEEITHQLT NLQTTPKLKV DTNANTPPPS PAEFHFDKEA NFTQGVNEEI ITSTPLKTTN
QCDDFVDPIA VLKKNVSDTL TFLHQERNDF LPEDDIIIPS RKDDHISRKI NLDSINLKNQ
KKSDLKNVVE SEVDDVIKKA ECVVNELTEK TDSLLDDCKN ATEDSLDNLD SLKDDSISNA
QEAFRFLENE ISSPPTPVKD HDESNKFVTF SEEFDKSNRN NSAIPVAKPR KVEKEKDIDL
LFSLNGRESV SPTDDDLLSK IPIKGGKVKT IKKHSKDPLK EFVKLAQEVN WDDSDDITSD
PIVKTTPTRI TTTEPVVEKT KSKIPVLHTE SLSPTEITER YEVSPKSKIP ILRTETTRIT
SPETTTFVER TIISPTQVVE TTVVSPGSKI STKSSTLDSD SDEDSPRSPP LKGILKKTVG
SSSGSDVALH EEGAELSESE TASKNSLETW HVLSPLVWSV VALATSMIVL ALLAQY
//
