ID A0A143XTG1_9FIRM Unreviewed; 552 AA.
AC A0A143XTG1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN ORFNames=BN3660_01870 {ECO:0000313|EMBL:CVI70382.1};
OS Eubacteriaceae bacterium CHKCI004.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae.
OX NCBI_TaxID=1780380 {ECO:0000313|EMBL:CVI70382.1, ECO:0000313|Proteomes:UP000199324};
RN [1] {ECO:0000313|EMBL:CVI70382.1, ECO:0000313|Proteomes:UP000199324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHKC4 {ECO:0000313|EMBL:CVI70382.1};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:43474; EC=3.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000926};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; FCNR01000044; CVI70382.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A143XTG1; -.
DR STRING; 1780380.BN3660_01870; -.
DR OrthoDB; 9766150at2; -.
DR Proteomes; UP000199324; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR InterPro; IPR010766; DRTGG.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR Pfam; PF07085; DRTGG; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CVI70382.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000199324}.
FT DOMAIN 81..138
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 258..315
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 552 AA; 62171 MW; 08F5071599C4AC40 CRC64;
MGDKKNVYVI GHKNPDTDSI CAAISYAYLK NEIAARDGLD YFYIPARNGH VNEETQFVLK
HFDVPQPLYL TDIRPQVLDI EIRKTAGISA DLSLKKAWDI MRTSRIVSLP ILDNEELAGI
ITVGDIAYSD MDVYDNMILS KAGTSYKNIV ETIDGEMVVG DMDGNFDEGH VLIAAANPDM
MEDIIEPYDM VILGNRYESQ LCAIEMEAQC IIVCMGAPVS KTIRKLAKER GCRIIVSPYD
TYIVARLINH SMPVRYFMTT ENLTTFRTVD FVDDIQEIMA KKRFRDFPIV DTQNKYVGMI
SRRNLLDLDR KRIILVDHNE KTQAVDGFEE ADILEIIDHH RLGNLETNAP LFFRNQPVGC
TSTIVTQMYM ENDISIPPYI AGLMCSAIIS DTLMFRSPTC TAIDRLIAEK LAGIAEIDIE
DYAKNMFDAG SNLTAKSAKE IFYQDFKKFN DNKINFGVGQ ISAMNKEQLS ACKEKLLTYM
AEVKDSYKLD MLFFMLTDIL TESTELLLLG DMCKEVLEGA FPVKVEGTSV ELPGVVSRKK
QLIPAILGQL PK
//
