ID A0A139WP66_TRICA Unreviewed; 1218 AA.
AC A0A139WP66;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-3-like Protein {ECO:0000313|EMBL:KYB29565.1};
GN Name=AUGUSTUS-3.0.2_01887 {ECO:0000313|EMBL:KYB29565.1};
GN ORFNames=TcasGA2_TC001887 {ECO:0000313|EMBL:KYB29565.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB29565.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB29565.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29565.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB29565.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29565.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971307; KYB29565.1; -; Genomic_DNA.
DR RefSeq; XP_015834582.1; XM_015979096.1.
DR AlphaFoldDB; A0A139WP66; -.
DR STRING; 7070.A0A139WP66; -.
DR EnsemblMetazoa; TC001887_002; TC001887_002; TC001887.
DR GeneID; 658471; -.
DR InParanoid; A0A139WP66; -.
DR OMA; PLFANNI; -.
DR OrthoDB; 2971287at2759; -.
DR Proteomes; UP000007266; Linkage group 1.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1218
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007300366"
FT DOMAIN 263..442
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1218 AA; 139356 MW; EFCAB327CA83DAE1 CRC64;
MVCASLVRRR TFKKLFYVVV VFLVRICPAF MDQGEDIPHN EVRNWALKFG VDLWEYGKMS
TRLKELQRKY HDENIKVARK DGLLLIRDMA KEVQNMMSFK IEAVRRITES AEQAALTPQT
DNGQPFRYYN AKRLNSFGPD GRPVEGTREM MLTPNPHFDH LPVNTSLSTV LIPPNVEEYD
PEVINAIQWS EHLDPLFIHN YEDDPSLSWQ FFGSGTGFLR RYPGIAWPPV DMSTVWQRPR
SSRNVYDFRS SAWYVSAATS PKDIVILIDN SGSMSGHKSN LARATTESIL NTLGDNDFVN
VFKFSDITEE TVPCFKDMLV QANNENVRWL KESLSTFKSE NIANFTAALV TGFEILHKYN
RTGQGCQCNQ AIMLITDGPP SSYQEIFKMY NFPHYPVRIF TYLVGKDSSS AHEMRWMACA
NKGYYTRIEN FDEINQKVLH YIEVLARPMV MYQTDHPIQW TPAYVGGRAD SFLNDKVGQL
ITTVTTPVFD RRNHTVRVAN LLGVVGTDVS IDQIKKLVPP YKLGVNGYSF IINNNGHVLY
HPDLRPLQNN ELYDETLEPQ YISVDLTEVE LVENENGPRE NHSVLLDLRY DMIQQKEGET
ELGVKIHYDN VRRVTTRRHK YFYTPIEGTP FSLGLAIPER YGMYELLAEQ EIKHSQRNVT
DYFKGNNWKV HPDWVYCEYT SGTSGEQWFR TAEERVLHFL SRSRRPGWKW MSLRPRSPSQ
REHHHQTTKK DKDAYFCDKN LLQSLVLDAM VTESLERHHT RTEDDHEGHQ IFGKTLTFVA
TRSGLLRWTD HVTPGEKAQQ PHFSETNVKA MDETWYKRAV DQHSIEPESF VFSVPFDSNL
QENPLITATH AVFVEHNGHR APAAVVGIQY QHTTLASHFL NITSKCTGTT TCHKTCASEK
LDCYVLDNNG FVIISERSEH TGQFFGQIDG TIMDSLVQDR IYKKITVYDY QGACSNSKSH
YSGDAYQVQP FDPIKSFFKY LVKFSWLLLA KIEAAYGTAI AYAQDDEIYP EYDPNFDQFP
TGEDVIGEQD PILPPPYTNT PSFIPPYESD PMEGVDMSQF GVRPCDRKVD LYVLQPDKLN
VSGQSDPLKG KLTNCHVTAC ERPFSVQKIP HSNLILLVVD TMCPCGSKQF SITPHELIYD
TGNGGCLHKP KDSLYRRRPP KCINYHPEVS RSFCLVGVTI VLLQESEINI CGKASIPVAN
VATLLIISAM RYILAVLS
//
