ID A0A140G0K7_ISKNV Unreviewed; 298 AA.
AC A0A140G0K7;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=DNA repair protein RAD2 {ECO:0000313|EMBL:QXE50721.1};
DE SubName: Full=Flap endonuclease-1 {ECO:0000313|EMBL:QPO16275.1};
DE SubName: Full=ORF033L {ECO:0000313|EMBL:AMM04440.1};
GN Name=ORF27 {ECO:0000313|EMBL:QPO16275.1};
GN Synonyms=28 {ECO:0000313|EMBL:QXE50721.1};
GN ORFNames=IJGMMPBP_00028 {ECO:0000313|EMBL:QQZ00481.1}, NIDBEMMG_00002
GN {ECO:0000313|EMBL:QQZ00577.1};
OS Infectious spleen and kidney necrosis virus (ISKNV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Alphairidovirinae; Megalocytivirus.
OX NCBI_TaxID=180170 {ECO:0000313|EMBL:AMM04440.1, ECO:0000313|Proteomes:UP000152407};
OH NCBI_TaxID=119488; Siniperca chuatsi (Mandarin fish).
OH NCBI_TaxID=270530; Synchiropus splendidus (Mandarinfish) (Callionymus splendidus).
RN [1] {ECO:0000313|EMBL:AMM04440.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSIV-Ku {ECO:0000313|EMBL:AMM04440.1};
RA Jackson K.R., Lunt B.L., Fisher J.N.B., Gardner A.V., Bailey M.E.,
RA Deus L.M., Earl A.S., Gibby P.D., Hartmann K.A., Liu J.E., Manci A.M.,
RA Nielsen D.A., Solomon M.B., Breakwell D.P., Burnett S.H., Grose J.H.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000152407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wen C.-M., Hong J.-R.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000596309, ECO:0000313|Proteomes:UP000596428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KU1 {ECO:0000313|EMBL:QQZ00481.1}, and KU2
RC {ECO:0000313|EMBL:QQZ00577.1};
RA Kayansamruaj P.;
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QPO16275.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EFIV-2018 {ECO:0000313|EMBL:QPO16275.1}, and EFIV-2019
RC {ECO:0000313|EMBL:QPO16395.1};
RA Koda S.A., Subramaniam K., Pouder D.B., Yanong R.P., Frasca S. Jr,
RA Popov V.L., Waltzek T.B.;
RT "Complete Genome Sequences of Infectious Spleen and Kidney Necrosis Virus
RT Isolated from Farmed Albino Rainbow Sharks Epalzeorhynchos frenatus in the
RT United States.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QXE50721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bali/ Hybrid-grouper/2016/SVC-18-072
RC {ECO:0000313|EMBL:QXE50843.1}, and Bali/Hybrid-grouper/2016/SVC-18-009
RC {ECO:0000313|EMBL:QXE50721.1};
RA Fusianto C., Hick P.M., Murwantoko, Herlambang A., Whittington R.J.,
RA Becker J.A.;
RT "Outbreak investigation attributes Infectious spleen and kidney necrosis
RT virus as a necessary cause of a mortality epidemic in farmed grouper
RT (Epinephelus spp.) in Bali, Indonesia.";
RL Aquac Rep 20:0-100723(2021).
RN [6] {ECO:0000313|EMBL:QXE50721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bali/ Hybrid-grouper/2016/SVC-18-072
RC {ECO:0000313|EMBL:QXE50843.1}, and Bali/Hybrid-grouper/2016/SVC-18-009
RC {ECO:0000313|EMBL:QXE50721.1};
RA Fusianto C.K., Hick P.M., Murwantoko M., Herlambang A., Whittington R.J.,
RA Becker J.A.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; KT781098; AMM04440.1; -; Genomic_DNA.
DR EMBL; MW273353; QPO16275.1; -; Genomic_DNA.
DR EMBL; MW273354; QPO16395.1; -; Genomic_DNA.
DR EMBL; MT128666; QQZ00481.1; -; Genomic_DNA.
DR EMBL; MT128667; QQZ00577.1; -; Genomic_DNA.
DR EMBL; MW464172; QXE50721.1; -; Genomic_DNA.
DR EMBL; MW557381; QXE50843.1; -; Genomic_DNA.
DR RefSeq; NP_612249.1; NC_003494.1.
DR GeneID; 935303; -.
DR KEGG; vg:935303; -.
DR OrthoDB; 21654at10239; -.
DR Proteomes; UP000152407; Genome.
DR Proteomes; UP000594914; Genome.
DR Proteomes; UP000595028; Genome.
DR Proteomes; UP000596309; Genome.
DR Proteomes; UP000596428; Genome.
DR Proteomes; UP000693957; Genome.
DR Proteomes; UP000693973; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF9; FLAP ENDONUCLEASE 1; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000313|EMBL:QPO16275.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000693973}.
FT DOMAIN 1..94
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 163..234
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
SQ SEQUENCE 298 AA; 33452 MW; 807804587954463B CRC64;
MGVKNLNLFL RSVGVTEQWL PYSNFAGKRV AIDAAYLMHR FKAANGNLWD MLLNNFVVAC
VINNKIDMTF VFDGTAPIEK TDELAARATR RAAALLRQQN IAAAVTNGDE SVIDKCKTSV
ARRYNVRADM VTARMVNDYV EHRVRTHQAV TPEDYERMRA ILTGFGVPYT FARTEGEMHC
VQMVANGQAD LVMTIDTDAI LVSALHSVPY VLTNFKAGCF RQVSVHEVLD KCHMTPAQFL
DFCILLGTDF NKHIRGIGHV KARNLIKTHG SIDNMHTVVD TSQLGDYKRV REIFMSYG
//
