ID A0A139WPL6_TRICA Unreviewed; 1684 AA.
AC A0A139WPL6;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Rho GTPase-activating protein 190-like Protein {ECO:0000313|EMBL:KYB29837.1};
GN Name=AUGUSTUS-3.0.2_04583 {ECO:0000313|EMBL:KYB29837.1};
GN ORFNames=TcasGA2_TC004583 {ECO:0000313|EMBL:KYB29837.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB29837.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB29837.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29837.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB29837.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29837.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971307; KYB29837.1; -; Genomic_DNA.
DR EnsemblMetazoa; TC004583_005; TC004583_005; TC004583.
DR Proteomes; UP000007266; Linkage group 1.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22207; pseudoGTPaseD_p190RhoGAP; 1.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.10.10.440; FF domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF4; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 1.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 430..484
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 597..784
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 783..943
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1469..1675
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 951..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1684 AA; 192330 MW; 1134A52213C7B968 CRC64;
MARKADTVRT INVAVVGLSG MEKDKGHAGV GKSCLCNRFM RSHADDYNVD HISVLSQTDF
SGRVVNNDHF LYWGEVIKTS EEGIDYQFSV IEQTEFIDDA SFQPFKGGKM EPYIKRCAAT
KIQSAEKLMY ICKNQLGIEK EYEQKVLPDG KLNIDGFICV FDVSIVPSRS LEKQVEIVAA
ILNNLVKTKK PVVFVTTKND DANELFVREA DKLIQRKDYK GAVPLVETSA HDNVNVDLAF
MLLAQIIDRS KVRSKITPYV EAARARKELM DVASEAFMRL IRLHVTDCRA LWSHTVKKLN
SHKEWIYFVQ LFGLDGTQRL FRRHIKKLKD EQLAKRIAHY MEMLPDVLHE LVPDINTLTD
SDWPSVQQYL KSHPDFTQYF YECPEDMPWT ECELESDNEE TRIPFDVLEI SDAETVFKNH
INVLQQEQKR LEWKKQFKQL LEDTGYVTPG KHLSEVRVLF MGRECFEALS EHDCQQIYDA
HQRELIENAK HNFQELLLEH ADLFYHFKSI APTGTITQDD IKEIIDVLQD DFRYKMLDRL
DQDRKVMLFQ HLGFIHCPIR EHCPAFPNCM DALIERILAT KAHRPSSWNH SNQWLISSDN
NQLHLLILGA DNLAENLAAK IRAQCEDDEY EIDCQFYSLD YRIINGDVSL PHNSFRTADF
VPHGSFCVYS NAESFEYIRE SLEKTLLSNL EQEDKLPFQG LPIVLMFLQD SYIEEKDVIK
LREEGQSLAD SLQCPFMDVC LDQISEEQLV SDALHQLVQS IHHRAGFLNI YQSVIECVEP
DIRIIMCTFC GDSYSIENVL APLLSHQCCF LSAERSIILE TFLGDSKRKV EVIVSSFHGA
NAFRDELVHG FILVYSTKRK ASLATLNAFS MNIPNLPIQI LAVTDSGGAN AFFNNDLSHL
LITEGNATAD RLHAHFMTTS SSSQQKTAFF TPFFKEVWEK KPEIEQAFHM EEPSGLDDSG
EGTLEHPRSQ RHGHPLPPPR HESYQLKLND GSGSENYELN GPDERLSSSD HSDKYSHIYM
YGNENGDITK KRSLHQGFQV YPPPTTPPEP APPDHPLISR IPKRGPMLSA SQTSLDEITY
GEGDQPVSIS GSAWNNYGQH AFTTGRRHVS VSESRPKGIS QTLKQPGKLN LKNYSVVTEA
IARMNVSGKD IRNTNFGNAP LATPEVVDLG CEYAQVKDMV HNMYPPDAEY MYTLVQDAVS
GKSKLRQRRE KGQPSYSDTD SEWSSLERST SKRAYSDTDS EWSSLERRQR ASEVYSKVNR
KSGTHKRQRK KRTAIPVQPP RVPQLGGFTL PSVHSTPHVD LDPDKTNVGS ESNSDSSEGS
DAEQARTGTA DSRNRFSQKR SFSLKKRVPV SELHNTHNLN IQLHSPDLFS IKPNSYGIIH
DDESSLDVSS PRDNNSPMFG VLPKMKESDR EKLLRKREKQ KAKDDSKLEK QRRLKEEKLR
KVADKEKERD KKKQQKIKQK ALSLSAAPSK LSDFIQNENN YIPIFLEKCV KFIESEGLES
EGIYRVPGNR AHVDLLFQKF DEDPNVDIHE LDIPVNAVAT ALKDFVSKRL PPLFEEDVMS
ELEEIAVPGT RIKPMATTTG NVEVKTDRSC RLLALRSMLE KLPKVNFQVL KFVFQHFVKV
AENSKLNNMD SKNLAICWWP TLLPIEFSDM GRFEQMRPYL EDIVQTMINQ YPFLFCGKEA
FVMV
//
