ID A0A140NFA0_PROSM Unreviewed; 402 AA.
AC A0A140NFA0;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Multidrug resistance protein MdtA {ECO:0000256|HAMAP-Rule:MF_01422};
DE AltName: Full=Multidrug transporter MdtA {ECO:0000256|HAMAP-Rule:MF_01422};
GN Name=mdtA {ECO:0000256|HAMAP-Rule:MF_01422};
GN OrderedLocusNames=S70_01255 {ECO:0000313|EMBL:AFH92149.1};
OS Providencia stuartii (strain MRSN 2154).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Providencia.
OX NCBI_TaxID=1157951 {ECO:0000313|EMBL:AFH92149.1, ECO:0000313|Proteomes:UP000005012};
RN [1] {ECO:0000313|EMBL:AFH92149.1, ECO:0000313|Proteomes:UP000005012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN 2154 {ECO:0000313|EMBL:AFH92149.1,
RC ECO:0000313|Proteomes:UP000005012};
RX PubMed=22740665; DOI=10.1128/JB.00615-12;
RA Clifford R.J., Hang J., Riley M.C., Onmus-Leone F., Kuschner R.A.,
RA Lesho E.P., Waterman P.E.;
RT "Complete Genome Sequence of Providencia stuartii Clinical Isolate MRSN
RT 2154.";
RL J. Bacteriol. 194:3736-3737(2012).
RN [2] {ECO:0000313|Proteomes:UP000005012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN 2154 {ECO:0000313|Proteomes:UP000005012};
RA Clifford R.J., Hang J., Riley M.C., Onmus-Leone F., Kuschner R.A.,
RA Lesho E.P., Waterman P.E.;
RT "Complete genome sequence of Providencia stuartii clinical isolate MRSN
RT 2154.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. {ECO:0000256|HAMAP-Rule:MF_01422}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_01422}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01422}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|HAMAP-
CC Rule:MF_01422}.
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DR EMBL; CP003488; AFH92149.1; -; Genomic_DNA.
DR RefSeq; WP_014656129.1; NC_017731.1.
DR AlphaFoldDB; A0A140NFA0; -.
DR KEGG; psi:S70_01255; -.
DR PATRIC; fig|1157951.4.peg.256; -.
DR HOGENOM; CLU_018816_2_0_6; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000005012; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR HAMAP; MF_01422; MdtA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022824; Multidrug-R_MdtA.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01422};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01422};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01422};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|HAMAP-Rule:MF_01422}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 84..132
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
SQ SEQUENCE 402 AA; 43568 MW; 4331028DF185A2B9 CRC64;
MNKQKRRTTL TRSAIFVAII VAAGAGWYFY SQNTPSDTAQ NSARPTRSNS APHRMLAPVQ
YANAQEKVVP RYLTGLGTVQ AANVVTVTSR VEGQLMSLHF TEGQQVKAGD LLAEIDPRPF
EVQLAQAEGQ LAKDKATLAN ARLDLNRYQK LAGTKVISQQ ELDNQKALVL QAEGSIKVDQ
AAVDNAKLQL TYSKITAPIS GRVGLKQVDV GNFISAGTAT PIVVITQTQP ADVLFALPEG
DIPAVQKAQS SNQPVKVEAW DRNNIAMISE GYLLSIDNQI DPATGTLKMK ARFTNELQTL
FPNQFVNIKM QIETLQNAVV IPTAALQMGN EGHYVWVLND DNRVSKHVVT VGMQDSQQVV
IESGLTANTK VITDGVDRLT DGTSVEVVNT ETASKSAKTT KK
//
