ID A0A140HLV7_9CAUD Unreviewed; 340 AA.
AC A0A140HLV7;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN ORFNames=Blue_146 {ECO:0000313|EMBL:AMO25969.1};
OS Bacillus phage Deep Blue.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Herelleviridae; Bastillevirinae; Caeruleovirus; Caeruleovirus deepblue.
OX NCBI_TaxID=1792245 {ECO:0000313|EMBL:AMO25969.1, ECO:0000313|Proteomes:UP000201785};
RN [1] {ECO:0000313|EMBL:AMO25969.1, ECO:0000313|Proteomes:UP000201785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27313285;
RA Hock L., Gillis A., Mahillon J.;
RT "Complete Genome Sequence of Bacteriophage Deep-Blue Infecting Emetic
RT Bacillus cereus.";
RL Genome Announc. 4:0-0(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; KU577463; AMO25969.1; -; Genomic_DNA.
DR RefSeq; YP_009285458.1; NC_031056.1.
DR GeneID; 29081925; -.
DR KEGG; vg:29081925; -.
DR OrthoDB; 8328at10239; -.
DR Proteomes; UP000201785; Genome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0099018; P:evasion by virus of host restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00033479};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000201785};
KW Restriction-modification system evasion by virus
KW {ECO:0000256|ARBA:ARBA00033479};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Viral immunoevasion {ECO:0000256|ARBA:ARBA00033479}.
FT ACT_SITE 76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 340 AA; 38306 MW; D5996DF35CC0104A CRC64;
MEELRVVELF AGYGSQSMAL KRANINYKTV AIAEIDEHAI NSYEAIHSNT YNLGDITKVE
GEDVPDHDFL TYSFPCTDIS VSGAMKGLLE NSGTSSSTLW DVKRVIEAKK PSYLMMENVD
NLVIKFMDDY LLWLAYLNSQ GYTTTWRVID SETYVPQRRK RVIAISQLNG QAFLFPKDPE
ERTYDLIDVL EDLDDAEALE SFKDPSVRSA TVDPVTYYNP NSDYYKLQPE NSRASFIGYI
GNQPKQATRV YEPITASTLT ANGGGQGGKT GLYHLGTHIR NLSPLEAWRV MGVSDEDFYK
AQAVGTKKTQ LLRQAGNSIV VDIMVPIFEK LFKNYMKETN
//
