ID   A0A143XLU3_9FIRM        Unreviewed;      1046 AA.
AC   A0A143XLU3;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Mannosylglycerate hydrolase {ECO:0000313|EMBL:CVI68814.1};
DE            EC=3.2.1.170 {ECO:0000313|EMBL:CVI68814.1};
GN   Name=mngB_1 {ECO:0000313|EMBL:CVI68814.1};
GN   ORFNames=NDGK_01345 {ECO:0000313|EMBL:CVI68814.1};
OS   Clostridiales bacterium CHKCI001.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=1780378 {ECO:0000313|EMBL:CVI68814.1, ECO:0000313|Proteomes:UP000198774};
RN   [1] {ECO:0000313|EMBL:CVI68814.1, ECO:0000313|Proteomes:UP000198774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHKC1 {ECO:0000313|EMBL:CVI68814.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FCNS01000014; CVI68814.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A143XLU3; -.
DR   STRING; 1780378.NDGK_01345; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000198774; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:CVI68814.1};
KW   Hydrolase {ECO:0000313|EMBL:CVI68814.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198774}.
FT   DOMAIN          527..607
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1046 AA;  121250 MW;  C6301B88750C35A2 CRC64;
     MFLTERKLER RVQELKKFRY RELRHIGIFL AKEDTEKKTN PEVPTDFEGW TSMKAGTLEK
     EGGDRWKGRD LYLWLHTEFT IPEEFSGKRV VGIFDFGKTG AGNNSGFEAM LYIDGKPYQG
     VDINHQEVFF PEEMVGKTIN ATFRLWSGLE GGGIPKPQEH QLRRADLAYL DEATDDLYYM
     GTLIHETVLN LEEGNPFKYD LLSAMNRAFN LIDWHCAGDE GFYESVALAD KTLNDAVDQM
     NKTSEVHVTC VGHTHIDMAW LWRLKHTREK ASRSFSTVLR MMEQYPEYIF LQTQPQIYQY
     IKEDFPEIFE KIKERVAEGR WEADGAMWVE ADCNLTSGES LTRQILLGCK FIKDEFGKDC
     EYLWLPDVFG YSWALPQILK KSGINMFMTT KISWNQYNRM PHDTFKWIGI DGSEVLTHFI
     TTPEPWSEPG SWFYTYNGLL TAKTVKGIWD AYSEKAINKD LLISFGYGDG GGGVNRDLLE
     NRRRIDKIPG LPTLKTGRAG DYFRKLKETV ANTEEYVPSW DGELYLEYHR GTYTSHAYNK
     KMNRKMELLY REAEWLTAMN AVQNGNLEMA KQDELTEGWK IILTNQFHDI IPGSSIHDVY
     DDCIVDYNKT EKIALEVEED AKKGFIQLSE NTYSVMNNSG WVRDEIVAVP VTEEGSFVAS
     DGTKLKTQKE ENITYVEVKN VPAMGFEVIH FEAEPTEQEA AVFTMSANHI ETPFYVIDLN
     EYGQITRLYD KENEREVIRE GERANVLQIF EDKPLDNEAW DIDIFYQQKM QEVTDLEKIE
     VAECGNLRAV LHMEWKFDAS VIKQDMIFYA DDRRIDFKTW VDYYEVKQLL KVAFPVDIRA
     TYATYDVQYG NVKRPNHWNT SWDQARFETV AHKWVDLSEH NYGVSLLNDC KYGHDIKGNV
     IRLTLIKTAT NPDHLQDLGV HEFTYSLLPH NGDYVIGNTV KEAYALNQPL TVMDGKASLQ
     GSFIELDNPY VELDAVKRSE DKEYLVIRFH EYTGSKRNVG VTLNFAYDGW MESDLRERPI
     ESLHTEKEIQ LEIKPFEIKT ILVKLA
//