ID A0A142L1W5_9BACT Unreviewed; 317 AA.
AC A0A142L1W5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN ORFNames=AEM51_03450 {ECO:0000313|EMBL:AMS26211.1};
OS Bacteroidetes bacterium UKL13-3.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1690483 {ECO:0000313|EMBL:AMS26211.1, ECO:0000313|Proteomes:UP000075224};
RN [1] {ECO:0000313|Proteomes:UP000075224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Driscoll C.B.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-
CC methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH;
CC Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636,
CC ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.54;
CC Evidence={ECO:0000256|ARBA:ARBA00034420};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19823;
CC Evidence={ECO:0000256|ARBA:ARBA00034420};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU003862};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743, ECO:0000256|RuleBase:RU003862}.
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DR EMBL; CP012155; AMS26211.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A142L1W5; -.
DR STRING; 1690483.AEM51_03450; -.
DR KEGG; bbau:AEM51_03450; -.
DR PATRIC; fig|1690483.4.peg.738; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000075224; Chromosome.
DR GO; GO:0106312; F:methylenetetrahydrofolate reductase NADH activity; IEA:RHEA.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003862};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003862};
KW Reference proteome {ECO:0000313|Proteomes:UP000075224}.
SQ SEQUENCE 317 AA; 36064 MW; 484E990C36BFB379 CRC64;
MKVTEHIKNA KSTLFSIEIL PPLKGKDIQS IFDGIDPLME YKPAFVDVTY HREEFVLRKR
KDGGFDKVFT RKRPGTVAIC AALMNRYKID TVPHLICGGF SKEETENALI DLNFLGIDNV
LVLRGDSIKN EPNFIPEPDG NKTSLELLHQ VKNMNNGIYL DEEISNATPS NFCIGVSGYP
EKHFESPNMN SDLRWLKQKI DNGADYIVTQ MFFDNKRFFE FLDQCKKMGI DKPIIPGLKP
LTTKKQLTVL SKLFHIDFPE ELVLEVEKCK DDKAVKQIGI EWAIQQSLEL KNASIPVLHY
YTMGLSEATK AIASKVF
//
