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Database: UniProt
Entry: A0A144PRL9_9GAMM
LinkDB: A0A144PRL9_9GAMM
Original site: A0A144PRL9_9GAMM 
ID   A0A144PRL9_9GAMM        Unreviewed;       335 AA.
AC   A0A144PRL9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Delta-aminolevulinic acid dehydratase {ECO:0000256|ARBA:ARBA00020771, ECO:0000256|RuleBase:RU000515};
DE            EC=4.2.1.24 {ECO:0000256|ARBA:ARBA00012053, ECO:0000256|RuleBase:RU000515};
GN   ORFNames=A3K91_1954 {ECO:0000313|EMBL:AMT97545.1};
OS   Psychrobacter alimentarius.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Psychrobacter.
OX   NCBI_TaxID=261164 {ECO:0000313|EMBL:AMT97545.1, ECO:0000313|Proteomes:UP000076104};
RN   [1] {ECO:0000313|EMBL:AMT97545.1, ECO:0000313|Proteomes:UP000076104}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PAMC 27889 {ECO:0000313|EMBL:AMT97545.1,
RC   ECO:0000313|Proteomes:UP000076104};
RA   Lee J., Kim O.-S.;
RT   "Genome sequencing of Psychrobacter alimentarius PAMC 27889.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen;
CC         Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00001227,
CC         ECO:0000256|RuleBase:RU000515};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004694}.
CC   -!- SUBUNIT: Homooctamer. {ECO:0000256|RuleBase:RU000515}.
CC   -!- SIMILARITY: Belongs to the ALAD family. {ECO:0000256|ARBA:ARBA00008055,
CC       ECO:0000256|RuleBase:RU004161}.
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DR   EMBL; CP014945; AMT97545.1; -; Genomic_DNA.
DR   RefSeq; WP_062845092.1; NZ_CP014945.1.
DR   AlphaFoldDB; A0A144PRL9; -.
DR   STRING; 261164.A3K91_1954; -.
DR   KEGG; pali:A3K91_1954; -.
DR   PATRIC; fig|261164.3.peg.2050; -.
DR   OrthoDB; 9805001at2; -.
DR   UniPathway; UPA00251; UER00318.
DR   Proteomes; UP000076104; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004655; F:porphobilinogen synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04823; ALAD_PBGS_aspartate_rich; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR001731; ALAD.
DR   InterPro; IPR030656; ALAD_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   PANTHER; PTHR11458; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   PANTHER; PTHR11458:SF0; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   Pfam; PF00490; ALAD; 1.
DR   PIRSF; PIRSF001415; Porphbilin_synth; 1.
DR   PRINTS; PR00144; DALDHYDRTASE.
DR   SMART; SM01004; ALAD; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00169; D_ALA_DEHYDRATASE; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000515};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU000515}.
FT   ACT_SITE        204
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001415-1"
FT   ACT_SITE        259
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001415-1"
FT   BINDING         244
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001415-5"
SQ   SEQUENCE   335 AA;  36863 MW;  A0AC390959B9D147 CRC64;
     MTYTFNRQFP ETRLRRLRYN DNVRAMIREV ELHPKHFIAP VFVLEGTNQR EAIASMPGVE
     RLSIDLLIDY AKELLAEGVT TIDIFPVVDN SLKTPDGKAA YDEDGLAARA VKAVKDAVPE
     MVVMTDVALD PYTSHGQDGL LDDSGYVVND ATVEVLVKQA LVHARAGADI ISPSDMMDGR
     IRAMRHAFEA EGFANTAIMA YSAKYASAYY GPFRDAVGSA GNLKGGHKKQ YQMDFGNRAE
     ALHEVAMDIN EGADMVMIKP GQPYLDLIRE VKNTFGIPTF AYQVSGEYAM HMAAIQNGWL
     SDAVILESLI GFRRAGADGI LTYFALEAAR QLNNA
//
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