ID   A0A143HPX9_9GAMM        Unreviewed;       916 AA.
AC   A0A143HPX9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=F5/8 type C domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A3224_15370 {ECO:0000313|EMBL:AMX03783.1};
OS   Microbulbifer thermotolerans.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Microbulbiferaceae; Microbulbifer.
OX   NCBI_TaxID=252514 {ECO:0000313|EMBL:AMX03783.1, ECO:0000313|Proteomes:UP000076077};
RN   [1] {ECO:0000313|Proteomes:UP000076077}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DAU221 {ECO:0000313|Proteomes:UP000076077};
RA   Lee Y.-S., Choi Y.-L.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC       oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC       recognize Lewis A antigen and has low affinity for monovalent haptens.
CC       {ECO:0000256|ARBA:ARBA00002219}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC   -!- SIMILARITY: Belongs to the fucolectin family.
CC       {ECO:0000256|ARBA:ARBA00010147}.
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DR   EMBL; CP014864; AMX03783.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A143HPX9; -.
DR   STRING; 252514.A3224_15370; -.
DR   KEGG; mthd:A3224_15370; -.
DR   Proteomes; UP000076077; Chromosome.
DR   GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR   GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR   GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR   CDD; cd04080; CBM6_cellulase-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 3.
DR   InterPro; IPR006584; Cellulose-bd_IV.
DR   InterPro; IPR005084; CMB_fam6.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR006585; FTP1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006626; PbH1.
DR   PANTHER; PTHR45713:SF6; F5_8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03422; CBM_6; 1.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   SMART; SM00606; CBD_IV; 1.
DR   SMART; SM00607; FTP; 1.
DR   SMART; SM00710; PbH1; 3.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 3.
DR   PROSITE; PS51175; CBM6; 1.
DR   PROSITE; PS50022; FA58C_3; 2.
PE   3: Inferred from homology;
KW   Lectin {ECO:0000256|ARBA:ARBA00022734};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076077}.
FT   DOMAIN          1..138
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   DOMAIN          141..290
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   DOMAIN          301..436
FT                   /note="CBM6"
FT                   /evidence="ECO:0000259|PROSITE:PS51175"
FT   REGION          314..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  98320 MW;  B97C67B3F36C7D2E CRC64;
     MLSSLYGVSA FAIDPVSVTA SSNDGNIPEN TLDNNLETRW SAIGDGQWIE YDLGKNYIVK
     DVQIAFYKGD QRTATIEIQV SSDGNTWESL FYGDQPSKTL DLQIFDVDDT EARYVRIVGY
     GNTSNNWNSF TEVAISASEV ASGEIVNLAL GKSTSQSSTD YSGISSRAVD GDVRGNWSSN
     TITHTENEIQ PWWQVDLGSV STISTINLYN RTDSCCSSRL SNFYVLVSDK PFSSNDLNVL
     LAQDDVASYY YGSTAGSPTS IDINRSGRYV RVQLAGSNPL SLAEVEVYGV EATGSLFIVP
     GKIEAEDFGS YADADSENRG GAYRPDEGVD IQETTDSGGG YNVGWMDAGE WLEYPIYVSN
     TGEYSAQLRL ASPSDTGQIS IEVDGVVVAQ HGVASTGGWQ NWNTEEVYLG NISAGTHTLR
     INVESAAFNL NWLNIIDNDS SIREGATYVG GGGTVAGALP ISCETPAGFT LVDSLPEMIE
     AMGKNNVKVA LKPGTYVIDE SDTSLFTSQS LPGGKAASTL LPVDGHNSHY DFRCAYIKFD
     TDLWRQFGKN EVIQLRTVGN YNTISNLSIE DIGDTSPSGG ALGVMMDGRD NVIEGLIITS
     RGSQPYGLGD AYGKGAGPVL SHQKHSSVLI RGLRNTFRNS TVFNYSYGHS VFMQGSEDTL
     IDGIYVQGEL RSTEDMLAAN NPRFAAADAR AASVDFMTVW GYKLPTGYWM SLQEAGIRAY
     NGGNTIIDGV EYERGADTVT VLNSVIRNTR TGVTLVHATG SKYVENTTVI GCEQGYSIGS
     GNIVNSYADA DVGPVITFAY SSDNGTKADI TVLPTDGSKN GWGALAFIGG KNHDITLRSS
     QTDIPSNLQV VLSGDKHSIR HLEDSLQNQD QLTLTSSVVN NLTNFPVLIN NLASGVNGQS
     NGPVSGNTSD NNIQQN
//