ID A0A139WM47_TRICA Unreviewed; 1450 AA.
AC A0A139WM47;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Potassium channel subfamily T member 1-like Protein {ECO:0000313|EMBL:KYB29020.1};
GN Name=AUGUSTUS-3.0.2_32248 {ECO:0000313|EMBL:KYB29020.1};
GN ORFNames=TcasGA2_TC032248 {ECO:0000313|EMBL:KYB29020.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB29020.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB29020.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29020.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB29020.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29020.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KQ971314; KYB29020.1; -; Genomic_DNA.
DR STRING; 7070.A0A139WM47; -.
DR EnsemblMetazoa; TC032248_001; TC032248_001; TC032248.
DR eggNOG; KOG3193; Eukaryota.
DR InParanoid; A0A139WM47; -.
DR OMA; SADASHY; -.
DR Proteomes; UP000007266; Linkage group 2.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005228; F:intracellular sodium-activated potassium channel activity; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF10; SLOWPOKE 2, ISOFORM D; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:KYB29020.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 97..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 277..339
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 501..594
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 693..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 162933 MW; 3B75C98C8F73691F CRC64;
MSMYFFRLHN LRRAEEDKKK KQQSRRRGKV VGCHRLTTNA LTLAPSRLFE RPPLTPSDSL
DEVALQIPRV RVEYYVNENT FKERLQLYFI KNQRSSLRIR IANLFLKLLS CILYIIRVVT
DLDPTYAACY GCTPGDKSEY IISANLTEEK FQENPIINWD AILWVNRPLE LWIVQVVLAM
ISLTEALLLA YLGYKGNIWQ QLLSFHFILE IVNTIPFTLT LFYPPLRNLF IPVFLNCWLA
KHALENMFND LHRAMQKSQS ALSQQLTILS ATLVCLVFTS VCGIQHFQRA GHRHLNLFQA
TYYVVVTFST VGYGDFVPDI WPSQLYMVIM ICVALIVLPT QFEQLAFTWM ERQKLGGSYS
SHRAQSEKHV VVCSTTLHAD TIMDFLNEFY AHPLLQDYYV VLLSPMELDT TMRMILQVPI
WAQRVIYIQG SCLKDGDLAR ARMNEAEACF VLAARNYADK TAADEHTILR SWAVKDFAPN
VAQYVQIFRP ENKIHVKFAE YVVCEDEFKY ALLANNCTCP GASTLVTLLL HTSRGQEGQQ
SQEEWHRLYG RCSGNEIYHI TLGDSRFFGE YEGKSFTYAS FHSHRKYGVA LVGVRPAELP
EFYEDTILLN PGPRHIMKKS DTCYYMSITK EENSSFTVAN QPQGNNNNTS TEPVIVTAEE
KSQAPATKDG TGSPQLILQV PTCVTTFPDN AGLSDSRQCL KESSPGSTTI DVSITGNHLD
IPRSGDNPNL LSPEMINQRR NSRRPSILPV PDMFTSSSLN IPQDVADEGD ESEDELEDDV
PWRSPSEKIA SSLTDDSGDS ERPAWHDECA RIVKGFPPVS PYIGVSPTLC YLLKEKKPLC
CLQLAQVCEH CSYRNARDYQ WQNKTIILAA DYASNGIYNF IIPLRAHFRS KTSLNPIILL
LERRPDIAFL DAISYFPLVY WMLGTIDCLD DLLRAGITLA ENVVVVNKEL SNSAEEDSLA
DCNTIVAVQT MFKFFPSIKS ITELSQSSNM RFMQFRAHDK YALHLSKMEK REKERGSHIS
YMFRLPFAAG SVFSASMLDT LLYQAFVKDY VITFVRLLLG IDQAPGSGFL TSMKITKDDM
WIRTYGRLYQ KLCSTTCEIP IGIYRTQDTS LSDSSHLDEE LGPDRVGVTY RPKEGTNCLG
CTDRRNSMFS INMADEAKDN HEQQIERAEI ANLVRSRMES LNLPTIDYND VSEKRNSLSY
VIINPSCDLK LEEGDIIYLV RPSPFSAQKT FERHNSRRKS NISFCSQTLI QQMAAASQAG
SRRGSGLGLT GYQSPRPPPL STTKSNSLSL PDSPTVAGYQ RGRSNSLRVI DDILLRRSNS
LRQGLTSVGS GRRKSSLEDI GLSHFSTNYN NPIKIALNGS IGLEVTPPEE NSPPVISSNT
AMVVNAAAHT GSTISLAQSG LPSSSSSLPQ PLNLGINVPT NFGEAAPVQQ AALPPPAAPT
DPQHLQGTIV
//
