ID A0A143Q3M0_9NOCA Unreviewed; 516 AA.
AC A0A143Q3M0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Adenylate cyclase 2 {ECO:0000313|EMBL:AMY17446.1};
DE EC=4.6.1.1 {ECO:0000313|EMBL:AMY17446.1};
GN Name=cyaB_1 {ECO:0000313|EMBL:AMY17446.1};
GN ORFNames=A3Q40_00031 {ECO:0000313|EMBL:AMY17446.1};
OS Rhodococcus sp. PBTS 1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1653478 {ECO:0000313|EMBL:AMY17446.1, ECO:0000313|Proteomes:UP000076180};
RN [1] {ECO:0000313|EMBL:AMY17446.1, ECO:0000313|Proteomes:UP000076180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBTS 1 {ECO:0000313|EMBL:AMY17446.1,
RC ECO:0000313|Proteomes:UP000076180};
RX PubMed=27284129;
RA Stamler R.A., Vereecke D., Zhang Y., Schilkey F., Devitt N., Randall J.J.;
RT "Complete Genome and Plasmid Sequences for Rhodococcus fascians D188 and
RT Draft Sequences for Rhodococcus Isolates PBTS 1 and PBTS 2.";
RL Genome Announc. 4:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000076180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBTS 1 {ECO:0000313|Proteomes:UP000076180};
RA Stamer R., Vereecke D., Zhang Y., Schilkey F., Devitt N., Randall J.;
RT "Complete Genome and Plasmid Sequences for Rhodococcus fascians D188 and
RT Draft Sequences for Rhodococcus spp. Isolates PBTS 1 and PBTS 2.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; CP015219; AMY17446.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A143Q3M0; -.
DR STRING; 1653478.A3Q40_00031; -.
DR KEGG; rhu:A3Q40_00031; -.
DR PATRIC; fig|1653478.3.peg.32; -.
DR Proteomes; UP000076180; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AMY17446.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000076180};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 254..306
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 338..461
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 516 AA; 55999 MW; C59A7243F1EF59F7 CRC64;
MSARPGKFSF VLVPVRAVER TLRSRWPVYL ASMLLANLLG SILVFAFVRY GLPIPENQSI
VVDRVRNVVI FGAYLIFAAV VSLVTAAIML RSVMRWQLRG GPPTRAEQMA ALHAPLRQAI
VHLVLWIIGG ILFMALTAAE MPSLAVAVAV TVAMAAAITF GFTYMLGERI LRPVAAQALS
EGRFDRTMTP GVGTRMAMTW GLGTLIPVTG ILLLCATQLT TDLVFSPDAL AIAIALLCIL
AIVQAFCLSM LTASQISDPI RQLRRAIERV QRGDTEVQVE VFDGSEIGRL QVGFNRMMQD
SSERKVLREL FGQHVGEDVA RRALQFGTEL GGETRFVAVL FVDMVGSTAA ASERPPGEVV
DLLNDFFRVV VDVVDRHHGF VNKFVGDAAL AIFGAPLDRP DAPTAALSAA RELRSELHGI
VGLDIGIGVS AGLAVAGNIG AQERFEYTVI GDPVNEASRL TELAKFQPSR VLASTSALYF
ADEDEQSHWE LGEKVQLRGR RRATHLATPV VYPDPD
//
