ID A0A140DLW6_9VIRU Unreviewed; 1857 AA.
AC A0A140DLW6;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:AMK49153.1};
OS Marine RNA virus PAL128.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Marnaviridae; Salisharnavirus; Palmarnavirus 128.
OX NCBI_TaxID=1804153 {ECO:0000313|EMBL:AMK49153.1, ECO:0000313|Proteomes:UP000201677};
RN [1] {ECO:0000313|Proteomes:UP000201677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Miranda J.A., Culley A.I., Schvarcz C.R., Steward G.F.;
RT "RNA viruses as major contributors to Antarctic virioplankton.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KT727023; AMK49153.1; -; Genomic_RNA.
DR RefSeq; YP_009230118.1; NC_029306.1.
DR GeneID; 26887286; -.
DR KEGG; vg:26887286; -.
DR Proteomes; UP000201677; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23195; Marnaviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT TRANSMEM 960..976
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 982..1000
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 570..738
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1590..1717
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 104..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..127
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1857 AA; 210512 MW; FAB7FA53EEA773E1 CRC64;
MVSETVNPLN LTTSKSLNLS TENLSTRDQP FNPDLEVGQS SACHAQRLNL NNKNTDPNPW
ILVHRKPNKN EKLPHVYRHI IPPTTNFGFC HECEYEKEFR QNHFAHSRSP SRKVNHKERR
AASRRLHKPK NKDIEPHCQR DGPPPLIGGN KIDSSDEEGS DTESEDIPTN LEPEPESSSS
EEDDFEYSEE VHGRPIIYAA SSTPSIVASY FEDDYSSRVI FEPLHGSMIQ QDILDMYELY
GYGHLITWGI TPHTVKGTDD TPTPPPPPAS RKSGKKFRKE KKEKKVPETF TRDSLFRAAV
DAPASVAPQD KDLHDLLSTI SNVSSGSEDP DVENWTSHLE NLVILGYQMS KATSFTDVFV
SVVGYIKMNT NRSVIKDIMK MIDDVLAPLE EAASPENCND KLNDVHMNGN DVVRNWELFK
GNTIFTKVSY LISAAMSLSV CNIKQIEWSP LGLQLVAFEA CKEQMKAVDV IDAVIHTFTW
FADTGCRCIE QRSLMPLLYQ DNKMQAFNVE CDYLLAHADS YLSGNKGDIS DYDHRVQKTL
AQVSALKATQ TTGPTALWLQ SRYYALIQIQ QRIIAKHKNT AIKFAAFGLC CTGPTSVGKS
TLAKILMKVA LNAMDFSTDE KRIITIDTYD KFDTLFTSDI LGFYLDDIGN TKSTFATRCP
TEMCVKFFNN MAAQAVKAEL NQKGVVFLGP KVGIATSNVE DMDVRSYTNC AESILRRFFF
IRVHIKDKYQ KPGSTMLNKS HPDLVNAALT HDIWRLTIEE TVAFETKEGK SDYRMRTMDV
RVKDGSTIHC EDLDFAECLD VVIALAEQHK IEQDSLVERD KGYNEMTLCK TCKRPTSMCT
TTCQGVLDRA KEEAEDVEPN MFNTDAIQDV VATSIRKATT DYLNAWFAPV MSLNNFLGYS
PAKYCATRKL AGEMTKIFDQ TATPYVVSLT PQWVFDTSLF QQMVDVWYAR RATYDIAVRV
YRFNCMFFPA LLWLLYRKSW RRVSWCLVLY FFLSIIAWSY QRARRKKYKE EYLSRRNALP
DYAESIRDGK ALKGLFVVST LAIGLKMFQM WNKTRTENIP NSSNEQDDAK STWYGLMLSR
MGVSVDVSQA SKRGTASQVK ATLTKSCLFW GKFTRPDGDV ASCNVFFPRK SVVNFPLHAF
YPDNNMNLVP FENLTLLVDR HDGVGGQFTV KISRSQSVVY EGLDMVAAYV PNCPDLGDKS
KWLPLSYPED QSESNCTFLM RKPIGFHSER LKVFHTLVGH KYLSFTGGRY KSDHAKQGAC
MGVLILEQND PVILGFHIGG RLPDKLGVMQ TLLYGNYVKT IKQLEAIPGV ILSANAGNIP
TTQYGISLLN TDTIHPMSMC AKLEKDAFVD LHGSTALRCK QRSTVEKSIL SDDVAEICDI
PNRWHPPELE PNWVGYNATL EHIINPADMF EPDKLERCRQ DWIKPMRDLM KVYSILNDVA
PLTDKQAILG IPGTRFIDPM VMPTGCGFPI YGAKSKRFTD VLDEKGVLID RIPDQEIRDE
ADRQIFCWEN GQRAYPVTAS TLKDEPTDNS KVRVFQASPV ALTMNIRKYF LPIARFMQEH
PTQSECAVGV NPFGKQWTEL MNHANQWSDE WVVSWDYSKY DVRMSSQMTR ACFACYIELA
QMSPLYSDAD INIMKNMIVD IVHPLVDYNG VLFTAYNMNT SGNSLTVTTN SLAGSLYVRM
GFFDVYPDEL CFRDCVAALT YGDDFIGSVR DGYHDFNFES YKTFLAGHKM KITLPDKSDT
VVKFSKKSET DFLKRISCYI PEIGYSVGSL DESSIFKSLH ANVRSTGATR EEVAISCLEG
AMHEWFAHGR EKYELRRQQM LSVAARHDFK ISALDATFDQ RVDFWKQKYD TDHQAAR
//
