ID A0A140T829_BOVIN Unreviewed; 531 AA.
AC A0A140T829;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Zinc finger and BTB domain containing 18 {ECO:0000313|Ensembl:ENSBTAP00000000497.5};
GN Name=ZBTB18 {ECO:0000313|Ensembl:ENSBTAP00000000497.5,
GN ECO:0000313|VGNC:VGNC:37063};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000000497.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000000497.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000497.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000000497.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000497.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZBTB18 subfamily. {ECO:0000256|ARBA:ARBA00038422}.
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DR RefSeq; NP_001071484.1; NM_001078016.1.
DR AlphaFoldDB; A0A140T829; -.
DR SMR; A0A140T829; -.
DR Ensembl; ENSBTAT00000000497.6; ENSBTAP00000000497.5; ENSBTAG00000000385.6.
DR GeneID; 538793; -.
DR KEGG; bta:538793; -.
DR CTD; 10472; -.
DR VEuPathDB; HostDB:ENSBTAG00000000385; -.
DR VGNC; VGNC:37063; ZBTB18.
DR GeneTree; ENSGT00940000155092; -.
DR InParanoid; A0A140T829; -.
DR OMA; GASDYDM; -.
DR OrthoDB; 783166at2759; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000000385; Expressed in longissimus thoracis muscle and 104 other cell types or tissues.
DR ExpressionAtlas; A0A140T829; baseline and differential.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18324; BTB_POZ_ZBTB18_RP58; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394:SF18; ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 33..100
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 379..406
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 419..446
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 447..474
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 475..498
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 130..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 59368 MW; 20825A2FBC3A6951 CRC64;
MCPKGYEDSM EFPDHSRHLL QCLSEQRHQG FLCDCTVLVG DAQFRAHRAV LASCSMYFHL
FYKDQLDKRD IVHLNSDIVT APAFALLLEF MYEGKLQFKD LPIEDVLAAA SYLHMYDIVK
VCKKKLKEKA TTEADSTKKE EDASSCSDKV ESLSDGSSHM AGDLPSDEDE GEDEKLNILP
SKRDLAAEPG NMWMRLPSDS AGIPQAGGEA EPHATAAGKT VASPCSSTES LSQRSVTSVR
DSADVDCVLD LSVKSSLSGV ENLNSSYFSS QDVLRSNLVQ VKVEKEASCD ESDVGTNDYD
MEHSTVKESV STNNRVQYEP AHLAPLREDS VLRELEREDK ASDDEMMTPE SERVQVEGGM
ESSLLPYVSN ILSPAGQIFM CPLCNKVFPS PHILQIHLST HFREQDGLRS KPAADVNVPT
CSLCGKTFSC MYTLKRHERT HSGEKPYTCT QCGKSFQYSH NLSRHAVVHT REKPHACKWC
ERRFTQSGDL YRHIRKFHCE LVNSLSVKSE ALSLPAVRDW TLEDSSQELW K
//
