ID   A0A143XFC8_9BACT        Unreviewed;       282 AA.
AC   A0A143XFC8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Morphine 6-dehydrogenase {ECO:0000313|EMBL:CVI65709.1};
DE            EC=1.1.1.218 {ECO:0000313|EMBL:CVI65709.1};
GN   Name=morA {ECO:0000313|EMBL:CVI65709.1};
GN   ORFNames=BN3659_00264 {ECO:0000313|EMBL:CVI65709.1};
OS   Alistipes sp. CHKCI003.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC   Alistipes.
OX   NCBI_TaxID=1780376 {ECO:0000313|EMBL:CVI65709.1, ECO:0000313|Proteomes:UP000198813};
RN   [1] {ECO:0000313|EMBL:CVI65709.1, ECO:0000313|Proteomes:UP000198813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHKC3 {ECO:0000313|EMBL:CVI65709.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FCNT01000012; CVI65709.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A143XFC8; -.
DR   STRING; 1780376.BN3659_00264; -.
DR   OrthoDB; 9804790at2; -.
DR   Proteomes; UP000198813; Unassembled WGS sequence.
DR   GO; GO:0050109; F:morphine 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   CDD; cd19133; AKR_AKR5F1; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:CVI65709.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198813}.
FT   DOMAIN          21..256
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        48
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         106
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            73
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   282 AA;  32422 MW;  DD43211EAA6B750A CRC64;
     MKDVRLNNGV RMPAIGFGVF QIPENETERV VTGAIETGYR LIDTAAAYFN EEQVGDAIRR
     SGVKREEFFI TTKLWVQDYE YDDALRAFDL SMKKLGLDYL DLYLMHKPYG NYYAAWRAME
     RLYMEGRIRA IGVTSFSNER LQDLFLHNEI KPAVNQLETH PFFQQQAANT FLQQEGIQHE
     AWAPFAEGQN DIFNHPVLKE IAARHGKGVG AVILRWLNQR NIVVIPKTVR RERMAENFHI
     LDFTLSDAEM AAIATLETGR SPIYDDMDLP TVKGIGLHKI HE
//