ID A0A143Q6T8_9NOCA Unreviewed; 864 AA.
AC A0A143Q6T8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Dimodular nonribosomal peptide synthase {ECO:0000313|EMBL:AMY18820.1};
GN Name=dhbF_3 {ECO:0000313|EMBL:AMY18820.1};
GN ORFNames=A3Q40_01430 {ECO:0000313|EMBL:AMY18820.1};
OS Rhodococcus sp. PBTS 1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=1653478 {ECO:0000313|EMBL:AMY18820.1, ECO:0000313|Proteomes:UP000076180};
RN [1] {ECO:0000313|EMBL:AMY18820.1, ECO:0000313|Proteomes:UP000076180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBTS 1 {ECO:0000313|EMBL:AMY18820.1,
RC ECO:0000313|Proteomes:UP000076180};
RX PubMed=27284129;
RA Stamler R.A., Vereecke D., Zhang Y., Schilkey F., Devitt N., Randall J.J.;
RT "Complete Genome and Plasmid Sequences for Rhodococcus fascians D188 and
RT Draft Sequences for Rhodococcus Isolates PBTS 1 and PBTS 2.";
RL Genome Announc. 4:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000076180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PBTS 1 {ECO:0000313|Proteomes:UP000076180};
RA Stamer R., Vereecke D., Zhang Y., Schilkey F., Devitt N., Randall J.;
RT "Complete Genome and Plasmid Sequences for Rhodococcus fascians D188 and
RT Draft Sequences for Rhodococcus spp. Isolates PBTS 1 and PBTS 2.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP015219; AMY18820.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A143Q6T8; -.
DR STRING; 1653478.A3Q40_01430; -.
DR KEGG; rhu:A3Q40_01430; -.
DR PATRIC; fig|1653478.3.peg.1435; -.
DR Proteomes; UP000076180; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44845:SF4; NONRIBOSOMAL PEPTIDE SYNTHASE INPA; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076180};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 765..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 519..598
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 90645 MW; 00BEBEFCC3E5C6EB CRC64;
MSLDSAHAAP GASGIAAVPA TRMSDTRTPD TAETDPSVFA RLARVARRDP AARAVTTSTR
SITYGELVAA ARRCAAALCS AHGVGGPTAV PIAVIADSSV ETVIAACAVL ASGHPLVLVD
DRLPRQKRAA VLASAGAVVA DRPLSGTAVE VLPPPVTRVD RGRTAMVCFT SGSTGDPKGV
VLDHGGVAGK ADDLRTAVGL TPSDVVGCLL PVSFGAGTTA LLAGLLSGST VALWDPRVSD
PAALGDWLRA VGATTMHASV ALVRSLSAPD GPRPVVETVR AVVTYGEPLL GVDVVRCRDA
LAPRADILNW YAVTECGVVA WSRVSPTDDV PEGRVRAGRA VPGRRLDVVG EDGRAVAPGS
AGEVIVRGGR PAVGYLGRES DRFGVDAEGV PFFRTGDRGR VDDEGLLHLL GRLDDAVKIR
GYLVEPGEVA AAVAGVEGVA DVAVTSTEVD DRTELVAYVA CVRGHDAQRV VRAVRASAGD
RLPQWMIPRF VVPLERIPRT TRGKVDRAAL PAPEVTTPSA RTRTSSSLTV VATSELVGTA
LGVTVDLDDD LVAAGADSLS FVRMATMVRE RFHVDLDPAR VAAEPTVRAI ADLIDETTRA
GSRSRRGTGV LVPLRETGTG VPLFVVTGAG APAVSLIPLV RRLDPERPVY GLQAHGLESR
ARPDRTVRAA ARRYVEQIRR VRPTGPYALA GHSMGGIVAL EMASMLHDAG EDVVEVVVVD
SRLTTALLDG VDAAAEEAPE SAGVDPDAVY EKLRLSLPAL LRIRLQMMVA GYVTFAPITQ
WMLFYNKGLR MLKGHTPRTY PGSVTVLRTA GNEQDDRVWS RVVTGRISIA DVPGSHTDLL
REPHVESVAR EIERAVADIT VPAH
//
