ID A0A143Y8L1_9LACT Unreviewed; 759 AA.
AC A0A143Y8L1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN ORFNames=TR210_375 {ECO:0000313|EMBL:CZQ84613.1};
OS Trichococcus ilyis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Trichococcus.
OX NCBI_TaxID=640938 {ECO:0000313|EMBL:CZQ84613.1, ECO:0000313|Proteomes:UP000076878};
RN [1] {ECO:0000313|EMBL:CZQ84613.1, ECO:0000313|Proteomes:UP000076878}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Trichococcus_R210 {ECO:0000313|EMBL:CZQ84613.1};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR EMBL; FJNB01000002; CZQ84613.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A143Y8L1; -.
DR STRING; 640938.TR210_375; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000076878; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000256|RuleBase:RU364053};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000256|RuleBase:RU364053}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 9..288
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 289..565
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 643..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 759 AA; 86290 MW; B6495F4414A44F36 CRC64;
MQQKHDLIKG MNPRQAEAVL ATEGPLLIMA GAGSGKTRVL THRMAYLLEE KSVNPWNILA
ITFTNKAAKE MKERVIRLVG TVGNDMWVST FHSMCVRILR RESEQIGYAR SFTICDQSET
ETLMKRIIRE KNLDSKKFDH RMILGRISQA KNELQTPKEF SEFAGGYIDN IVYECYKDYQ
KALENSQSMD FDDLILLTVK LFKEHPETLS YYQNKFHYIH VDEYQDTNYA QYQLVQLLAS
KFKNICVVGD ADQSIYGWRG ADMENILNFE KDYPDAKVVL LEQNYRSTKK ILRAANDVIQ
NNVNRKEKEL WTDNPEGDNI VYFRGQSEHD EARYVITKML KEVRENKRQY GDFAVLYRTN
AQSRVIEENL LKSNIPYKMV GGRKFYDRKE IKDLLAYLRL IVNPADDLSF GRIVNVPKRG
IGDASVEKLR EFADMHNLTL LQAAHDVALS SVSGKAAKEL KKFATTMDNL QKMQEFLPIT
ELVQEMLSQT TYLEALEMEK TLESEARIEN INEFLSVTQE FDKTNADNLD LTSFLTDLAL
VSDLDQIEEE PQSEVTLMTM HAAKGLEFPI VFIIGMEDGI FPSSRAFMDE DQMEEERRLA
YVGITRAEQK LFLTNAYSRT LYGRSMSNPA SRFLDELDGS VLDREDSSGS TSTPSSFSSR
PASSGNRWKT ASDTRQEKAF SQPFSAGARE KTTQSVQQTG NSGADRLGWA VGDKASHKKW
GVGVVVQTSG EGDGLTLDIA FKNIGIKRLL ASFAPIEKA
//