ID A0A139XF93_9CYAN Unreviewed; 1095 AA.
AC A0A139XF93;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=WA1_12205 {ECO:0000313|EMBL:KYC43360.1};
OS Scytonema hofmannii PCC 7110.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Scytonemataceae;
OC Scytonema.
OX NCBI_TaxID=128403 {ECO:0000313|EMBL:KYC43360.1, ECO:0000313|Proteomes:UP000076925};
RN [1] {ECO:0000313|EMBL:KYC43360.1, ECO:0000313|Proteomes:UP000076925}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7110 {ECO:0000313|EMBL:KYC43360.1,
RC ECO:0000313|Proteomes:UP000076925};
RX PubMed=23221676; DOI=10.1093/gbe/evs117;
RA Dagan T., Roettger M., Stucken K., Landan G., Koch R., Major P.,
RA Gould S.B., Goremykin V.V., Rippka R., Tandeau de Marsac N., Gugger M.,
RA Lockhart P.J., Allen J.F., Brune I., Maus I., Puhler A., Martin W.F.;
RT "Genomes of Stigonematalean cyanobacteria (subsection V) and the evolution
RT of oxygenic photosynthesis from prokaryotes to plastids.";
RL Genome Biol. Evol. 5:31-44(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYC43360.1}.
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DR EMBL; ANNX02000016; KYC43360.1; -; Genomic_DNA.
DR RefSeq; WP_026135320.1; NZ_KQ976354.1.
DR AlphaFoldDB; A0A139XF93; -.
DR STRING; 128403.WA1_12205; -.
DR Proteomes; UP000076925; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KYC43360.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076925};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 384..604
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 197..224
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1095 AA; 125036 MW; D13086F281AA172D CRC64;
MSRSSRPQRQ QANPLAKWLA LDWNRPERSY NPDVRDFLAG LLDYPKDCVV TEDAGGGGYP
DIKLLTPEKI AWVVGDLKKD DAELTTPSGR RKLWNQKRKY VEGLTRYVLF LTARYVWLVL
PTGEAVAGFE APCNLSEITF EELKERLKFL SYEQATHSNQ WATFIDGQLP YVYLKLDAPE
TLARLRQDLQ TSFTELVTAA EQAIATLIQE YEEFKRQEQK IQQNLIDTGD TQRRALVRLR
FKFDFHRHLF EDLLPRFQDQ YGRDVNAKDN KQVEERIRES FVADSVAVLV ARVLFLRLVE
DLKLTKKRRL SNGGPQDWAS FVEQLTGDAK ELVQLVAKDI GRLYHDPFER NLFDWIYETN
GALDEALQRL ILRFNAYDFS GLSEEILGDI YQTFLPTAKR KRLGEFYTPA SIVDWLLEQT
VFTHGEGNLL DPSCGSGSFL VRYVHRCLED AKTRGLDPDT VLQELQTNVW GFDLNPFAAF
ISHFQLMWAL VRFKPSTKDV PKIPVYNLNS LLRESDLVPL LGEGLLAPGS ADRDSKQWKY
IVGNPPYIRA ERVKYNDEMR GLWHQVWGPN ADTGFVFLYR ALTESLQSGG FLGMVVSGGY
ANSEAAAKVW KLLYPAREAA LRKIVWLEFA GKQWDANVIP MLLVIEKTSA QENDEIELYV
PSTWPSNEPP AKIKYKDFFD AKVSPRVTEI DPSNPLEAFW GNYLLPLLHP EDIPILKKLY
PNGNGGNVVE LKEAVARQLN RKNQPIWFTY GIQAGREAQV TESPTGNRPI QTILGRSISL
GWHGEPEGWI NLEDVQKLSI WGDRKIPSFI AVAEVALVPF ACLVDREEVA ARNSVVIALP
KIDGPPSKAI VAFLNSKLVR FYYLIRLRAG VLEGSSRAHI YPRVLDALPW IKNPDSTIEQ
RLVESYNRLA RLAVIAKNNP DEWLLSEVET RIATSRYKLS DKSLGLNFSN WSPEDVQVEE
LSLDGNCIRA GLFSLELINA DIAELVNKLL TLNADEDTTI SRAIIQKLLV PQDYTVVMQN
YRQRLASFQQ VESDFFSVLA HIDETVYEMF GLTDEEKTHI ETRLASFPLN KLQPRYPWQT
VKPRPIKAYT SDRFA
//
