ID A0A143G4J3_9GAMM Unreviewed; 351 AA.
AC A0A143G4J3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=AMD27_09425 {ECO:0000313|EMBL:AMW79085.1};
OS Acinetobacter sp. TGL-Y2.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1407071 {ECO:0000313|EMBL:AMW79085.1, ECO:0000313|Proteomes:UP000076238};
RN [1] {ECO:0000313|Proteomes:UP000076238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TGL-Y2 {ECO:0000313|Proteomes:UP000076238};
RA Zhang G.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP015110; AMW79085.1; -; Genomic_DNA.
DR RefSeq; WP_067659491.1; NZ_CP015110.1.
DR AlphaFoldDB; A0A143G4J3; -.
DR STRING; 1407071.AMD27_09425; -.
DR KEGG; acv:AMD27_09425; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000076238; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000076238}.
FT DOMAIN 24..338
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 351 AA; 39577 MW; C6D0FA5010E6C647 CRC64;
MNHENSHEKN HENNLIIHTQ GALGIITLDR PSHLNALSLE MIQGIQAQFE AWADQPNVQA
ILINSNSPKA FSAGGDIRYL YDAYKNNTSN YRDYFVAEYK MLSTIRQYPK PVLTFLDGYV
LGGGFGLAQA CHILVSSEKS RFAMPETAIG FFPDVGATHF LSRLDDIGVY FAITGEQMSS
SDALYLDLID YHVPSERLAE LLEAISYKPE LDQLQIEQII SRFITDPASS DLRALTAVIH
QHFSPATIEE IESSLAKEQD PLHQAWTEKI LNVLQQRSSI AKQTSLKLQH VGRSLSLEQC
MQLERNLQDI WFEHGDLMEG VRALLIDKDK QPKWQSHNPT LIKIIDDLTA A
//
