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Database: UniProt
Entry: A0A139WLU9_TRICA
LinkDB: A0A139WLU9_TRICA
Original site: A0A139WLU9_TRICA 
ID   A0A139WLU9_TRICA        Unreviewed;      1094 AA.
AC   A0A139WLU9;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   03-JUL-2019, entry version 19.
DE   SubName: Full=Tyrosine-protein kinase-like otk {ECO:0000313|EMBL:KYB28864.1};
GN   ORFNames=TcasGA2_TC032332 {ECO:0000313|EMBL:KYB28864.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB28864.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:KYB28864.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB28864.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:KYB28864.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB28864.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000256|SAAS:SAAS00602168}.
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DR   EMBL; KQ971319; KYB28864.1; -; Genomic_DNA.
DR   RefSeq; XP_972111.1; XM_967018.3.
DR   STRING; 7070.TC003353-PA; -.
DR   EnsemblMetazoa; TC032332_001; TC032332_001; TC032332.
DR   GeneID; 660815; -.
DR   KEGG; tca:660815; -.
DR   KO; K05127; -.
DR   OrthoDB; 530072at2759; -.
DR   Proteomes; UP000007266; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00409; IG; 7.
DR   SMART; SM00408; IGc2; 7.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 7.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 6.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000313|EMBL:KYB28864.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Repeat {ECO:0000256|SAAS:SAAS00295312};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:KYB28864.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1094       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007300180.
FT   TRANSMEM    703    724       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       23    113       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      118    206       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      317    401       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      408    489       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      501    593       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      598    685       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      811   1091       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      745    801       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A139WLU9}.
FT   COMPBIAS    783    800       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A139WLU9}.
SQ   SEQUENCE   1094 AA;  122333 MW;  0F77CB9AB5950102 CRC64;
     MPGFNLIFFL LVLVHVVIGK EDPYFSESPR NVDVVQGKSV TLPCKVTPGI GMTYYWELNG
     SKIANTTRRH QQGSNLHITR VDRERDSGQF TCIAEDSTSS LAGSIRSSEA SLNIQWIDEV
     SVQLQEPESA SFISRGSDVT LRCHTDASGD VHYEWFRNSD RLLKSDKIEI KKKRLHIKNV
     GPSDNGVYRC LANNTAGARY STTNFALAVA GEETALIQVV PRDQLVPQGG TAYFDCQYQQ
     AEVTEWYFKK DTRPLENGKK FVIHSNGTLQ INDVQGKDQG FYSCVGIRSE STEIPQSYIA
     ELKLAYLSEF TVNSFEPPLS ENSNQVVAPE GGLFQLTCLE PDSLPPAKKW WLNTGGHTVS
     DSGEVRVDDG RLIIEKVRMD HAGNYTCVAE NMAGKTEKII ELVVLNKPVV TAQPLSVTVD
     ENEPSMLTCD YEPKNHFTIV KWRKDGKSLR HDFGENSLDR QRIKIFKHNA SLVIRETESH
     DRGEYVCEVL AKGFEPVLSE PATISVIEKL KFVPPPVNKK LELGSVAKVH CKAQGTPPPI
     ITWEKLGESF DNSRIISMNG TLVFNGVLNE DKGKYTCVAT NSQGVINVTI NIDVVVAPKF
     SVEPKNPTEV TEGQSVTIDC VVEGDPKPTI HWDKNLKMND FDHSRFTVLE NGTLFISEVH
     REDENKYGCT AGNSAGLNRQ EVQLIVHSRD GYHPDGDSTV TKAVLITMSV AGAYIVLVIG
     LMVWCRYRRR SRKLPVTDAA KTENGEVDHT ELKDGANGHC SGTSKVATNG LEALKEGQKS
     DGAETTHSQS SNQSKKSKSN YDKLALSRTH LKEMKLIGRG EFGEVMVAKM SKSALLSEKR
     NSQATTPPIE DKELPVLVKA LSHTKDENSL SEFKREIDMF LKLSHENITK IYGLCREAEP
     HYMILEHTDW GDLKQFLVAT QKGSPPPLTP VQCVAIVHQL CQGLDHLATS RLIHRDLAAR
     NCLVTSTLKA KVGLPRLTRD PYSQEYCKHV NHIIPLRWLP YEAVYEDEYS TKSDVYSFAV
     VIWEIFNQGE LPFPKMNDTS FLNKLKEKKL EWKPHSSTPE SLQKLQASCW DSNPQNRPTF
     SELAKEIEEV LKSM
//
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