ID A0A143XG76_9FIRM Unreviewed; 399 AA.
AC A0A143XG76;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
DE AltName: Full=Acetoacetyl-CoA thiolase {ECO:0000256|ARBA:ARBA00030755};
GN Name=thlA_1 {ECO:0000313|EMBL:CVI66193.1};
GN ORFNames=BN3660_00445 {ECO:0000313|EMBL:CVI66193.1};
OS Eubacteriaceae bacterium CHKCI004.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae.
OX NCBI_TaxID=1780380 {ECO:0000313|EMBL:CVI66193.1, ECO:0000313|Proteomes:UP000199324};
RN [1] {ECO:0000313|EMBL:CVI66193.1, ECO:0000313|Proteomes:UP000199324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHKC4 {ECO:0000313|EMBL:CVI66193.1};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; FCNR01000017; CVI66193.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A143XG76; -.
DR STRING; 1780380.BN3660_00445; -.
DR Proteomes; UP000199324; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF107; 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:CVI66193.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199324};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:CVI66193.1}.
FT DOMAIN 4..260
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 270..394
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 384
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 399 AA; 42735 MW; A4D3DB5EDF8627C1 CRC64;
MKDVVIVSAC RTPIGKFLGM FKDVSARELA MTAGKEAINR AGIEPAMIDN VVVGQVYAGM
QGSLPAKQIS YRLGCPAESN ACVVNQNCAS GMRALEIACD NIAMGKSEIG LVIGVENMTQ
APYMLPKARG GYRMGNAEVV DSMLHDALID ELSGGHMGVT AENVAKLYGI TREECDELAL
RSHRLACKAI DEGKFKEEIV PVEVKMKKKT ILATEDEHPI RDCNMETLSK LRPAFIKDGV
VTAANASGIN DAAAAVVVMS LDKAKELGVT PLLKMINICA AGVKPEIMGV GPAEAIPKAL
KLAGLKYEDV DYWEINEAFA PQFIGCGRQL EKNYGIKINM DRTNVNGSGI ALGHPIGCTA
LRIIVSMYYE MKRNDYKIGG AALCVGTGPA MASLWTTEI
//