ID A0A140T8Q8_MOUSE Unreviewed; 538 AA.
AC A0A140T8Q8;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 {ECO:0000313|Ensembl:ENSMUSP00000105705.4};
GN Name=Kcnn1 {ECO:0000313|Ensembl:ENSMUSP00000105705.4,
GN ECO:0000313|MGI:MGI:1933993};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000105705.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000105705.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105705.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000105705.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105705.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; NP_115773.2; NM_032397.2.
DR RefSeq; XP_006509870.1; XM_006509807.3.
DR RefSeq; XP_006509871.1; XM_006509808.3.
DR ProteomicsDB; 337285; -.
DR Antibodypedia; 27885; 146 antibodies from 24 providers.
DR DNASU; 84036; -.
DR Ensembl; ENSMUST00000110078.5; ENSMUSP00000105705.4; ENSMUSG00000002908.18.
DR Ensembl; ENSMUST00000212611.2; ENSMUSP00000148544.2; ENSMUSG00000002908.18.
DR GeneID; 84036; -.
DR KEGG; mmu:84036; -.
DR AGR; MGI:1933993; -.
DR CTD; 3780; -.
DR MGI; MGI:1933993; Kcnn1.
DR VEuPathDB; HostDB:ENSMUSG00000002908; -.
DR GeneTree; ENSGT00950000182904; -.
DR OMA; PPCQWPP; -.
DR OrthoDB; 4200919at2759; -.
DR BioGRID-ORCS; 84036; 4 hits in 78 CRISPR screens.
DR ChiTaRS; Kcnn1; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000002908; Expressed in hindlimb stylopod muscle and 59 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF38; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 1; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR PRINTS; PR01451; SKCHANNEL.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 104..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 382..461
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 466..493
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 538 AA; 59450 MW; 35F2435796B08B3E CRC64;
MSSHSHNGSV GQPLGSGPGF LGWEPVDPEA GRPLQPTQGP GLQMVAKGQP VRLSPGGSRG
HPQEQEEEEE EEEEEEDKTG SGKPPTVSHR LGHRRALFEK RKRLSDYALI FGMFGIVVMV
TETELSWGVY TKESLCSFAL KCLISLSTVI LLGLVILYHA REIQLFLVDN GADDWRIAMT
WERVSLISLE LVVCAIHPVP GHYRFTWTAR LAFSLVPSAA EADLDVLLSI PMFLRLYLLA
RVMLLHSRIF TDASSRSIGA LNRVTFNTRF VTKTLMTICP GTVLLVFSVS SWIVAAWTVR
VCERYHDKQE VTSNFLGAMW LISITFLSIG YGDMVPHTYC GKGVCLLTGI MGAGCTALVV
AVVARKLELT KAEKHVHNFM MDTQLTKRVK NAAANVLRET WLIYKHTRLV KKPDQGRVRK
HQRKFLQAIH QAQKLRSVKI EQGKVNDQAN TLAELAKAQS IAYEVVSELQ AQQEELEARL
AALESRLDVL GASLQALPGL IAQAICPLPP PWPGPGHLAT ATQSPQSHWL PTMGSDCG
//