UniProt: A0A143HD27

Database: UniProt
Entry: A0A143HD27_9BACL

LinkDB:  A0A143HD27_9BACL 
Original site:  A0A143HD27_9BACL

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (10)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (3)   
Literature (1)   
   PubMed (1)   
All databases (22)   

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ID   A0A143HD27_9BACL        Unreviewed;       606 AA.
AC   A0A143HD27;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE   AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN   ORFNames=ATY39_07945 {ECO:0000313|EMBL:AMW99405.1};
OS   Rummeliibacillus stabekisii.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Rummeliibacillus.
OX   NCBI_TaxID=241244 {ECO:0000313|EMBL:AMW99405.1, ECO:0000313|Proteomes:UP000076021};
RN   [1] {ECO:0000313|EMBL:AMW99405.1, ECO:0000313|Proteomes:UP000076021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PP9 {ECO:0000313|EMBL:AMW99405.1,
RC   ECO:0000313|Proteomes:UP000076021};
RX   PubMed=27231360;
RA   da Mota F.F., Vollu R.E., Jurelevicius D., Seldin L.;
RT   "Whole-Genome Sequence of Rummeliibacillus stabekisii Strain PP9 Isolated
RT   from Antarctic Soil.";
RL   Genome Announc. 4:0-0(2016).
RN   [2] {ECO:0000313|Proteomes:UP000076021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PP9 {ECO:0000313|Proteomes:UP000076021};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; CP014806; AMW99405.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A143HD27; -.
DR   STRING; 241244.ATY39_07945; -.
DR   KEGG; rst:ATY39_07945; -.
DR   OrthoDB; 9802472at2; -.
DR   Proteomes; UP000076021; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR014146; LigD_ligase_dom.
DR   InterPro; IPR014145; LigD_pol_dom.
DR   InterPro; IPR014143; NHEJ_ligase_prk.
DR   NCBIfam; TIGR02778; ligD_pol; 1.
DR   NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR   NCBIfam; TIGR02776; NHEJ_ligase_prk; 1.
DR   PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR   PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF21686; LigD_Prim-Pol; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AMW99405.1};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076021};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          114..206
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   606 AA;  70302 MW;  213B78CDAE83DDB4 CRC64;
     MKPMLLTATE IIPSGADWLF ETKYDGFRCI LEWNKDIELY SRNEGNLSKQ FPEILDFLAS
     IKEKMKSYLP LALDGELVCL ANDYKSEFSI VQSRARLRSK EKIKDQLNHF PCQFVVFDIL
     QIKGKDITNL SFLKRKAKLK ELFEKVSLPV TVMQNNLTSV QMVEPFEDSN QLWKQLVIYN
     GEGVVAKEIS SQWIENTRTN SWLKIKNWRY VNVMVTAYEQ ENNFFIGSVL SEKEFVEVVT
     FKHGMKEEEI KILSQLFKQN GVKINQNRWE LSPSICVKIA CIDFVGGKLR EPRFEAFEFN
     IEPVDCTWHK LEKDLYPLPP SVEITHPDKP IFPLVRIEKD DYLYYLQVIS PYLLPFLFNR
     PLTLIRYPHG VPGESFYQKS APVHVPSFVT VKDDQLYCNN VETLLWLGNQ LAIEYHIPFQ
     PVNSSGPTEI VFDLDPPSVE AFHLTLEAAN QMKVIFDGLG FLSFIKTSGG KGMQIYIPLP
     ANSFTYEDTG LFTKFICDFL IEQAPSLYTI ERLKKNRRKK LYLDYVQHRE GKTIIAPYSP
     RGNESGFIAT PLEWEEVKPG LTPDQFTIPV MIERVRAKGD LFRHFRKNVN NNEEALTRFL
     RELKGE
//

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