ID   A0A143X171_9FIRM        Unreviewed;       426 AA.
AC   A0A143X171;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Permease IIC component {ECO:0000256|PIRNR:PIRNR006351};
GN   Name=gmuC_1 {ECO:0000313|EMBL:CVH76352.1};
GN   ORFNames=BN3662_01521 {ECO:0000313|EMBL:CVH76352.1};
OS   Clostridiales bacterium CHKCI006.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=1780379 {ECO:0000313|EMBL:CVH76352.1, ECO:0000313|Proteomes:UP000198633};
RN   [1] {ECO:0000313|EMBL:CVH76352.1, ECO:0000313|Proteomes:UP000198633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHKC6 {ECO:0000313|EMBL:CVH76352.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active -transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane.
CC       {ECO:0000256|PIRNR:PIRNR006351}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FCNA01000075; CVH76352.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A143X171; -.
DR   STRING; 1780379.BN3662_01521; -.
DR   OrthoDB; 1641940at2; -.
DR   Proteomes; UP000198633; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR004501; PTS_EIIC_3.
DR   InterPro; IPR004796; PTS_IIC_cello.
DR   PANTHER; PTHR33989; -; 1.
DR   PANTHER; PTHR33989:SF4; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIC COMPONENT; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   PIRSF; PIRSF006351; PTS_EIIC-Cellobiose; 1.
DR   PROSITE; PS51105; PTS_EIIC_TYPE_3; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR006351};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198633};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW   ECO:0000256|PIRNR:PIRNR006351};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR006351}.
FT   TRANSMEM        33..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        81..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..407
FT                   /note="PTS EIIC type-3"
FT                   /evidence="ECO:0000259|PROSITE:PS51105"
SQ   SEQUENCE   426 AA;  46684 MW;  B3E4A4B8BC3AE186 CRC64;
     MAKDTSKMDF IQEKVTPAVT KFVNLKFIKC MQAGIVACMN ATMIGSIFML LMTAPFPQDS
     TWAIARAWRE FSAANAEWLN LGYQIGLNAA GFYILIGMVI AVCEHDKMKI ANNMVMSVFS
     FIVLQCSFLA DGGLDIGFWG AKGMMAAIVV GYCVPELNNW LLNHGFKIKL PDSVPPFVAE
     PINQIFSSII VVIAVFAVKL GFGYFGQTLG GFINNIFTPL FSASDSLTAV LLYCILVRIL
     WFFGLHGNNI AGSVVNVFLT TNLVENAEAV ANGQQPTHIF NSAFQNWTTT GILAIVLAIL
     IVAKSQQLKA ISRISLVPAL FNIGEPLTFG LPLVLNFDIF IPYLIVFAIN GTVPYLACEW
     GLMNIPYLSV PFTIPAIIKV FLMSMDFRAI IVYLVNMILC IAVMIPALKR YDRKLCAEEA
     AASEAA
//