ID A0A143HIF4_9GAMM Unreviewed; 518 AA.
AC A0A143HIF4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:AMX01286.1};
GN ORFNames=A3224_00665 {ECO:0000313|EMBL:AMX01286.1}, SAMN05660479_01451
GN {ECO:0000313|EMBL:SFC30882.1};
OS Microbulbifer thermotolerans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=252514 {ECO:0000313|EMBL:AMX01286.1, ECO:0000313|Proteomes:UP000076077};
RN [1] {ECO:0000313|Proteomes:UP000076077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAU221 {ECO:0000313|Proteomes:UP000076077};
RA Lee Y.-S., Choi Y.-L.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AMX01286.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAU221 {ECO:0000313|EMBL:AMX01286.1};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SFC30882.1, ECO:0000313|Proteomes:UP000181967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19189 {ECO:0000313|EMBL:SFC30882.1,
RC ECO:0000313|Proteomes:UP000181967};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP014864; AMX01286.1; -; Genomic_DNA.
DR EMBL; FOKT01000004; SFC30882.1; -; Genomic_DNA.
DR RefSeq; WP_067150123.1; NZ_JAPHQG010000025.1.
DR AlphaFoldDB; A0A143HIF4; -.
DR STRING; 252514.A3224_00665; -.
DR GeneID; 76606556; -.
DR KEGG; mthd:A3224_00665; -.
DR OrthoDB; 6278312at2; -.
DR Proteomes; UP000076077; Chromosome.
DR Proteomes; UP000181967; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000076077}.
FT ACT_SITE 84
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 18..21
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 84
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 191
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 339
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 352
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 518 AA; 58197 MW; EC15588C403C4916 CRC64;
MTEQTHDNNI RHIVIAGGGT AGWSAAAALA RVLAGSGSTI TLVESEAIGT VGVGEATIPT
IHTFHRMLGI DETEFVRATQ ATFKLGIEFR GWGSADNRYF HPFGHYGREF DSIPFHQYWL
YGSRFEDCGN LSEYSLCTLA AERGRFLPAN SDPRSILSQL GYAYHFDAGL YAKFLRNYAE
RLGVRRQEGQ VVDVTLRKED GAIRELVMAS GQRVEGDFFI DCTGFAGLLI GGALNVGYED
WSHLLPANSA VAVPSENVGP TAPYTRSTAA AGGWQWRIPL QHRTGNGFVY SSRFLSDEQA
VETLLQNLEG RALAEPRQLR FTTGRRKKFW HKNCVALGLA AGFMEPLEST AIHLVQTSIS
RLLLLFPGRE LHPADIEEFN RQTAREYEYI RDFIILHYHA NQRSEPLWQY CREMPVPETL
THRIALFRNR GRFFEREEDL FKTASWLAVL MGQGIQPQGY HPVMEGKTPQ KVLGMLREMR
ELLRSGAEAM PTHDEFIAQN CRAPSPSEPL VNSHSRSR
//
